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Gastroesophageal Junction Cancer Specialty Channel

Gastroesophageal Junction Cancer
Specialty Channel
FDA Approval
FDA Approves Zolbetuximab Plus Chemotherapy for Patients With HER2-Negative Gastric/Gastroesophageal Junction Adenocarcinoma With CLDN18.2-Positive Tumors
10/18/2024
Based on results from the SPOTLIGHT and GLOW trials, the FDA has approved first-line zolbetuximab plus fluoropyrimidine and platinum-containing chemotherapy for patients with locally advanced, unresectable, or metastatic HER2-negative gastric...
Based on results from the SPOTLIGHT and GLOW trials, the FDA has approved first-line zolbetuximab plus fluoropyrimidine and platinum-containing chemotherapy for patients with locally advanced, unresectable, or metastatic HER2-negative gastric...
Based on results from the...
10/18/2024
Oncology
Jennifer Eads, MD, Abramson Cancer Center
Videos
Perioperative Chemotherapy Improved Survival Among Patients With Esophageal Adenocarcinoma
06/20/2024
Jennifer Eads, MD
Jennifer Eads, MD, comments on the results from the ESOPEC trial, which found perioperative chemotherapy improved survival for patients with resectable esophageal adenocarcinoma when compared with neoadjuvant chemoradiation.
Jennifer Eads, MD, comments on the results from the ESOPEC trial, which found perioperative chemotherapy improved survival for patients with resectable esophageal adenocarcinoma when compared with neoadjuvant chemoradiation.
Jennifer Eads, MD, comments on...
06/20/2024
Oncology
News
Addition of Relatlimab to Nivolumab and Chemotherapy Did Not Improve Response Among Patients With Unresectable, Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Cancer
05/23/2024

