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FLT3 Biological Pathways Reviews

Videos

Musa Yilmaz, MD
Videos
Triplet Combo Highly Active in Relapsed/Refractory FLT3-Mutated AML
11/03/2021
Musa Yilmaz, MD, discusses a highly active triplet combination for patients with FLT3-ITD mutated AML. These data were presented at the 2021 ASCO Annual Meeting.
Musa Yilmaz, MD, discusses a highly active triplet combination for patients with FLT3-ITD mutated AML. These data were presented at the 2021 ASCO Annual Meeting.
Musa Yilmaz, MD, discusses a...
11/03/2021
Oncology
Mark Levis, MD, PhD
Videos
Mark Levis, MD, PhD, Discusses FLT3 Inhibition in Relapsed/Refractory AML
06/05/2021
Dr Levis discusses a study examining FF-10101-01, an irreversible FLT3 inhibitor, in patients with relapsed/refractory AML, which was presented at the 2021 ASCO Annual Meeting.
Dr Levis discusses a study examining FF-10101-01, an irreversible FLT3 inhibitor, in patients with relapsed/refractory AML, which was presented at the 2021 ASCO Annual Meeting.
Dr Levis discusses a study...
06/05/2021
Oncology
Real-World Treatment Patterns, FLT3 Testing, and Outcomes in AML
Videos
Real-World Treatment Patterns, FLT3 Testing, and Outcomes in AML
01/14/2021
Amer Zeidan, MBBS, MHS, discusses results from a retrospective study examining FLT3 testing trends, treatment patterns, and overall survival in relapsed/refractory AML.
Amer Zeidan, MBBS, MHS, discusses results from a retrospective study examining FLT3 testing trends, treatment patterns, and overall survival in relapsed/refractory AML.
Amer Zeidan, MBBS, MHS,...
01/14/2021
Journal of Clinical Pathways
Sameera Kumar, MD
Conference Coverage
Radiation for Patients With Stage 3 Non-Small Cell Lung Cancer
03/27/2025
Sameera Kumar, MD, highlights the role radiation plays in the treatment of patients with stage 3 non-small cell lung cancer.
Sameera Kumar, MD, highlights the role radiation plays in the treatment of patients with stage 3 non-small cell lung cancer.
Sameera Kumar, MD, highlights...
03/27/2025
Oncology
William Grady, MD
Conference Coverage
Biomarker-Based Testing vs Colonoscopy for Colorectal Cancer Screening
03/27/2025
William Grady, MD, compares biomarker-based testing and colonoscopy when considering options for colorectal cancer screening.
William Grady, MD, compares biomarker-based testing and colonoscopy when considering options for colorectal cancer screening.
William Grady, MD, compares...
03/27/2025
Oncology
Estelamari Rodriguez, MD, MPH
Conference Coverage
First-Line CTLA-4 Inhibitors for Patients With Non-Small Cell Lung Cancer
03/27/2025
Estelamari Rodriguez, MD, MPH, assesses the potential of CTLA-4 inhibitors in the first-line setting for patients with non-small cell lung cancer.
Estelamari Rodriguez, MD, MPH, assesses the potential of CTLA-4 inhibitors in the first-line setting for patients with non-small cell lung cancer.
Estelamari Rodriguez, MD, MPH,...
03/27/2025
Oncology
Deborah Doroshow, MD, PhD
Conference Coverage
Immunotherapy for Patients With Small Cell Lung Cancer
03/27/2025
