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Sarcoma Specialty Channel

FDA Approval
08/02/2024
On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...
On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...
On August 2, 2024, the US Food...
08/02/2024
Oncology
News
06/02/2022

John Otrompke

John Otrompke
Second-line or later treatment with selinexor for metastatic, advanced dedifferentiated liposarcoma was associated with longer PFS and time to next treatment compared to placebo.
Second-line or later treatment with selinexor for metastatic, advanced dedifferentiated liposarcoma was associated with longer PFS and time to next treatment compared to placebo.
Second-line or later treatment...
06/02/2022
Oncology
Test Your Knowledge
09/14/2021
True or false: In the treatment of advanced STS, randomized trials with QoL assessment were more likely to achieve the ESMO-Magnitude of Clinical Benefit Scale substantial benefit threshold.
True or false: In the treatment of advanced STS, randomized trials with QoL assessment were more likely to achieve the ESMO-Magnitude of Clinical Benefit Scale substantial benefit threshold.
True or false: In the treatment...
09/14/2021
Oncology
Conference Coverage
09/14/2021
The ESMO-MCBS medical device was evaluated for its ability to assess the magnitude of clinical benefit, quality of life, and outcomes in advanced STS and GIST in; these data were presented at the virtual 2021 ESMO Congress.
The ESMO-MCBS medical device was evaluated for its ability to assess the magnitude of clinical benefit, quality of life, and outcomes in advanced STS and GIST in; these data were presented at the virtual 2021 ESMO Congress.
The ESMO-MCBS medical device was...
09/14/2021
Oncology
Test Your Knowledge
11/09/2020
True or false: The FDA recently approved the first new AIDS-related Kaposi sarcoma treatment in 6 years.
True or false: The FDA recently approved the first new AIDS-related Kaposi sarcoma treatment in 6 years.
True or false: The FDA recently...
11/09/2020
Oncology
News
10/26/2020
The FDA has approved the NGS companion diagnostic FoundationOne CDx test to identify NTRK gene fusions in solid tumor tissue from patients eligible for treatment with larotrectinib.
The FDA has approved the NGS companion diagnostic FoundationOne CDx test to identify NTRK gene fusions in solid tumor tissue from patients eligible for treatment with larotrectinib.
The FDA has approved the NGS...
10/26/2020
Oncology
Podcasts
10/15/2020
In the fourth episode, Brian Van Tine, MD, PhD, and Robert “Bob” Maki, MD, PhD, discuss recent trial data and evolving therapies for treatment of Ewing sarcoma.
In the fourth episode, Brian Van Tine, MD, PhD, and Robert “Bob” Maki, MD, PhD, discuss recent trial data and evolving therapies for treatment of Ewing sarcoma.
In the fourth episode, Brian Van...
10/15/2020
Oncology
Episode 3: Standard of Care Treatment for Ewing Sarcoma
Podcasts
09/24/2020
Brian Van Tine, MD, PhD, and Robert “Bob” Maki, MD, PhD, discuss recent data comparing the American Standard versus European Standard for treatment of Ewing sarcoma.
Brian Van Tine, MD, PhD, and Robert “Bob” Maki, MD, PhD, discuss recent data comparing the American Standard versus European Standard for treatment of Ewing sarcoma.
Brian Van Tine, MD, PhD, and...
09/24/2020
Oncology
News
09/23/2020
Doxorubicin combined with pembrolizumab has shown promise in the treatment of patients with advanced anthracycline-naïve sarcoma, according to phase 1/2 study findings.
Doxorubicin combined with pembrolizumab has shown promise in the treatment of patients with advanced anthracycline-naïve sarcoma, according to phase 1/2 study findings.
Doxorubicin combined with...
09/23/2020
Oncology
Test Your Knowledge
08/13/2020
In a large clinical study, which of the following agents yielded durable responses in patients with epithelioid sarcoma?
In a large clinical study, which of the following agents yielded durable responses in patients with epithelioid sarcoma?
In a large clinical study, which...
08/13/2020
Oncology
Test Your Knowledge
08/11/2020
True or False: Radiotherapy is no longer a primary therapy option in most tertiary tumor centers, while surgical resection, either open or arthroscopic, is.
True or False: Radiotherapy is no longer a primary therapy option in most tertiary tumor centers, while surgical resection, either open or arthroscopic, is.
True or False: Radiotherapy is...
08/11/2020
Oncology

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News

FDA Approval
08/02/2024
On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...
On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...
On August 2, 2024, the US Food...
08/02/2024
Oncology
News
06/02/2022