Stephanie Holland 

Stephanie Holland 
According to results from the phase 2 RELATIVITY-060 study, the addition of relatlimab to nivolumab and chemotherapy did not improve objective response among patients with unresectable, locally advanced or metastatic gastric or...
According to results from the phase 2 RELATIVITY-060 study, the addition of relatlimab to nivolumab and chemotherapy did not improve objective response among patients with unresectable, locally advanced or metastatic gastric or...
According to results from the...
05/23/2024
Oncology
Anant Ramaswamy, MD, Tata Memorial Hospital
Videos
Addition of Docetaxel to FOLFOX/CAPOX Backbone Fails to Improve OS in Advanced GEJ/Gastric Cancer
01/20/2024
Anant Ramaswamy, MD, discusses results from the phase 3 DOC-GC study which explored the efficacy of docetaxel added to a FOLFOX/CAPOX backbone for patients with advanced GEJ and gastric cancers.
Anant Ramaswamy, MD, discusses results from the phase 3 DOC-GC study which explored the efficacy of docetaxel added to a FOLFOX/CAPOX backbone for patients with advanced GEJ and gastric cancers.
Anant Ramaswamy, MD, discusses...
01/20/2024
Oncology
Yelena Janjigian, MD, Memorial Sloan Kettering Cancer Center
Videos
Global Treatment of Gastric/GEJ Cancer with Durvalumab Plus FLOT
01/19/2024
Yelena Janjigian, MD, discussed the recent subgroup analysis from the MATTERHORN study, evaluating durvalumab plus FLOT for patients with gastric or gastroesophageal junction cancer.
Yelena Janjigian, MD, discussed the recent subgroup analysis from the MATTERHORN study, evaluating durvalumab plus FLOT for patients with gastric or gastroesophageal junction cancer.
Yelena Janjigian, MD, discussed...
01/19/2024
Oncology
Conference Coverage
Docetaxel Added to Doublet Regimen Does Not Improve Survival in Advanced GEJ/Gastric Cancers
01/18/2024
The addition of docetaxel to a doublet regimen containing 5-fluorouracil/capecitabine and oxaliplatin demonstrated no improvement in OS among patients with advanced gastroesophageal junction (GEJ) and gastric cancers, according to a phase 3...
The addition of docetaxel to a doublet regimen containing 5-fluorouracil/capecitabine and oxaliplatin demonstrated no improvement in OS among patients with advanced gastroesophageal junction (GEJ) and gastric cancers, according to a phase 3...
The addition of docetaxel to a...
01/18/2024
Oncology
Conference Coverage
Addition of Durvalumab to FLOT Improved Response Rates Among Patients with Gastric or Gastroesophageal Junction Cancer Across All Regional Subgroups
01/18/2024
The improvement to pCR among patients with GC/GEJC with durvalumab plus FLOT seen in the MATTERHORN study was found to be consistent across all regional subgroups.
The improvement to pCR among patients with GC/GEJC with durvalumab plus FLOT seen in the MATTERHORN study was found to be consistent across all regional subgroups.
The improvement to pCR among...
01/18/2024
Oncology
Conference Coverage
Thoracoscopic Esophagectomy As Standard Treatment for Patients With Thoracic Esophageal Squamous Cell Carcinoma
01/18/2024
Thoracoscopic esophagectomy was found to be non-inferior in terms of OS to conventional esophagectomy among patients with thoracic esophageal squamous cell carcinoma.
Thoracoscopic esophagectomy was found to be non-inferior in terms of OS to conventional esophagectomy among patients with thoracic esophageal squamous cell carcinoma.
Thoracoscopic esophagectomy was...
01/18/2024
Oncology
Conference Coverage