Deborah Doroshow, MD, PhD
Deborah Doroshow, MD, PhD, discusses the role of immunotherapy when treating patients with small cell lung cancer.
Deborah Doroshow, MD, PhD, discusses the role of immunotherapy when treating patients with small cell lung cancer.
Deborah Doroshow, MD, PhD,...
03/27/2025
Oncology
Ian Tobal, DO, Ochsner Medical Center
Videos
Real World Child-Pugh Scores of Patients With HCC Receiving Immunotherapy
03/27/2025
Ian Tobal, DO, discusses an analysis of real-world Child-Pugh score and outcomes among patients undergoing treatment for hepatocellular carcinoma.
Ian Tobal, DO, discusses an analysis of real-world Child-Pugh score and outcomes among patients undergoing treatment for hepatocellular carcinoma.
Ian Tobal, DO, discusses an...
03/27/2025
Oncology
Reid Ness, MD, MPH
Conference Coverage
Assessing Evidence for Colonoscopy as a Primary Screening Tool
03/27/2025
Reid Ness, MD, MPH, discusses the nordICC trial, which assessed the efficacy of using colonoscopy as a primary screening tool.
Reid Ness, MD, MPH, discusses the nordICC trial, which assessed the efficacy of using colonoscopy as a primary screening tool.
Reid Ness, MD, MPH, discusses...
03/27/2025
Oncology
Vivek Subbiah, MD
Conference Coverage
Tumor Agnostic Therapies for Patients With Solid Tumors
03/27/2025
Vivek Subbiah, MD
Vivek Subbiah, MD, discusses advances in tumor agnostic therapies and explores how these therapies can shift the treatment landscape for patients with solid tumors.
Vivek Subbiah, MD, discusses advances in tumor agnostic therapies and explores how these therapies can shift the treatment landscape for patients with solid tumors.
Vivek Subbiah, MD, discusses...
03/27/2025
Oncology
Reid Ness, MD, MPH
Conference Coverage
Colonoscopy for the Detection of Colorectal Cancer
03/27/2025
Reid Ness, MD, MPH, argues that colonoscopy is superior compared to biomarker-based testing for the detection of colorectal cancer.
Reid Ness, MD, MPH, argues that colonoscopy is superior compared to biomarker-based testing for the detection of colorectal cancer.
Reid Ness, MD, MPH, argues that...
03/27/2025
Oncology
Shipra Gandhi, MD, Winship Cancer Institute
Videos
An Argument Against Earlier Novel Endocrine Backbones for Breast Cancer
03/27/2025
Shipra Gandhi, MD
Shipra Gandhi, MD, makes the case against moving novel endocrine backbones to earlier lines of therapy in breast cancer.
Shipra Gandhi, MD, makes the case against moving novel endocrine backbones to earlier lines of therapy in breast cancer.
Shipra Gandhi, MD, makes the...
03/27/2025
Oncology
Raghav Sundar, MD, PhD, Yale Cancer Center
Videos
Integrating Anatomy Into Treatment Decisions for Gastrointestinal Cancers
03/27/2025
Raghav Sundar, MD, PhD, discusses the importance of considering tumor biology and anatomic site when determining treatments for patients with gastrointestinal cancers.
Raghav Sundar, MD, PhD, discusses the importance of considering tumor biology and anatomic site when determining treatments for patients with gastrointestinal cancers.
Raghav Sundar, MD, PhD,...
03/27/2025
Oncology
OLN

