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Thyroid Cancer Specialty Channel

FDA Approval
FDA Approves Selpercatinib for Adult and Pediatric Patients With Advanced or Metastatic Medullary Thyroid Cancer
09/27/2024
Based on results from the phase 3 LIBRETTO-531 study, the FDA has granted traditional approval to selpercatinib for adult and pediatric patients 2 years and older with advanced or metastatic medullary thyroid cancer harboring a RET mutation.
Based on results from the phase 3 LIBRETTO-531 study, the FDA has granted traditional approval to selpercatinib for adult and pediatric patients 2 years and older with advanced or metastatic medullary thyroid cancer harboring a RET mutation.
Based on results from the phase...
09/27/2024
Oncology
News
FDA Grants Accelerated Approval to Repotrectinib for Adult and Pediatric Patients With NRTK Gene Fusion-Positive Solid Tumors
06/14/2024

Stephanie Holland 

Stephanie Holland 
Based on results from the phase 1/2 TRIDENT-1 study, the US FDA has granted accelerated approval to repotrectinib for adult and pediatric patients 12 years and older with NRTK gene fusion-positive solid tumors.
Based on results from the phase 1/2 TRIDENT-1 study, the US FDA has granted accelerated approval to repotrectinib for adult and pediatric patients 12 years and older with NRTK gene fusion-positive solid tumors.
Based on results from the phase...
06/14/2024
Oncology
FDA Approval
FDA Approves Selpercatinib for Adult and Pediatric Patients With RET Fusion-Positive Thyroid Cancer
06/13/2024

Stephanie Holland 

Stephanie Holland 
Based on results from the LIBRETTO-001 and the LIBRETTO–121 studies, the FDA has approved selpercatinib for adult and pediatric patients with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are...
Based on results from the LIBRETTO-001 and the LIBRETTO–121 studies, the FDA has approved selpercatinib for adult and pediatric patients with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are...
Based on results from the...
06/13/2024
Oncology
News
Selpercatinib Demonstrates Safety, Efficacy in RET-Altered NSCLC and Thyroid Cancer Regardless of Prior Treatment Status
06/28/2022
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic...
06/28/2022
Oncology
Test Your Knowledge
Quiz: Which Treatment Was Recently Granted FDA Approval for DTC?
12/06/2021
Which treatment was recently approved by the FDA for locally advanced or metastatic differentiated thyroid cancer?
Which treatment was recently approved by the FDA for locally advanced or metastatic differentiated thyroid cancer?
Which treatment was recently...
12/06/2021
Oncology
News
Air Pollution May Be Linked to Increased Occurrence of Thyroid Cancer
11/08/2021
A case-control study found that there may be a connection between air pollution exposure and an increased occurrence of thyroid cancer.
A case-control study found that there may be a connection between air pollution exposure and an increased occurrence of thyroid cancer.
A case-control study found that...
11/08/2021
Oncology
News
Pralsetinib Shows Promise in Patients with RET-Altered Thyroid Cancer
10/12/2021
Pralsetinib shows high potency and is well-tolerated in patients with RET-altered thyroid cancer, according to data from phase 1/2 of the ARROW trial.
Pralsetinib shows high potency and is well-tolerated in patients with RET-altered thyroid cancer, according to data from phase 1/2 of the ARROW trial.
Pralsetinib shows high potency...
10/12/2021
Oncology
News
FDA Approves Cabozantinib for Locally Advanced or Metastatic DTC
09/22/2021
The FDA has approved cabozantinib for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) after the results of the COSMIC-311 trial confirm significantly reduced risk...
The FDA has approved cabozantinib for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) after the results of the COSMIC-311 trial confirm significantly reduced risk...
The FDA has approved...
09/22/2021
Oncology
Test Your Knowledge
Quiz: Lenvatinib Monotherapy for Patients with Anaplastic Thyroid Cancer
09/01/2021
True or false: Results from a phase 2 trial suggest lenvatinib monotherapy may be an effective treatment for anaplastic thyroid cancer.
True or false: Results from a phase 2 trial suggest lenvatinib monotherapy may be an effective treatment for anaplastic thyroid cancer.
True or false: Results from a...
09/01/2021
Oncology
News
Lenvatinib Not Effective for Patients With Anaplastic Thyroid Cancer
08/03/2021
Lenvatinib monotherapy showed manageable safety but low activity in patients with anaplastic thyroid cancer.
Lenvatinib monotherapy showed manageable safety but low activity in patients with anaplastic thyroid cancer.
Lenvatinib monotherapy showed...
08/03/2021
Oncology
News
Cabozantinib Improves PFS in Patients with RAI-Refractory DTC
07/06/2021
Patients with RAI-refractory differentiated thyroid cancer who progressed after previous VEGFR-targeted therapy saw improved survival when treated with cabozantinib.
Patients with RAI-refractory differentiated thyroid cancer who progressed after previous VEGFR-targeted therapy saw improved survival when treated with cabozantinib.
Patients with RAI-refractory...
07/06/2021
Oncology