Tiragolumab in Combination With Atezolizumab And Chemotherapy Shows Promise Among Patients With Esophageal Squamous Cell Carcinoma
01/18/2024
According to results from the phase 3 SKYSCRAPER-08, tiragolumab plus atezolizumab and chemotherapy improved the progression-free survival and overall survival among patients with esophageal squamous cell carcinoma.
According to results from the phase 3 SKYSCRAPER-08, tiragolumab plus atezolizumab and chemotherapy improved the progression-free survival and overall survival among patients with esophageal squamous cell carcinoma.
According to results from the...
01/18/2024
Oncology
News
Pembrolizumab Plus Chemotherapy Approved for Patients With HER2-Negative Gastric or Gastroesophageal Junction Cancer
11/17/2023
On November 16, 2023, the FDA granted approval to pembrolizumab plus chemotherapy for the treatment of patients with locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer in the first-line setting.
On November 16, 2023, the FDA granted approval to pembrolizumab plus chemotherapy for the treatment of patients with locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer in the first-line setting.
On November 16, 2023, the FDA...
11/17/2023
Oncology
Kohei Shitara, MD, PhD, National Cancer Center Hospital East
Videos
Perioperative Pembrolizumab Plus Chemotherapy for Resectable Gastric or Gastroesophageal Junction Cancer
11/14/2023
In the KEYNOTE-585 study, perioperative pembrolizumab plus chemotherapy improved the pathological complete response among patients with locally advanced, resectable gastric or gastroesophageal (G/GEJ) cancer, but not the event-free survival.
In the KEYNOTE-585 study, perioperative pembrolizumab plus chemotherapy improved the pathological complete response among patients with locally advanced, resectable gastric or gastroesophageal (G/GEJ) cancer, but not the event-free survival.
In the KEYNOTE-585 study,...
11/14/2023
Oncology

News

FDA Approval
FDA Approves Zolbetuximab Plus Chemotherapy for Patients With HER2-Negative Gastric/Gastroesophageal Junction Adenocarcinoma With CLDN18.2-Positive Tumors
10/18/2024
Based on results from the SPOTLIGHT and GLOW trials, the FDA has approved first-line zolbetuximab plus fluoropyrimidine and platinum-containing chemotherapy for patients with locally advanced, unresectable, or metastatic HER2-negative gastric...
Based on results from the SPOTLIGHT and GLOW trials, the FDA has approved first-line zolbetuximab plus fluoropyrimidine and platinum-containing chemotherapy for patients with locally advanced, unresectable, or metastatic HER2-negative gastric...
Based on results from the...
10/18/2024
Oncology
Jennifer Eads, MD, Abramson Cancer Center
Videos
Perioperative Chemotherapy Improved Survival Among Patients With Esophageal Adenocarcinoma
06/20/2024
Jennifer Eads, MD
Jennifer Eads, MD, comments on the results from the ESOPEC trial, which found perioperative chemotherapy improved survival for patients with resectable esophageal adenocarcinoma when compared with neoadjuvant chemoradiation.
Jennifer Eads, MD, comments on the results from the ESOPEC trial, which found perioperative chemotherapy improved survival for patients with resectable esophageal adenocarcinoma when compared with neoadjuvant chemoradiation.
Jennifer Eads, MD, comments on...
06/20/2024
Oncology
News
Addition of Relatlimab to Nivolumab and Chemotherapy Did Not Improve Response Among Patients With Unresectable, Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Cancer
05/23/2024