FLT3

ALIASES

Cluster of differentiation antigen 135; CD135; fms like tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; fetal liver kinase-2

References

FLT-3 is a receptor tyrosine kinase that activates pathways leading to the proliferation, differentiation, and apoptosis of hematopoietic cells.1,2 FLT3-ITD mutations and FLT3-TKD mutations can lead to the production of FLT-3 ligands resulting in the activation of FLT-3 and subsequently triggers PI3K and RAS signaling pathways.3

Expression Percentages per Cancer Type

ALL
3%
AML
30%
Breast Cancer
14%
Cervical Cancer
2%
Lung Cancer
1%
Melanoma
6%
MDS
10%
Ovarian Cancer
1%

Resources

News
Sorafenib Maintenance Post-Transplantation Among Patients With FLT3-ITD Mutated AML
04/15/2023
Jordan Kadish
According to a phase 3 trial, sorafenib maintenance post-transplantation yielded safe results among patients with FLT3-ITD mutated AM undergoing allogeneic hematopoietic stem cell transplantation.
According to a phase 3 trial, sorafenib maintenance post-transplantation yielded safe results among patients with FLT3-ITD mutated AM undergoing allogeneic hematopoietic stem cell transplantation.
According to a phase 3 trial,...
04/15/2023
Oncology
News
Venetoclax Plus Gilteritinib Among Patients With FLT3-Mutated AML
03/30/2023
Jordan Kadish
According to findings of a phase 1b study, venetoclax plus gilteritinib resulted in a high modified composite complete response and molecular response rates among patients with R/R FLT3-mutated AML.
According to findings of a phase 1b study, venetoclax plus gilteritinib resulted in a high modified composite complete response and molecular response rates among patients with R/R FLT3-mutated AML.
According to findings of a phase...
03/30/2023
Oncology
News
Gilteritinib Plus Azacitidine Among Patients With FLT3-Mutated AML
03/27/2023
Jordan Kadish
Gilteritinib plus azacitidine yielded higher composite complete remission rates than azacitidine treatment alone among patients with FLT3-mutated acute myeloid leukemia ineligible for intensive chemotherapy.
Gilteritinib plus azacitidine yielded higher composite complete remission rates than azacitidine treatment alone among patients with FLT3-mutated acute myeloid leukemia ineligible for intensive chemotherapy.
Gilteritinib plus azacitidine...
03/27/2023
Oncology
News
Modakafusp Alfa Demonstrates Antitumor Activity Among Patients With Relapsed/Refractory Multiple Myeloma
04/02/2025
Emily Estrada
At a tolerable and safe dose, the anti-CD38 antibody, modakafusp alfa demonstrated decreased tumor activity and immune activation among patients with relapsed/refractory multiple myeloma.
At a tolerable and safe dose, the anti-CD38 antibody, modakafusp alfa demonstrated decreased tumor activity and immune activation among patients with relapsed/refractory multiple myeloma.
At a tolerable and safe dose,...
04/02/2025
Oncology
News
Quadruplet Therapy Demonstrates Efficacy for Treatment of Transplant-Ineligible Newly Diagnosed Multiple Myeloma
04/02/2025
Emily Estrada
Quadruplet therapy with isatuximab, weekly bortezomib, lenalidomide, and limited dexamethasone demonstrated safety and efficacy for older patients with transplant-ineligible MM in a phase 2 clinical trial.
Quadruplet therapy with isatuximab, weekly bortezomib, lenalidomide, and limited dexamethasone demonstrated safety and efficacy for older patients with transplant-ineligible MM in a phase 2 clinical trial.
Quadruplet therapy with...
04/02/2025
Oncology
News
Co-Occurrence of High-Risk Cytogenetic Abnormalities as a Predictive Marker for Multiple Myeloma
04/02/2025
Emily Estrada
The presence of 2 or more high-risk cytogenetic abnormalities among patients with multiple myeloma was associated with poor survival outcomes, according to a systematic review and meta-analysis.
The presence of 2 or more high-risk cytogenetic abnormalities among patients with multiple myeloma was associated with poor survival outcomes, according to a systematic review and meta-analysis.
The presence of 2 or more...
04/02/2025
Oncology
News