News

FDA Approval
FDA Approves Selpercatinib for Adult and Pediatric Patients With Advanced or Metastatic Medullary Thyroid Cancer
09/27/2024
Based on results from the phase 3 LIBRETTO-531 study, the FDA has granted traditional approval to selpercatinib for adult and pediatric patients 2 years and older with advanced or metastatic medullary thyroid cancer harboring a RET mutation.
Based on results from the phase 3 LIBRETTO-531 study, the FDA has granted traditional approval to selpercatinib for adult and pediatric patients 2 years and older with advanced or metastatic medullary thyroid cancer harboring a RET mutation.
Based on results from the phase...
09/27/2024
Oncology
News
FDA Grants Accelerated Approval to Repotrectinib for Adult and Pediatric Patients With NRTK Gene Fusion-Positive Solid Tumors
06/14/2024

Stephanie Holland 

Stephanie Holland 
Based on results from the phase 1/2 TRIDENT-1 study, the US FDA has granted accelerated approval to repotrectinib for adult and pediatric patients 12 years and older with NRTK gene fusion-positive solid tumors.
Based on results from the phase 1/2 TRIDENT-1 study, the US FDA has granted accelerated approval to repotrectinib for adult and pediatric patients 12 years and older with NRTK gene fusion-positive solid tumors.
Based on results from the phase...
06/14/2024
Oncology
FDA Approval
FDA Approves Selpercatinib for Adult and Pediatric Patients With RET Fusion-Positive Thyroid Cancer
06/13/2024