Stephanie Holland 

Stephanie Holland 
According to results from the phase 2 RELATIVITY-060 study, the addition of relatlimab to nivolumab and chemotherapy did not improve objective response among patients with unresectable, locally advanced or metastatic gastric or...
According to results from the phase 2 RELATIVITY-060 study, the addition of relatlimab to nivolumab and chemotherapy did not improve objective response among patients with unresectable, locally advanced or metastatic gastric or...
According to results from the...
05/23/2024
Oncology
Anant Ramaswamy, MD, Tata Memorial Hospital
Videos
Addition of Docetaxel to FOLFOX/CAPOX Backbone Fails to Improve OS in Advanced GEJ/Gastric Cancer
01/20/2024
Anant Ramaswamy, MD, discusses results from the phase 3 DOC-GC study which explored the efficacy of docetaxel added to a FOLFOX/CAPOX backbone for patients with advanced GEJ and gastric cancers.
Anant Ramaswamy, MD, discusses results from the phase 3 DOC-GC study which explored the efficacy of docetaxel added to a FOLFOX/CAPOX backbone for patients with advanced GEJ and gastric cancers.
Anant Ramaswamy, MD, discusses...
01/20/2024
Oncology
Yelena Janjigian, MD, Memorial Sloan Kettering Cancer Center
Videos
Global Treatment of Gastric/GEJ Cancer with Durvalumab Plus FLOT
01/19/2024
Yelena Janjigian, MD, discussed the recent subgroup analysis from the MATTERHORN study, evaluating durvalumab plus FLOT for patients with gastric or gastroesophageal junction cancer.
Yelena Janjigian, MD, discussed the recent subgroup analysis from the MATTERHORN study, evaluating durvalumab plus FLOT for patients with gastric or gastroesophageal junction cancer.
Yelena Janjigian, MD, discussed...
01/19/2024
Oncology
Conference Coverage
Docetaxel Added to Doublet Regimen Does Not Improve Survival in Advanced GEJ/Gastric Cancers
01/18/2024
The addition of docetaxel to a doublet regimen containing 5-fluorouracil/capecitabine and oxaliplatin demonstrated no improvement in OS among patients with advanced gastroesophageal junction (GEJ) and gastric cancers, according to a phase 3...
The addition of docetaxel to a doublet regimen containing 5-fluorouracil/capecitabine and oxaliplatin demonstrated no improvement in OS among patients with advanced gastroesophageal junction (GEJ) and gastric cancers, according to a phase 3...
The addition of docetaxel to a...
01/18/2024
Oncology
Conference Coverage
Addition of Durvalumab to FLOT Improved Response Rates Among Patients with Gastric or Gastroesophageal Junction Cancer Across All Regional Subgroups
01/18/2024
The improvement to pCR among patients with GC/GEJC with durvalumab plus FLOT seen in the MATTERHORN study was found to be consistent across all regional subgroups.
The improvement to pCR among patients with GC/GEJC with durvalumab plus FLOT seen in the MATTERHORN study was found to be consistent across all regional subgroups.
The improvement to pCR among...
01/18/2024
Oncology
Conference Coverage
Thoracoscopic Esophagectomy As Standard Treatment for Patients With Thoracic Esophageal Squamous Cell Carcinoma
01/18/2024
Thoracoscopic esophagectomy was found to be non-inferior in terms of OS to conventional esophagectomy among patients with thoracic esophageal squamous cell carcinoma.
Thoracoscopic esophagectomy was found to be non-inferior in terms of OS to conventional esophagectomy among patients with thoracic esophageal squamous cell carcinoma.
Thoracoscopic esophagectomy was...
01/18/2024
Oncology
Conference Coverage
Tiragolumab in Combination With Atezolizumab And Chemotherapy Shows Promise Among Patients With Esophageal Squamous Cell Carcinoma
01/18/2024
According to results from the phase 3 SKYSCRAPER-08, tiragolumab plus atezolizumab and chemotherapy improved the progression-free survival and overall survival among patients with esophageal squamous cell carcinoma.
According to results from the phase 3 SKYSCRAPER-08, tiragolumab plus atezolizumab and chemotherapy improved the progression-free survival and overall survival among patients with esophageal squamous cell carcinoma.
According to results from the...
01/18/2024
Oncology
News
Pembrolizumab Plus Chemotherapy Approved for Patients With HER2-Negative Gastric or Gastroesophageal Junction Cancer
11/17/2023
On November 16, 2023, the FDA granted approval to pembrolizumab plus chemotherapy for the treatment of patients with locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer in the first-line setting.
On November 16, 2023, the FDA granted approval to pembrolizumab plus chemotherapy for the treatment of patients with locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer in the first-line setting.
On November 16, 2023, the FDA...
11/17/2023
Oncology
News
Intraoperative Radiation Therapy May Improve Survival For Certain Patients With Recurrent Cervical or Endometrial Cancer
11/14/2024
According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.
According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.
According to a retrospective...
11/14/2024
Oncology
News
Amrubicin Plus Irinotecan Demonstrates Promising Efficacy, Safety for Chemotherapy-Naïve Patients With Extensive-Disease Small Cell Lung Cancer
11/14/2024
According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.
According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.
According to results from the...
11/14/2024
Oncology
News
Addition of Bempegaldesleukin to Nivolumab Does Not Benefit Cisplatin-Ineligible Patients With First-Line Advanced Urothelial Carcinoma
11/13/2024
Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.
Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.
Results from the phase 2...
11/13/2024
Oncology
News
Mirdametinib for Adult and Pediatric Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas
11/12/2024
According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...
According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...
According to a phase 2b trial,...
11/12/2024
Oncology
News
Epirubicin Plus Cyclophosphamide and Docetaxel Reduces Long-Term Risk of Recurrence for Patients With TOP2A Normal Early Breast Cancer
11/12/2024
According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.
According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.
According to final results from...
11/12/2024
Oncology
News
Pembrolizumab Plus Chemotherapy For Patients With High-Risk Endometrial Cancer
11/11/2024
According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.
According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.
According to results from a...
11/11/2024
Oncology
FDA Approval
FDA Grants Approval to Obecabtagene Autoleucel for R/R B-Cell Precursor Acute Lymphoblastic Leukemia
11/08/2024
On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
On November 8, 2024, the FDA...
11/08/2024
Oncology
News
Naporafenib in Combination With Rineterkib or Tremetinib for KRAS- or BRAF-Mutant Non-Small Cell Lung Cancer
11/07/2024
While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.
While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.
While naporafenib plus...
11/07/2024
Oncology
News
Addition of Concurrent Thoracic Radiotherapy to First-Line TKI Therapy Improves Survival for Patients With EGFR-Mutated Non-Small Cell Lung Cancer
11/06/2024
According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.
According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.
According to results from a...
11/06/2024
Oncology
News
Ipilimumab After PD-1 Inhibition Failure Among Patients With Metastatic Melanoma
11/05/2024
A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.
A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.
A single-center real-world study...
11/05/2024
Oncology