Pembrolizumab Plus Bevacizumab Shows Promise Among Previously Untreated Patients With Melanoma Brain Metastases
04/01/2025
Stephanie Holland
According to results from a phase 2 study, pembrolizumab plus bevacizumab demonstrated promise among previously untreated patients with melanoma brain metastases.
According to results from a phase 2 study, pembrolizumab plus bevacizumab demonstrated promise among previously untreated patients with melanoma brain metastases.
According to results from a...
04/01/2025
Oncology
News
Outcomes Without Adjuvant Radioactive Iodine Among Pediatric Patients With Papillary Thyroid Cancer
04/01/2025
Allison Casey
According to a retrospective cohort study, omitting adjuvant radioactive iodine therapy for pediatric patients with papillary thyroid cancer did not compromise outcomes.
According to a retrospective cohort study, omitting adjuvant radioactive iodine therapy for pediatric patients with papillary thyroid cancer did not compromise outcomes.
According to a retrospective...
04/01/2025
Oncology
News
Lenvatinib Plus High-Dose Radioiodine Therapy Shows Promise for Patients With Metastatic Well-Differentiated Thyroid Cancer
04/01/2025
Allison Casey
A study found the addition of lenvatinib to high-dose radioiodine therapy showed promise in improving response for patients with metastatic well-differentiated radioiodine-avid thyroid cancer.
A study found the addition of lenvatinib to high-dose radioiodine therapy showed promise in improving response for patients with metastatic well-differentiated radioiodine-avid thyroid cancer.
A study found the addition of...
04/01/2025
Oncology
News
Zenocutuzumab Demonstrates Durable Activity in NRG1 Fusion–Positive Solid Tumors
03/31/2025
Janelle Bradley
Findings from a phase 2 study show zenocutuzumab demonstrated durable clinical activity and a favorable safety profile in patients with NRG1 fusion–positive solid tumors, particularly non–small-cell lung and pancreatic cancers.
Findings from a phase 2 study show zenocutuzumab demonstrated durable clinical activity and a favorable safety profile in patients with NRG1 fusion–positive solid tumors, particularly non–small-cell lung and pancreatic cancers.
Findings from a phase 2 study...
03/31/2025
Oncology
FDA Approval
Durvalumab Approved for Muscle Invasive Bladder Cancer
03/31/2025
Allison Casey
The US FDA approved neoadjuvant durvalumab plus gemcitabine-cisplatin followed by adjuvant durvalumab after radical cystectomy for patients with muscle invasive bladder cancer.
The US FDA approved neoadjuvant durvalumab plus gemcitabine-cisplatin followed by adjuvant durvalumab after radical cystectomy for patients with muscle invasive bladder cancer.
The US FDA approved neoadjuvant...
03/31/2025
Oncology
FDA Approval
FDA Expands Approval of Lutetium Lu 177 Vipivotide Tetraxetan for Metastatic Castration-Resistant Prostate Cancer
03/28/2025
Stephanie Holland
Based on results from the PSMAfore trial, the FDA has expanded the approval of lutetium Lu 177 vipivotide tetraxetan to include patients with PSMA-positive metastatic castration-resistant prostate cancer previously treated with ARPIs and...
Based on results from the PSMAfore trial, the FDA has expanded the approval of lutetium Lu 177 vipivotide tetraxetan to include patients with PSMA-positive metastatic castration-resistant prostate cancer previously treated with ARPIs and...
Based on results from the...
03/28/2025
Oncology
FDA Approval
FDA Approves Cabozantinib for Patients With Locally Advanced or Metastatic Well-Differentiated pNETs and epNETs
03/26/2025
Stephanie Holland
Based on results from the CABINET trial, the FDA has approved cabozantinib for patients 12 years of age and older with unresectable locally advanced or metastatic well-differentiated pNETs and epNETs who experienced disease progression after...
Based on results from the CABINET trial, the FDA has approved cabozantinib for patients 12 years of age and older with unresectable locally advanced or metastatic well-differentiated pNETs and epNETs who experienced disease progression after...
Based on results from the...
03/26/2025
Oncology