Stephanie Holland 

Stephanie Holland 
Based on results from the LIBRETTO-001 and the LIBRETTO–121 studies, the FDA has approved selpercatinib for adult and pediatric patients with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are...
Based on results from the LIBRETTO-001 and the LIBRETTO–121 studies, the FDA has approved selpercatinib for adult and pediatric patients with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are...
Based on results from the...
06/13/2024
Oncology
News
Selpercatinib Demonstrates Safety, Efficacy in RET-Altered NSCLC and Thyroid Cancer Regardless of Prior Treatment Status
06/28/2022
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic...
06/28/2022
Oncology
News
Air Pollution May Be Linked to Increased Occurrence of Thyroid Cancer
11/08/2021
A case-control study found that there may be a connection between air pollution exposure and an increased occurrence of thyroid cancer.
A case-control study found that there may be a connection between air pollution exposure and an increased occurrence of thyroid cancer.
A case-control study found that...
11/08/2021
Oncology
News
Pralsetinib Shows Promise in Patients with RET-Altered Thyroid Cancer
10/12/2021
Pralsetinib shows high potency and is well-tolerated in patients with RET-altered thyroid cancer, according to data from phase 1/2 of the ARROW trial.
Pralsetinib shows high potency and is well-tolerated in patients with RET-altered thyroid cancer, according to data from phase 1/2 of the ARROW trial.
Pralsetinib shows high potency...
10/12/2021
Oncology
News
FDA Approves Cabozantinib for Locally Advanced or Metastatic DTC
09/22/2021
The FDA has approved cabozantinib for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) after the results of the COSMIC-311 trial confirm significantly reduced risk...
The FDA has approved cabozantinib for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) after the results of the COSMIC-311 trial confirm significantly reduced risk...
The FDA has approved...
09/22/2021
Oncology
News
Lenvatinib Not Effective for Patients With Anaplastic Thyroid Cancer
08/03/2021
Lenvatinib monotherapy showed manageable safety but low activity in patients with anaplastic thyroid cancer.
Lenvatinib monotherapy showed manageable safety but low activity in patients with anaplastic thyroid cancer.
Lenvatinib monotherapy showed...
08/03/2021
Oncology
News
Cabozantinib Improves PFS in Patients with RAI-Refractory DTC
07/06/2021
Patients with RAI-refractory differentiated thyroid cancer who progressed after previous VEGFR-targeted therapy saw improved survival when treated with cabozantinib.
Patients with RAI-refractory differentiated thyroid cancer who progressed after previous VEGFR-targeted therapy saw improved survival when treated with cabozantinib.
Patients with RAI-refractory...
07/06/2021
Oncology
News
Pesticide Exposure Linked to Increased Risk for Thyroid Cancer
05/10/2021
Results from a cohort study on male pesticide applicators found that extended use of pesticides were tied to an increased risk for thyroid cancer.
Results from a cohort study on male pesticide applicators found that extended use of pesticides were tied to an increased risk for thyroid cancer.
Results from a cohort study on...
05/10/2021
Oncology

Interactive Features

Test Your Knowledge
Quiz: Which Treatment Was Recently Granted FDA Approval for DTC?
12/06/2021
Which treatment was recently approved by the FDA for locally advanced or metastatic differentiated thyroid cancer?
Which treatment was recently approved by the FDA for locally advanced or metastatic differentiated thyroid cancer?
Which treatment was recently...
12/06/2021
Oncology
Test Your Knowledge
Quiz: Lenvatinib Monotherapy for Patients with Anaplastic Thyroid Cancer
09/01/2021
True or false: Results from a phase 2 trial suggest lenvatinib monotherapy may be an effective treatment for anaplastic thyroid cancer.
True or false: Results from a phase 2 trial suggest lenvatinib monotherapy may be an effective treatment for anaplastic thyroid cancer.
True or false: Results from a...
09/01/2021
Oncology
Quiz
Quiz: Efficacy of Vandetanib, Cabozantinib for Advanced MTCctive in Treating Advanced MTC?
06/21/2021
True or False: Results from a real-world study showed that vandetanib and cabozantinib were ineffective for the treatment of patients with advanced MTC.
True or False: Results from a real-world study showed that vandetanib and cabozantinib were ineffective for the treatment of patients with advanced MTC.
True or False: Results from a...
06/21/2021
Oncology
Test Your Knowledge
Quiz: Does Artificial LAN Increase the Risk of Thyroid Cancer?
04/05/2021
True or false: Artificial LAN may increase the risk of thyroid cancer?
True or false: Artificial LAN may increase the risk of thyroid cancer?
True or false: Artificial LAN...
04/05/2021
Oncology
Test Your Knowledge
Quiz: Has Selpercatinib Been Proven Effective in Thyroid Cancer?
02/01/2021
True or false: A phase 1/2 trial found Selpercatinib to be ineffective in patients with RET-mutant medullary thyroid cancer.
True or false: A phase 1/2 trial found Selpercatinib to be ineffective in patients with RET-mutant medullary thyroid cancer.
True or false: A phase 1/2 trial...
02/01/2021
Oncology
Test Your Knowledge
Quiz: Which Treatment Was Recently Granted Accelerated Approval in RET-Altered Thyroid Cancers?
01/11/2021
Which of the following applications were recently granted accelerated approval by the FDA for adult and pediatric advanced or metastatic RET-altered thyroid cancer requiring systemic therapy?
Which of the following applications were recently granted accelerated approval by the FDA for adult and pediatric advanced or metastatic RET-altered thyroid cancer requiring systemic therapy?
Which of the following...
01/11/2021
Oncology
Test Your Knowledge
Quiz: The FDA Approved Pralsetinib For Which Type of Thyroid Cancer?
01/08/2021
The FDA recently approved pralsetinib for RET-altered _______ thyroid cancer.
The FDA recently approved pralsetinib for RET-altered _______ thyroid cancer.
The FDA recently approved...
01/08/2021
Oncology