Interactive Features

Quiz
Osimertinib For Progressive EGFR-Mutated T790M-Negative NSCLC
04/25/2023
How did patients with EGFR-mutated T790M-negative non-small cell lung cancer that had progressed after treatment with TKIs and chemotherapy respond to osimertinib?
How did patients with EGFR-mutated T790M-negative non-small cell lung cancer that had progressed after treatment with TKIs and chemotherapy respond to osimertinib?
How did patients with...
04/25/2023
Oncology
Test Your Knowledge
L858R Mutation by Stage in EGFR-Mutated Lung Cancer
04/13/2023
Is there a difference in L858R mutation rates in EGFR-mutated lung cancer when stratified by stage?
Is there a difference in L858R mutation rates in EGFR-mutated lung cancer when stratified by stage?
Is there a difference in L858R...
04/13/2023
Oncology
Quiz
Are PD-L1 Scores Predictive of TP53 Mutation Rates?
02/13/2023
A study investigated a potential link between PD-L1 scores and TP53 tumor mutation.
A study investigated a potential link between PD-L1 scores and TP53 tumor mutation.
A study investigated a potential...
02/13/2023
Oncology
Quiz
Quiz: Targeted Therapies for EGFR-Mutant Lung Cancer
12/02/2022
What study recently provided an additional 2 years of data to support adjuvant osimertinib as treatment of EGFR-mutant lung cancer?
What study recently provided an additional 2 years of data to support adjuvant osimertinib as treatment of EGFR-mutant lung cancer?
What study recently provided an...
12/02/2022
Oncology
Test Your Knowledge
Quiz: Combination Therapies as Treatment Options for EGFR-Mutated Lung Cancer
11/30/2022
Which combination therapies are currently being evaluated in clinical trials as treatment options for patients with EGFR-mutated lung cancer?
Which combination therapies are currently being evaluated in clinical trials as treatment options for patients with EGFR-mutated lung cancer?
Which combination therapies are...
11/30/2022
Oncology
Quiz
Quiz: Which somatic missense non-synonymous single nucleotide polymorphisms were recently determined to be putative novel rare genetic markers for NSCLC?
10/12/2022
After analyzing a selected pool of oncogenes, which somatic missense non-synonymous single nucleotide polymorphisms did a first-of-its-kind study find to be deleterious in patients with non-small cell lung cancer?
After analyzing a selected pool of oncogenes, which somatic missense non-synonymous single nucleotide polymorphisms did a first-of-its-kind study find to be deleterious in patients with non-small cell lung cancer?
After analyzing a selected pool...
10/12/2022
Oncology
Quiz
Quiz: Amivantamab Outcomes vs Other Real-World Therapies for EGFR-Mutated NSCLC
07/25/2022
In the single-arm CHRYSALIS study, among patients with EGFR exon 20 insertion-mutated advanced NSCLC who progressed after platinum-based chemotherapy, what outcome did not improve when treated with amivantamab vs real-world therapies?
In the single-arm CHRYSALIS study, among patients with EGFR exon 20 insertion-mutated advanced NSCLC who progressed after platinum-based chemotherapy, what outcome did not improve when treated with amivantamab vs real-world therapies?
In the single-arm CHRYSALIS...
07/25/2022
Oncology
Medical
Test Your Knowledge
Quiz: How Does Tisagenlecleucel Affect Activity in ALL?
03/07/2022
True or false: Tisagenlecleucel does not affect activity in young patients with R/R B-cell ALL and adult patients with R/R DLBCL.
True or false: Tisagenlecleucel does not affect activity in young patients with R/R B-cell ALL and adult patients with R/R DLBCL.
True or false: Tisagenlecleucel...
03/07/2022
Oncology
Test Your Knowledge
Quiz: Is This Selective FGFR Inhibitor Safe to Treat Hematologic Malignancies?
02/25/2022
True or false: The FIGHT-101 trial revealed pemigatinib is unsafe for patients with FGFR mutant hematologic malignancies.
True or false: The FIGHT-101 trial revealed pemigatinib is unsafe for patients with FGFR mutant hematologic malignancies.
True or false: The FIGHT-101...
02/25/2022
Oncology
Test Your Knowledge
Quiz: Does This Pan-FGFR TKI Show Long-Term Efficacy?
02/25/2022
True or false: Erdafitinib, a pan-FGFR TKI, showed long-term efficacy for advanced urothelial carcinoma.
True or false: Erdafitinib, a pan-FGFR TKI, showed long-term efficacy for advanced urothelial carcinoma.
True or false: Erdafitinib, a...
02/25/2022
Oncology

