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Chronic Myeloid Leukemia Specialty Channel

Chronic Myeloid Leukemia
Specialty Channel
FDA Approval
10/29/2024
The FDA granted accelerated approval to asciminib for patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase.
The FDA granted accelerated approval to asciminib for patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase.
The FDA granted accelerated...
10/29/2024
Oncology
News
03/22/2024

Amber Denham

Amber Denham
According to a real-world, retrospective study, nilotinib, dasatinib, or flumatinib therapy each showed comparable efficacy, higher therapy responses and higher failure-free survival rates than imatinib among newly diagnosed patients with...
According to a real-world, retrospective study, nilotinib, dasatinib, or flumatinib therapy each showed comparable efficacy, higher therapy responses and higher failure-free survival rates than imatinib among newly diagnosed patients with...
According to a real-world,...
03/22/2024
Oncology
News
06/23/2023
Results from the ASCEMBL trial indicated that asciminib, a BCR::ABL1 inhibitor, demonstrated superior efficacy and safety compared to bosutinib among patients with Philadelphia chromosome-positive chronic myeloid leukemia.
Results from the ASCEMBL trial indicated that asciminib, a BCR::ABL1 inhibitor, demonstrated superior efficacy and safety compared to bosutinib among patients with Philadelphia chromosome-positive chronic myeloid leukemia.
Results from the ASCEMBL trial...
06/23/2023
Oncology
News
10/17/2022
Olverembatinib, a novel tyrosine kinase inhibitor (TKI), was well tolerated and demonstrated significant anti-leukemic activity in adults with TKI-resistant CML-CP and CML-AP, especially those with the T315I mutation, according to results...
Olverembatinib, a novel tyrosine kinase inhibitor (TKI), was well tolerated and demonstrated significant anti-leukemic activity in adults with TKI-resistant CML-CP and CML-AP, especially those with the T315I mutation, according to results...
Olverembatinib, a novel tyrosine...
10/17/2022
Oncology
News
11/01/2021
The FDA granted accelerated approval to asciminib for the use in the treatment of patients with Ph+ CML in CP with or without the T315I mutation who were previously treated with 2 or more TKIs.
The FDA granted accelerated approval to asciminib for the use in the treatment of patients with Ph+ CML in CP with or without the T315I mutation who were previously treated with 2 or more TKIs.
The FDA granted accelerated...
11/01/2021
Oncology
Test Your Knowledge
09/10/2021
Which of the following is not a current standard of care option for the treatment of patients with CML?
Which of the following is not a current standard of care option for the treatment of patients with CML?
Which of the following is not a...
09/10/2021
Oncology
Test Your Knowledge
04/20/2021
Study findings reported by researchers in Algeria suggest that b3a2 transcript may be tied to ____ (better/worse) responses to imatinib therapy in patients with chronic myeloid leukemia.
Study findings reported by researchers in Algeria suggest that b3a2 transcript may be tied to ____ (better/worse) responses to imatinib therapy in patients with chronic myeloid leukemia.
Study findings reported by...
04/20/2021
Oncology
Test Your Knowledge
03/16/2021
According to experts, which of the following therapy options is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase?
According to experts, which of the following therapy options is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase?
According to experts, which of...
03/16/2021
Oncology
Test Your Knowledge
02/17/2021
Prior to experts utilizing tyrosine kinase inhibitors as treatment for chronic myeloid leukemia, a stem cell transplant was required.
Prior to experts utilizing tyrosine kinase inhibitors as treatment for chronic myeloid leukemia, a stem cell transplant was required.
Prior to experts utilizing...
02/17/2021
Oncology
Test Your Knowledge
12/23/2020
True of False: The ASCEMBL data concludes that, with ABL-specific inhibition, asciminib has a reduced rate of side effects that lead to discontinuation or dose adjustment compared to the TKI drug bosutinib, while improving the response rate...
True of False: The ASCEMBL data concludes that, with ABL-specific inhibition, asciminib has a reduced rate of side effects that lead to discontinuation or dose adjustment compared to the TKI drug bosutinib, while improving the response rate...
True of False: The ASCEMBL data...
12/23/2020
Oncology
Test Your Knowledge
11/25/2020
True or False: Imatinib is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase.
True or False: Imatinib is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase.
True or False: Imatinib is...
11/25/2020
Oncology

