Tucatinib Plus Trastuzumab in HER2-Positive Metastatic Colorectal Cancer: Primary Analysis of the Mountaineer Trial

10/12/2022

Thierry Andre, MD, Saint-Antoine Hospital, Paris, France, and John Strickler, MD, Duke University, Durham, NC, United States, discuss the primary analyses from the pivotal phase 2 MOUNTAINEER trial of tucatinib in combination with trastuzumab in patients with HER2-positive metastatic colorectal cancer after 2 or more lines of therapy.

The 2 oncologists review data from the MOUNTAINEER trial, which concludes that the combination of tucatinib and trastuzumab was generally well-tolerated with durable responses in patients assigned to receive the combination demonstrating a 38.1% confirmed objective response rate after a median duration of follow-up of 20.7 months. The most common (≥20%) treatment-emergent adverse events were diarrhea, fatigue, nausea and infusion-related reaction.

Dr Strickler presented these findings at the 2022 ESMO World Congress on Gastrointestinal Cancer in Barcelona, Spain.

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