Videos

BTK Inhibitor Class Switching in the First-Line Treatment of CLL and SLL: Real-World Outcomes

12/13/2022

Ryan Jacobs, MD, Levine Cancer Institute, Charlotte, NC, discusses findings from the largest real-world analysis to date of BTK inhibitor-class switching in the first-line treatment of patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

These results were presented at the 2022 American Society of Hematology (ASH) Annual Meeting and suggest that approximately 40% of patients who switch from ibrutinib to acalabrutinib experience early discontinuation. Researchers recommend careful consideration when switching within the BTK inhibitor class.

Source:

Jacobs R, Wang R, He J, et al. Real World Treatment Patterns in Patients with Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Switching from First Line Ibrutinib to Acalabrutinib. Presented at the ASH Annual Meeting & Exposition; December 10-13, 2022; New Orleans, LA, and virtual. Abstract 3578.

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