Biological Pathway Reviews
| Mutation Type | Summary | Cancer Type | View |
|---|---|---|---|
| CDK4/6 | The cell-cycle regulatory proteins CDK4 and CDK6 drive progression through the G1–S phase transition, a checkpoint in preventing abnormal cell proliferaition.1,2 Uncontrolled cell division caused by the dysregulated activation of CDK4/6 is common in cancer.Gene deletion, muta |
Breast Cancer; Glioblastoma; Head and Neck Cancer; Liposarcoma; Mantle Cell Lymphoma; Melanoma; Neuroblastoma; NSCLC; Pancreatic Cancer | View |
| CEACAM5 | Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a cell surface glycoprotein that is a member of the carcinoembryonic antigen family, which contains 12 glycoproteins. It is used as a clinical biomarker for many different cancers. |
Breast Cancer; Gastric Cancer; Lung Cancer; Prostate Cancer | View |
| EGFR | The growth-factor-receptor tyrosine kinase family includes EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3), and ErbB4 (HER4).1 Receptor overexpression and ligand-dependent and ligand-independent mechanisms can cause abnormal EGFR activation. |
Anal Cancer; Bladder Cancer; Breast Cancer; Cervical Cancer; Colorectal Cancer; Endometrial Cancer; Esophageal Cancer; Gastric Cancer; Glioblastoma; Head and Neck Cancer; Lung Cancer; Ovarian Cancer; Pancreatic Cancer | View |
| EZH2 | By modulating critical gene expression, EZH2 promotes cell cycle progression, cell proliferation, differentiation, and apoptosis.1 |
Bladder Cancer; Breast Cancer; Colorectal Cancer; Endometrial Cancer; Lung Cancer; Lymphoma; Ovarian Cancer; Prostate Cancer; Renal Cell Carcinoma | View |
| FGFR | Fibroblast growth factor receptors (FGFR) are a gene family of receptor tyrosine kinases that are differentially expressed in a tissue-specific manner throughout development and into adulthood. |
Breast Cancer; Gastric Cancer; Head and Neck Cancer; Melanoma; Multiple Myeloma; Urothelial Cancer | View |
| FLT3 | FLT-3 is a receptor tyrosine kinase that activates pathways leading to the proliferation, differentiation, and apoptosis of hematopoietic cells.1,2 FLT3-ITD mutations and FLT3-TKD mutations can lead to the production of FLT-3 ligands resulting in the activation of FLT-3 and subsequently triggers P |
ALL; AML; Breast Cancer; Cervical Cancer; Colorectal Cancer; Gastric Cancer; Lung Cancer; MDS; Melanoma; Ovarian Cancer; Pancreatic Cancer; Thyroid Cancer | View |
| GPRC5D | G protein-coupled receptor class C group 5 member D (GPRC5D) is a gene expressed in the hair follicle and malignant bone marrow plasma cells.1 G protein-coupled receptor proteins are cell surface receptors located in the plasma membrane. |
Multiple Myeloma | View |
| HER2 | Human epidermal growth factor receptor 2 (HER2) is 1 of 4 transmembrane tyrosine kinase receptor proteins in the epidermal growth factor receptor family.1,2 Normally expressed on epithelial cellular membranes of organs such as breast and skin, HER2 exists in other tissues, includi |
Bladder Cancer; Breast Cancer; Cervical Cancer; Cholangiocarcinoma; Colorectal Cancer; Endometrial Cancer; Esophageal Cancer; Gallbladder Cancer; Gastric Cancer; Head and Neck Cancer; Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Salivary Cancer; Testicular Cancer; Uterine Cancer; Vaginal Cancer | View |
| HRR | Homologous recombination repair (HHR) is a DNA repair mechanism that removes damaged DNA by acting on double-strand breaks, interstrand crosslinks, and other kinds of DNA damage.1 DNA damage is repaired with high fidelity by correcting damage with information copied from a homologous undamaged molecule.2 Defects in HRR are present in some cancers.3 |
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