Podcasts

Petros Grivas, MD, PhD, Fred Hutchinson Cancer Center
Podcasts
Sacituzumab Govitecan Plus Pembrolizumab in the TROPHY-U-01 Trial
03/07/2024

Featured Petros Grivas, MD, PhD

Featured Petros Grivas, MD, PhD ...
Petros Grivas, MD, PhD, shares results from the phase 2 TROPHY-U-01 study evaluating sacituzumab govetican plus pembrolizumab among patients with metastatic urothelial carcinoma following progression on platinum-chemotherapy.
Petros Grivas, MD, PhD, shares results from the phase 2 TROPHY-U-01 study evaluating sacituzumab govetican plus pembrolizumab among patients with metastatic urothelial carcinoma following progression on platinum-chemotherapy.
Petros Grivas, MD, PhD, shares...
03/07/2024
Oncology
Sara Hurvitz, MD, David Geffen School of Medicine – UCLA, Los Angeles, CA
Podcasts
Neoadjuvant Chemotherapy Plus HER2-Targeted Therapy for Early Stage HER2-Positive Breast Cancer
02/16/2023
Sara Hurvitz, MD, shares how she would treat a patient with early stage HER2-positive breast cancer.
Sara Hurvitz, MD, shares how she would treat a patient with early stage HER2-positive breast cancer.
Sara Hurvitz, MD, shares how she...
02/16/2023
Oncology
Michael Hall, MD, Fox Chase Cancer Center
Podcasts
Advances in Genetic Testing for Patients With Gastrointestinal Cancers
12/20/2022
Michael Hall, MD, reviews his presentation from the 2022 Great Debates & Updates in Gastrointestinal Malignancies virtual meeting, on genetic testing for gastrointestinal cancers.
Michael Hall, MD, reviews his presentation from the 2022 Great Debates & Updates in Gastrointestinal Malignancies virtual meeting, on genetic testing for gastrointestinal cancers.
Michael Hall, MD, reviews his...
12/20/2022
Oncology
Petros Grivas, MD, PhD, Fred Hutchinson Cancer Center
Podcasts
Enfortumab Vedotin for Metastatic Urothelial Cancer After Progression on Platinum-Based Chemotherapy
11/15/2022
Petros Grivas, MD, PhD, shares how he would treat a patient who presented with a new diagnosis of metastatic urothelial cancer and progressed after completing a gemcitabine-cisplatin chemotherapy regimen.
Petros Grivas, MD, PhD, shares how he would treat a patient who presented with a new diagnosis of metastatic urothelial cancer and progressed after completing a gemcitabine-cisplatin chemotherapy regimen.
Petros Grivas, MD, PhD, shares...
11/15/2022
Oncology
OLN favicon
Podcasts
BRCAness May Predict Response to Platinum-Based Chemotherapy in Intrahepatic Cholangiocarcinoma
07/29/2022
Margherita Rimini, MD, discusses findings from an analysis exploring the association between the BRCAness phenotype and response to platinum-based chemotherapy among patients with intrahepatic cholangiocarcinoma.
Margherita Rimini, MD, discusses findings from an analysis exploring the association between the BRCAness phenotype and response to platinum-based chemotherapy among patients with intrahepatic cholangiocarcinoma.
Margherita Rimini, MD, discusses...
07/29/2022
Oncology
Ruth He, MD, Lombardi Comprehensive Cancer Center
Podcasts