John Otrompke

John Otrompke
Second-line or later treatment with selinexor for metastatic, advanced dedifferentiated liposarcoma was associated with longer PFS and time to next treatment compared to placebo.
Second-line or later treatment with selinexor for metastatic, advanced dedifferentiated liposarcoma was associated with longer PFS and time to next treatment compared to placebo.
Second-line or later treatment...
06/02/2022
Oncology
Conference Coverage
09/14/2021
The ESMO-MCBS medical device was evaluated for its ability to assess the magnitude of clinical benefit, quality of life, and outcomes in advanced STS and GIST in; these data were presented at the virtual 2021 ESMO Congress.
The ESMO-MCBS medical device was evaluated for its ability to assess the magnitude of clinical benefit, quality of life, and outcomes in advanced STS and GIST in; these data were presented at the virtual 2021 ESMO Congress.
The ESMO-MCBS medical device was...
09/14/2021
Oncology
News
10/26/2020
The FDA has approved the NGS companion diagnostic FoundationOne CDx test to identify NTRK gene fusions in solid tumor tissue from patients eligible for treatment with larotrectinib.
The FDA has approved the NGS companion diagnostic FoundationOne CDx test to identify NTRK gene fusions in solid tumor tissue from patients eligible for treatment with larotrectinib.
The FDA has approved the NGS...
10/26/2020
Oncology
News
09/23/2020
Doxorubicin combined with pembrolizumab has shown promise in the treatment of patients with advanced anthracycline-naïve sarcoma, according to phase 1/2 study findings.
Doxorubicin combined with pembrolizumab has shown promise in the treatment of patients with advanced anthracycline-naïve sarcoma, according to phase 1/2 study findings.
Doxorubicin combined with...
09/23/2020
Oncology
News
05/31/2020
A maintenance therapy regimen comprising oral cyclophosphamide plus celecoxib has demonstrated feasibility in patients with metastatic Ewing sarcoma.
A maintenance therapy regimen comprising oral cyclophosphamide plus celecoxib has demonstrated feasibility in patients with metastatic Ewing sarcoma.
A maintenance therapy regimen...
05/31/2020
Oncology
News
05/15/2020
The FDA has approved pomalidomide for use in adults with AIDS-related Kaposi sarcoma unresponsive to antiretroviral therapy and Kaposi sarcoma in HIV-negative adults.
The FDA has approved pomalidomide for use in adults with AIDS-related Kaposi sarcoma unresponsive to antiretroviral therapy and Kaposi sarcoma in HIV-negative adults.
The FDA has approved...
05/15/2020
Oncology
News
05/06/2020
Germline genetic testing may be warranted for patients with osteosarcoma, according to findings from a study by Lisa Mirabello, PhD, et al.
Germline genetic testing may be warranted for patients with osteosarcoma, according to findings from a study by Lisa Mirabello, PhD, et al.
Germline genetic testing may be...
05/06/2020
Oncology
News
04/29/2020
Adding olaratumab to doxorubicin in patients with advanced STS did not significantly improve OS in the ANNOUNCE clinical trial.
Adding olaratumab to doxorubicin in patients with advanced STS did not significantly improve OS in the ANNOUNCE clinical trial.
Adding olaratumab to doxorubicin...
04/29/2020
Oncology
News
04/13/2020
In a study of patients with chondrosarcoma, ivosidenib therapy yielded limited toxicity and durable disease control.
In a study of patients with chondrosarcoma, ivosidenib therapy yielded limited toxicity and durable disease control.
In a study of patients with...
04/13/2020
Oncology

Interactive Features

Test Your Knowledge
09/14/2021
True or false: In the treatment of advanced STS, randomized trials with QoL assessment were more likely to achieve the ESMO-Magnitude of Clinical Benefit Scale substantial benefit threshold.
True or false: In the treatment of advanced STS, randomized trials with QoL assessment were more likely to achieve the ESMO-Magnitude of Clinical Benefit Scale substantial benefit threshold.
True or false: In the treatment...
09/14/2021
Oncology
Test Your Knowledge
11/09/2020
True or false: The FDA recently approved the first new AIDS-related Kaposi sarcoma treatment in 6 years.
True or false: The FDA recently approved the first new AIDS-related Kaposi sarcoma treatment in 6 years.
True or false: The FDA recently...
11/09/2020
Oncology
Test Your Knowledge
08/13/2020
In a large clinical study, which of the following agents yielded durable responses in patients with epithelioid sarcoma?
In a large clinical study, which of the following agents yielded durable responses in patients with epithelioid sarcoma?
In a large clinical study, which...
08/13/2020
Oncology
Test Your Knowledge
08/11/2020
True or False: Radiotherapy is no longer a primary therapy option in most tertiary tumor centers, while surgical resection, either open or arthroscopic, is.
True or False: Radiotherapy is no longer a primary therapy option in most tertiary tumor centers, while surgical resection, either open or arthroscopic, is.
True or False: Radiotherapy is...
08/11/2020
Oncology
Test Your Knowledge
07/20/2020
True or False: Cabozantinib has shown anti-tumor activity in patients with advanced Ewing sarcoma and osteosarcoma.
True or False: Cabozantinib has shown anti-tumor activity in patients with advanced Ewing sarcoma and osteosarcoma.
True or False: Cabozantinib has...
07/20/2020
Oncology
Test Your Knowledge
01/10/2020
What are the 2 types of tenosynovial giant cell tumors?
What are the 2 types of tenosynovial giant cell tumors?
What are the 2 types of...
01/10/2020
Oncology
Test Your Knowledge
01/06/2020
True or False: Almost any joint in the body can be affected by tenosynovial giant cell tumors.
True or False: Almost any joint in the body can be affected by tenosynovial giant cell tumors.
True or False: Almost any joint...
01/06/2020
Oncology
Test Your Knowledge
12/18/2019
Findings from a phase 1 trial show that DCC-3014 is ______ in patients with diffuse-type TGCT.
Findings from a phase 1 trial show that DCC-3014 is ______ in patients with diffuse-type TGCT.
Findings from a phase 1 trial...
12/18/2019
Oncology
Test Your Knowledge
12/18/2019
True or False: Historically, TGCT has been managed by multiple surgical resections, including joint replacement therapy and (even in rare cases) amputation.
True or False: Historically, TGCT has been managed by multiple surgical resections, including joint replacement therapy and (even in rare cases) amputation.
True or False: Historically,...
12/18/2019
Oncology
Test Your Knowledge
10/01/2019
True or False: Pazopanib may be a suitable therapy option for patients with progressive and advanced extraskeletal myxoid chondrosarcoma who do not respond to first-line anthracycline-based chemo.
True or False: Pazopanib may be a suitable therapy option for patients with progressive and advanced extraskeletal myxoid chondrosarcoma who do not respond to first-line anthracycline-based chemo.
True or False: Pazopanib may be...
10/01/2019
Oncology

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