Recent News

FDA Approval
FDA Approves Selpercatinib for Adult and Pediatric Patients With Advanced or Metastatic Medullary Thyroid Cancer
09/27/2024
Based on results from the phase 3 LIBRETTO-531 study, the FDA has granted traditional approval to selpercatinib for adult and pediatric patients 2 years and older with advanced or metastatic medullary thyroid cancer harboring a RET mutation.
Based on results from the phase 3 LIBRETTO-531 study, the FDA has granted traditional approval to selpercatinib for adult and pediatric patients 2 years and older with advanced or metastatic medullary thyroid cancer harboring a RET mutation.
Based on results from the phase...
09/27/2024
Oncology
News
FDA Grants Accelerated Approval to Repotrectinib for Adult and Pediatric Patients With NRTK Gene Fusion-Positive Solid Tumors
06/14/2024

Stephanie Holland 

Stephanie Holland 
Based on results from the phase 1/2 TRIDENT-1 study, the US FDA has granted accelerated approval to repotrectinib for adult and pediatric patients 12 years and older with NRTK gene fusion-positive solid tumors.
Based on results from the phase 1/2 TRIDENT-1 study, the US FDA has granted accelerated approval to repotrectinib for adult and pediatric patients 12 years and older with NRTK gene fusion-positive solid tumors.
Based on results from the phase...
06/14/2024
Oncology
FDA Approval
FDA Approves Selpercatinib for Adult and Pediatric Patients With RET Fusion-Positive Thyroid Cancer
06/13/2024