Recent News

FDA Approval
FDA Approves Zolbetuximab Plus Chemotherapy for Patients With HER2-Negative Gastric/Gastroesophageal Junction Adenocarcinoma With CLDN18.2-Positive Tumors
10/18/2024
Based on results from the SPOTLIGHT and GLOW trials, the FDA has approved first-line zolbetuximab plus fluoropyrimidine and platinum-containing chemotherapy for patients with locally advanced, unresectable, or metastatic HER2-negative gastric...
Based on results from the SPOTLIGHT and GLOW trials, the FDA has approved first-line zolbetuximab plus fluoropyrimidine and platinum-containing chemotherapy for patients with locally advanced, unresectable, or metastatic HER2-negative gastric...
Based on results from the...
10/18/2024
Oncology
News
Addition of Relatlimab to Nivolumab and Chemotherapy Did Not Improve Response Among Patients With Unresectable, Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Cancer
05/23/2024

Stephanie Holland 

Stephanie Holland 
According to results from the phase 2 RELATIVITY-060 study, the addition of relatlimab to nivolumab and chemotherapy did not improve objective response among patients with unresectable, locally advanced or metastatic gastric or...
According to results from the phase 2 RELATIVITY-060 study, the addition of relatlimab to nivolumab and chemotherapy did not improve objective response among patients with unresectable, locally advanced or metastatic gastric or...
According to results from the...
05/23/2024
Oncology
News
Pembrolizumab Plus Chemotherapy Approved for Patients With HER2-Negative Gastric or Gastroesophageal Junction Cancer
11/17/2023
On November 16, 2023, the FDA granted approval to pembrolizumab plus chemotherapy for the treatment of patients with locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer in the first-line setting.
On November 16, 2023, the FDA granted approval to pembrolizumab plus chemotherapy for the treatment of patients with locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer in the first-line setting.
On November 16, 2023, the FDA...
11/17/2023
Oncology
News
Trastuzumab Plus Ramucirumab and Paclitaxel Shows Promise Among Patients With Second-Line HER2-Positive, Advanced Gastric or Gastroesophageal Junction Cancer
08/10/2023
In a phase 1b/2 study, trastuzumab plus ramucirumab and paclitaxel showed promise in the second-line setting for patients with HER2-positive gastric or gastroesophageal junction cancer.
In a phase 1b/2 study, trastuzumab plus ramucirumab and paclitaxel showed promise in the second-line setting for patients with HER2-positive gastric or gastroesophageal junction cancer.
In a phase 1b/2 study,...
08/10/2023
Oncology
News
Frontline Tislelizumab Plus Chemotherapy for Patients With Gastroesophageal Squamous Cell Carcinoma
05/23/2023
In a phase 3 trial, tislelizumab plus chemotherapy improved the overall survival of patients with advanced or metastatic gastroesophageal squamous cell carcinoma when compared with placebo plus chemotherapy.
In a phase 3 trial, tislelizumab plus chemotherapy improved the overall survival of patients with advanced or metastatic gastroesophageal squamous cell carcinoma when compared with placebo plus chemotherapy.
In a phase 3 trial, tislelizumab...
05/23/2023
Oncology
News
Zolbetuximab Plus CAPOX Improves Survival in Gastric/Gastroesophageal Junction Cancers
03/25/2023
Zolbetuximab in combination with chemotherapy increases survival in patients with first-line claudin-18.2-positive/HER2-negative locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma.
Zolbetuximab in combination with chemotherapy increases survival in patients with first-line claudin-18.2-positive/HER2-negative locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma.
Zolbetuximab in combination with...
03/25/2023
Oncology
News
Potential of Sintilimab Plus Apatinib and Chemotherapy in Gastric or Gastroesophageal Junction Cancer
03/20/2023
In a phase 2 study, sintilimab plus apatinib and chemotherapy demonstrated anti-tumor activity and tolerable safety among patients with gastric or gastroesophageal junction cancer.
In a phase 2 study, sintilimab plus apatinib and chemotherapy demonstrated anti-tumor activity and tolerable safety among patients with gastric or gastroesophageal junction cancer.
In a phase 2 study, sintilimab...
03/20/2023
Oncology
News
Perioperative Nivolumab Plus Ipilimumab for dMMR/MSI-H Gastric/Gastroesophageal Junction Adenocarcinoma
03/02/2023
Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab was associated with high pathological complete response with no unexpected toxicities for patient with dMMR/MSI-H gastric/gastroesophageal junction adenocarcinoma.
Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab was associated with high pathological complete response with no unexpected toxicities for patient with dMMR/MSI-H gastric/gastroesophageal junction adenocarcinoma.
Neoadjuvant nivolumab plus...
03/02/2023
Oncology
News
Adding Atezolizumab to Modified FOLFOX May Improve Response Rates in Gastroesophageal Junction Cancer
02/10/2023
The addition of atezolizumab to modified FOLFOX in the perioperative setting was found to be safe and may improve response rates for patients with gastroesophageal junction cancer.
The addition of atezolizumab to modified FOLFOX in the perioperative setting was found to be safe and may improve response rates for patients with gastroesophageal junction cancer.
The addition of atezolizumab to...
02/10/2023
Oncology
News
Potential of Overlap Guiding Tube-Assisted Method of Esophagojejunostomy for Gastric/Gastroesophageal Junction Cancer
02/08/2023
Study findings reveal the overlap guided tube-assisted method of esophagojejunostomy for gastric/gastroesophageal junction cancer is associated with reduced surgical difficulty vs the conventional method.
Study findings reveal the overlap guided tube-assisted method of esophagojejunostomy for gastric/gastroesophageal junction cancer is associated with reduced surgical difficulty vs the conventional method.
Study findings reveal the...
02/08/2023
Oncology
News
Intraoperative Radiation Therapy May Improve Survival For Certain Patients With Recurrent Cervical or Endometrial Cancer
11/14/2024
According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.
According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.
According to a retrospective...
11/14/2024
Oncology
News
Amrubicin Plus Irinotecan Demonstrates Promising Efficacy, Safety for Chemotherapy-Naïve Patients With Extensive-Disease Small Cell Lung Cancer
11/14/2024
According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.
According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.
According to results from the...
11/14/2024
Oncology
News
Addition of Bempegaldesleukin to Nivolumab Does Not Benefit Cisplatin-Ineligible Patients With First-Line Advanced Urothelial Carcinoma
11/13/2024
Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.
Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.
Results from the phase 2...
11/13/2024
Oncology
News
Mirdametinib for Adult and Pediatric Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas
11/12/2024
According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...
According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...
According to a phase 2b trial,...
11/12/2024
Oncology
News
Epirubicin Plus Cyclophosphamide and Docetaxel Reduces Long-Term Risk of Recurrence for Patients With TOP2A Normal Early Breast Cancer
11/12/2024
According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.
According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.
According to final results from...
11/12/2024
Oncology
News
Pembrolizumab Plus Chemotherapy For Patients With High-Risk Endometrial Cancer
11/11/2024
According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.
According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.
According to results from a...
11/11/2024
Oncology
FDA Approval
FDA Grants Approval to Obecabtagene Autoleucel for R/R B-Cell Precursor Acute Lymphoblastic Leukemia
11/08/2024
On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
On November 8, 2024, the FDA...
11/08/2024
Oncology
News
Naporafenib in Combination With Rineterkib or Tremetinib for KRAS- or BRAF-Mutant Non-Small Cell Lung Cancer
11/07/2024
While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.
While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.
While naporafenib plus...
11/07/2024
Oncology
News
Addition of Concurrent Thoracic Radiotherapy to First-Line TKI Therapy Improves Survival for Patients With EGFR-Mutated Non-Small Cell Lung Cancer
11/06/2024
According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.
According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.
According to results from a...
11/06/2024
Oncology
News
Ipilimumab After PD-1 Inhibition Failure Among Patients With Metastatic Melanoma
11/05/2024
A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.
A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.
A single-center real-world study...
11/05/2024
Oncology

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