Durvalumab Plus Chemotherapy Improves Outcomes in Biliary Tract Cancer Across Primary Tumor Locations
07/22/2022
Ruth He, MD, discusses findings from a subgroup analysis which evaluated outcomes of patients with biliary tract cancer receiving durvalumab plus chemotherapy by primary tumor location: intrahepatic or extrahepatic cholangiocarcinoma or...
Ruth He, MD, discusses findings from a subgroup analysis which evaluated outcomes of patients with biliary tract cancer receiving durvalumab plus chemotherapy by primary tumor location: intrahepatic or extrahepatic cholangiocarcinoma or...
Ruth He, MD, discusses findings...
07/22/2022
Oncology
Arndt Vogel, MD, Hannover Medical School
Podcasts
Pemigatinib for Cholangiocarcinoma with FGFR2 Fusions or Rearrangements
07/14/2022
Arndt Vogel, MD, shares results from the phase 2, FIGHT-202 trial which evaluated pemigatinib in patients with previously treated, locally advanced or metastatic cholangiocarcinoma.
Arndt Vogel, MD, shares results from the phase 2, FIGHT-202 trial which evaluated pemigatinib in patients with previously treated, locally advanced or metastatic cholangiocarcinoma.
Arndt Vogel, MD, shares results...
07/14/2022
Oncology
Petros Grivas, MD, Fred Hutchinson Cancer Center
Podcasts
Sacituzumab Govitecan Plus Pembrolizumab Yields Encouraging Response Rates in Metastatic Urothelial Cancer
06/22/2022
Petros Grivas, MD, shares results from the phase 2 TROPHY-U-01 trial evaluating the sacituzumab govitecan in combination with pembrolizumab for patients with metastatic urothelial cancer who progressed after platinum-based regimens.
Petros Grivas, MD, shares results from the phase 2 TROPHY-U-01 trial evaluating the sacituzumab govitecan in combination with pembrolizumab for patients with metastatic urothelial cancer who progressed after platinum-based regimens.
Petros Grivas, MD, shares...
06/22/2022
Oncology
Robert Jones, MD
Podcasts
Maintenance Therapy With Cabozantinib Shows No Significant Benefit vs Placebo for Metastatic Urothelial Carcinoma
06/21/2022
Robert Jones, MD, shares results and insights from the phase 2 ATLANTIS trial, evaluating maintenance cabozantinib following platinum-based chemotherapy for patients with metastatic urothelial carcinoma.
Robert Jones, MD, shares results and insights from the phase 2 ATLANTIS trial, evaluating maintenance cabozantinib following platinum-based chemotherapy for patients with metastatic urothelial carcinoma.
Robert Jones, MD, shares results...
06/21/2022
Oncology
David O'Malley
Podcasts
Part 2: Overcoming PARP Inhibitor and Platinum Resistance in Patients With Ovarian Cancer
06/20/2022
In part 2 of this 2-part podcast series, David O'Malley, MD, Ohio State University, discusses strategies for overcoming PARP inhibitor and platinum resistance in patients with ovarian cancer.
In part 2 of this 2-part podcast series, David O'Malley, MD, Ohio State University, discusses strategies for overcoming PARP inhibitor and platinum resistance in patients with ovarian cancer.
In part 2 of this 2-part podcast...
06/20/2022
Oncology