Stephanie Holland 

Stephanie Holland 
Based on results from the LIBRETTO-001 and the LIBRETTO–121 studies, the FDA has approved selpercatinib for adult and pediatric patients with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are...
Based on results from the LIBRETTO-001 and the LIBRETTO–121 studies, the FDA has approved selpercatinib for adult and pediatric patients with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are...
Based on results from the...
06/13/2024
Oncology
News
Selpercatinib Demonstrates Safety, Efficacy in RET-Altered NSCLC and Thyroid Cancer Regardless of Prior Treatment Status
06/28/2022
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic review and meta-analysis show that selpercatinib is a safe and effective option for patients with RET-altered NSCLC and thyroid cancer, regardless of previous therapies or RET alteration type.
Findings from a systematic...
06/28/2022
Oncology
News
Air Pollution May Be Linked to Increased Occurrence of Thyroid Cancer
11/08/2021
A case-control study found that there may be a connection between air pollution exposure and an increased occurrence of thyroid cancer.
A case-control study found that there may be a connection between air pollution exposure and an increased occurrence of thyroid cancer.
A case-control study found that...
11/08/2021
Oncology
News
Pralsetinib Shows Promise in Patients with RET-Altered Thyroid Cancer
10/12/2021
Pralsetinib shows high potency and is well-tolerated in patients with RET-altered thyroid cancer, according to data from phase 1/2 of the ARROW trial.
Pralsetinib shows high potency and is well-tolerated in patients with RET-altered thyroid cancer, according to data from phase 1/2 of the ARROW trial.
Pralsetinib shows high potency...
10/12/2021
Oncology
News
FDA Approves Cabozantinib for Locally Advanced or Metastatic DTC
09/22/2021
The FDA has approved cabozantinib for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) after the results of the COSMIC-311 trial confirm significantly reduced risk...
The FDA has approved cabozantinib for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) after the results of the COSMIC-311 trial confirm significantly reduced risk...
The FDA has approved...
09/22/2021
Oncology
News
Lenvatinib Not Effective for Patients With Anaplastic Thyroid Cancer
08/03/2021
Lenvatinib monotherapy showed manageable safety but low activity in patients with anaplastic thyroid cancer.
Lenvatinib monotherapy showed manageable safety but low activity in patients with anaplastic thyroid cancer.
Lenvatinib monotherapy showed...
08/03/2021
Oncology
News
Cabozantinib Improves PFS in Patients with RAI-Refractory DTC
07/06/2021
Patients with RAI-refractory differentiated thyroid cancer who progressed after previous VEGFR-targeted therapy saw improved survival when treated with cabozantinib.
Patients with RAI-refractory differentiated thyroid cancer who progressed after previous VEGFR-targeted therapy saw improved survival when treated with cabozantinib.
Patients with RAI-refractory...
07/06/2021
Oncology
News
Pesticide Exposure Linked to Increased Risk for Thyroid Cancer
05/10/2021
Results from a cohort study on male pesticide applicators found that extended use of pesticides were tied to an increased risk for thyroid cancer.
Results from a cohort study on male pesticide applicators found that extended use of pesticides were tied to an increased risk for thyroid cancer.
Results from a cohort study on...
05/10/2021
Oncology
News
Intraoperative Radiation Therapy May Improve Survival For Certain Patients With Recurrent Cervical or Endometrial Cancer
11/14/2024
According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.
According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.
According to a retrospective...
11/14/2024
Oncology
News
Amrubicin Plus Irinotecan Demonstrates Promising Efficacy, Safety for Chemotherapy-Naïve Patients With Extensive-Disease Small Cell Lung Cancer
11/14/2024
According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.
According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.
According to results from the...
11/14/2024
Oncology
News
Addition of Bempegaldesleukin to Nivolumab Does Not Benefit Cisplatin-Ineligible Patients With First-Line Advanced Urothelial Carcinoma
11/13/2024
Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.
Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.
Results from the phase 2...
11/13/2024
Oncology
News
Mirdametinib for Adult and Pediatric Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas
11/12/2024
According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...
According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...
According to a phase 2b trial,...
11/12/2024
Oncology
News
Epirubicin Plus Cyclophosphamide and Docetaxel Reduces Long-Term Risk of Recurrence for Patients With TOP2A Normal Early Breast Cancer
11/12/2024
According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.
According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.
According to final results from...
11/12/2024
Oncology
News
Pembrolizumab Plus Chemotherapy For Patients With High-Risk Endometrial Cancer
11/11/2024
According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.
According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.
According to results from a...
11/11/2024
Oncology
FDA Approval
FDA Grants Approval to Obecabtagene Autoleucel for R/R B-Cell Precursor Acute Lymphoblastic Leukemia
11/08/2024
On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
On November 8, 2024, the FDA...
11/08/2024
Oncology
News
Naporafenib in Combination With Rineterkib or Tremetinib for KRAS- or BRAF-Mutant Non-Small Cell Lung Cancer
11/07/2024
While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.
While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.
While naporafenib plus...
11/07/2024
Oncology
News
Addition of Concurrent Thoracic Radiotherapy to First-Line TKI Therapy Improves Survival for Patients With EGFR-Mutated Non-Small Cell Lung Cancer
11/06/2024
According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.
According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.
According to results from a...
11/06/2024
Oncology
News
Ipilimumab After PD-1 Inhibition Failure Among Patients With Metastatic Melanoma
11/05/2024
A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.
A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.
A single-center real-world study...
11/05/2024
Oncology

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