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News

News
03/22/2024

Amber Denham

Amber Denham
According to a real-world, retrospective study, nilotinib, dasatinib, or flumatinib therapy each showed comparable efficacy, higher therapy responses and higher failure-free survival rates than imatinib among newly diagnosed patients with...
According to a real-world, retrospective study, nilotinib, dasatinib, or flumatinib therapy each showed comparable efficacy, higher therapy responses and higher failure-free survival rates than imatinib among newly diagnosed patients with...
According to a real-world,...
03/22/2024
Oncology
News
06/23/2023
Results from the ASCEMBL trial indicated that asciminib, a BCR::ABL1 inhibitor, demonstrated superior efficacy and safety compared to bosutinib among patients with Philadelphia chromosome-positive chronic myeloid leukemia.
Results from the ASCEMBL trial indicated that asciminib, a BCR::ABL1 inhibitor, demonstrated superior efficacy and safety compared to bosutinib among patients with Philadelphia chromosome-positive chronic myeloid leukemia.
Results from the ASCEMBL trial...
06/23/2023
Oncology
News
10/17/2022
Olverembatinib, a novel tyrosine kinase inhibitor (TKI), was well tolerated and demonstrated significant anti-leukemic activity in adults with TKI-resistant CML-CP and CML-AP, especially those with the T315I mutation, according to results...
Olverembatinib, a novel tyrosine kinase inhibitor (TKI), was well tolerated and demonstrated significant anti-leukemic activity in adults with TKI-resistant CML-CP and CML-AP, especially those with the T315I mutation, according to results...
Olverembatinib, a novel tyrosine...
10/17/2022
Oncology
News
11/01/2021
The FDA granted accelerated approval to asciminib for the use in the treatment of patients with Ph+ CML in CP with or without the T315I mutation who were previously treated with 2 or more TKIs.
The FDA granted accelerated approval to asciminib for the use in the treatment of patients with Ph+ CML in CP with or without the T315I mutation who were previously treated with 2 or more TKIs.
The FDA granted accelerated...
11/01/2021
Oncology
News
10/08/2020
Results from a prospective study in India show that the generic version of imatinib yields similar efficacy and safety, with lower cost, in patients with CML-CP.
Results from a prospective study in India show that the generic version of imatinib yields similar efficacy and safety, with lower cost, in patients with CML-CP.
Results from a prospective study...
10/08/2020
Oncology
News
09/29/2020
Study findings suggest that b3a2 transcript may be tied to better responses to imatinib therapy in patients with CML.
Study findings suggest that b3a2 transcript may be tied to better responses to imatinib therapy in patients with CML.
Study findings suggest that b3a2...
09/29/2020
Oncology
News
07/18/2020
At the virtual Great Debates & Updates in Hematologic Malignancies, Michael Mauro, MD, presented on practical approaches for monitoring patients with CML as per NCCN and ELN recommendations.
At the virtual Great Debates & Updates in Hematologic Malignancies, Michael Mauro, MD, presented on practical approaches for monitoring patients with CML as per NCCN and ELN recommendations.
At the virtual Great Debates &...
07/18/2020
Oncology
News
06/15/2020
Retrospective study findings demonstrated that, in patients with CML, administration of low-dose TKIs before TKI cessation does not impair treatment‐free remission.
Retrospective study findings demonstrated that, in patients with CML, administration of low-dose TKIs before TKI cessation does not impair treatment‐free remission.
Retrospective study findings...
06/15/2020
Oncology
News
05/14/2020
Study findings support using NGS to illustrate BCR-ABL1 mutation status in patients with CML who do not respond or have warning responses to TKI therapy.
Study findings support using NGS to illustrate BCR-ABL1 mutation status in patients with CML who do not respond or have warning responses to TKI therapy.
Study findings support using NGS...
05/14/2020
Oncology
News
05/07/2020
Study findings suggest that switching patients with CML-CP from first-line imatinib to dasatinib may at times be beneficial.
Study findings suggest that switching patients with CML-CP from first-line imatinib to dasatinib may at times be beneficial.
Study findings suggest that...
05/07/2020
Oncology