Interactive

Quiz
GPRC5D-Targeted CAR T-Cell Therapy for Multiple Myeloma
04/02/2025
What was the reported hematologic toxicity profile of GPRC5D-targeted CAR T-cell therapy among patients with multiple myeloma?
What was the reported hematologic toxicity profile of GPRC5D-targeted CAR T-cell therapy among patients with multiple myeloma?
What was the reported...
04/02/2025
Oncology
Quiz
Central Nervous System Progression in Extensive-Stage Small Cell Lung Cancer
03/19/2025
Did atezolizumab plus etoposide and carboplatin delay time to central nervous system progression among patients with extensive-stage small cell lung cancer?
Did atezolizumab plus etoposide and carboplatin delay time to central nervous system progression among patients with extensive-stage small cell lung cancer?
Did atezolizumab plus etoposide...
03/19/2025
Oncology
Quiz
Talazoparib Plus Atezolizumab for Patients With Extensive-Stage Small Cell Lung Cancer
03/05/2025
According to results from the phase 2 SWOG S1929 study, what was the result of adding talazoparib to maintenance atezolizumab among patients with extensive-stage small cell lung cancer?
According to results from the phase 2 SWOG S1929 study, what was the result of adding talazoparib to maintenance atezolizumab among patients with extensive-stage small cell lung cancer?
According to results from the...
03/05/2025
Oncology
Quiz
Lurbinectedin for Patients With Platinum-Sensitive Small Cell Lung Cancer
02/10/2025
Did lurbinectedin demonstrate equivalent to or better efficacy than platinum rechallenge among patients with platinum-sensitive small cell lung cancer who experience relapse after treatment with platinum-based therapy?
Did lurbinectedin demonstrate equivalent to or better efficacy than platinum rechallenge among patients with platinum-sensitive small cell lung cancer who experience relapse after treatment with platinum-based therapy?
Did lurbinectedin demonstrate...
02/10/2025
Oncology
Quiz
Trastuzumab Emtansine for HER2-Positive Early Breast Cancer
02/07/2025
Did trastuzumab emtansine improve invasive disease-free survival compared to trastuzumab in patients with HER2-positive early breast cancer who had residual disease following neoadjuvant therapy?
Did trastuzumab emtansine improve invasive disease-free survival compared to trastuzumab in patients with HER2-positive early breast cancer who had residual disease following neoadjuvant therapy?
Did trastuzumab emtansine...
02/07/2025
Oncology
Quiz
Trilaciclib for Patients With Extensive-Stage Small Cell Lung Cancer
01/22/2025
Did the administration of trilaciclib prior to chemotherapy reduce the incidence of chemotherapy-induced myelosuppression among patients with extensive-stage small cell lung cancer?
Did the administration of trilaciclib prior to chemotherapy reduce the incidence of chemotherapy-induced myelosuppression among patients with extensive-stage small cell lung cancer?
Did the administration of...
01/22/2025
Oncology
Quiz
Lenvatinib Plus Pembrolizumab for Patients With Advanced or Recurrent Endometrial Cancer
12/20/2024
Do you know if first-line lenvatinib plus pembrolizumab significantly improved survival compared to lenvatinib plus chemotherapy for patients with mismatch repair-proficient advanced or recurrent endometrial cancer? Take our quiz to find out!
Do you know if first-line lenvatinib plus pembrolizumab significantly improved survival compared to lenvatinib plus chemotherapy for patients with mismatch repair-proficient advanced or recurrent endometrial cancer? Take our quiz to find out!
Do you know if first-line...
12/20/2024
Oncology
Quiz
For your patients with MF and anemia, which of the following would preclude you from initiating ruxolitinib at diagnosis?
12/13/2024
12/13/2024
Oncology
Quiz
You just diagnosed your patient with intermediate-1 primary MF. The patient has a spleen that is palpable 5 cm below the LCM; has mild disease-related symptoms; and is not anemic. What would you typically do next for a patient like this?
12/13/2024
12/13/2024
Oncology
Quiz
What is your primary treatment goal when treating your patients with MF?
12/13/2024
12/13/2024
Oncology

FLT3 Inhibitors

FLT3 inhibitors are tyrosine kinase inhiitors that inhibit the ability of the FLT3 protein to be phosphorylated, thus slowing the growth and proliferation of cancer cells. This table outlines FLT3 inhibitors both approved by the FDA and in the pipeline.

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FLT3 Inhibitors Approved by the FDA

Brand Name (Generic Drug Name)

Indications

Xospata (gilteritinib)1

Treatment of adult patients with relapsed or refractory FLT3 mutation-positive AML

Rydapt (midostaurin)2

Treatment of adult patients with newly diagnosed FLT3 mutation-positive AML

FLT3 Inhibitors in the Pipeline

Vanflyta (quizartinib)3

Treatment being evaluated for patients with relapsed/refractory FLT3-ITD AML

Crenolanib4

Treatment being evaluated for patients with newly diagnosed and relapsed/refractory FLT3 mutation-positive AML

Dovitinib5

Treatment being evaluated for patients with metastatic renal cell carcinoma

SKLB10286

Treatment being evaluated for patients with relapsed/refractory FLT3 mutation-positive AML

FLT3, fms like tyrosine kinase 3; AML, acute myeloid leukemia

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