Interactive Features

Test Your Knowledge
09/10/2021
Which of the following is not a current standard of care option for the treatment of patients with CML?
Which of the following is not a current standard of care option for the treatment of patients with CML?
Which of the following is not a...
09/10/2021
Oncology
Test Your Knowledge
04/20/2021
Study findings reported by researchers in Algeria suggest that b3a2 transcript may be tied to ____ (better/worse) responses to imatinib therapy in patients with chronic myeloid leukemia.
Study findings reported by researchers in Algeria suggest that b3a2 transcript may be tied to ____ (better/worse) responses to imatinib therapy in patients with chronic myeloid leukemia.
Study findings reported by...
04/20/2021
Oncology
Test Your Knowledge
03/16/2021
According to experts, which of the following therapy options is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase?
According to experts, which of the following therapy options is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase?
According to experts, which of...
03/16/2021
Oncology
Test Your Knowledge
02/17/2021
Prior to experts utilizing tyrosine kinase inhibitors as treatment for chronic myeloid leukemia, a stem cell transplant was required.
Prior to experts utilizing tyrosine kinase inhibitors as treatment for chronic myeloid leukemia, a stem cell transplant was required.
Prior to experts utilizing...
02/17/2021
Oncology
Test Your Knowledge
12/23/2020
True of False: The ASCEMBL data concludes that, with ABL-specific inhibition, asciminib has a reduced rate of side effects that lead to discontinuation or dose adjustment compared to the TKI drug bosutinib, while improving the response rate...
True of False: The ASCEMBL data concludes that, with ABL-specific inhibition, asciminib has a reduced rate of side effects that lead to discontinuation or dose adjustment compared to the TKI drug bosutinib, while improving the response rate...
True of False: The ASCEMBL data...
12/23/2020
Oncology
Test Your Knowledge
11/25/2020
True or False: Imatinib is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase.
True or False: Imatinib is considered the gold standard for frontline treatment of newly diagnosed chronic myeloid leukemia in chronic-phase.
True or False: Imatinib is...
11/25/2020
Oncology
Test Your Knowledge
10/28/2020
True or False: Although FISH testing has been applied to provide definitive information in chronic myeloid leukemia, additional information provided by FISH testing, such as atypical signal patterns that indicate for complicated chromosomal...
True or False: Although FISH testing has been applied to provide definitive information in chronic myeloid leukemia, additional information provided by FISH testing, such as atypical signal patterns that indicate for complicated chromosomal...
True or False: Although FISH...
10/28/2020
Oncology
Test Your Knowledge
09/25/2020
Which clinical trial displayed results that were in favor of imatinib, both in terms of efficacy and tolerability, for chronic myeloid leukemia?
Which clinical trial displayed results that were in favor of imatinib, both in terms of efficacy and tolerability, for chronic myeloid leukemia?
Which clinical trial displayed...
09/25/2020
Oncology
Test Your Knowledge
08/19/2020
True or False: The administration of low-dose TKIs before TKI cessation impairs treatment‐free remission in patients with CML.
True or False: The administration of low-dose TKIs before TKI cessation impairs treatment‐free remission in patients with CML.
True or False: The...
08/19/2020
Oncology
Test Your Knowledge
07/28/2020
True or False: Switching from imatinib to dasatinib, in cases of suboptimal response, may offer clinical benefit in patients with CML.
True or False: Switching from imatinib to dasatinib, in cases of suboptimal response, may offer clinical benefit in patients with CML.
True or False: Switching from...
07/28/2020
Oncology

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