Diffuse Large B-Cell Lymphoma News

News

Polatuzumab Vedotin Plus Bendamustine and Rituximab Shows Safety in R/R DLBCL

12/02/2021

Data from a phase 2 study of polatuzumab vedotin plus bendamustine and rituximab found the combination to be efficacious and safe for patients with R/R DLBCL.

Data from a phase 2 study of...

12/02/2021

Oncology

News

BTK, STAT3 Targeting Is Safe in R/R DLBCL, But Has Limited Efficacy

11/15/2021

A phase 1b study found acalabrutinib, plus AZD9150 is safe and tolerable for patients with R/R DLBCL, but has limited efficacy; these findings were presented at the 2021 ASH Annual Meeting.

A phase 1b study found...

11/15/2021

Oncology

Conference Insider

Tafasitamab With or Without Lenalidomide and R-CHOP Tolerable for Patients With DLBCL

11/11/2021

A phase 1B study shared at the 2021 Annual ASH Meeting reported on the safety and tolerability of tafasitamab in newly diagnosed DLBCL.

A phase 1B study shared at the...

11/11/2021

Oncology

News

Glofitamab Plus R-CHOP Induces High Response Rates in NHL, DLBCL

11/08/2021

Findings from a phase 1b study found glofitamab plus R-CHOP induces high response rates with minimal CRS in patients with R/R NHL and previously untreated DLBCL. These data were presented at the 2021 ASH Annual Meeting.

Findings from a phase 1b study...

11/08/2021

Oncology

News

SNPs Do Not Impact Outcomes With Ritixumab/Obinutuzumab in FL, DLBCL

08/16/2021

SNPs have been shown to influence FcγR activity in patients with FL and DLBCL, but do not impact treatment outcomes with rituximab/obinutuzumab plus chemo, study findings suggest.

SNPs have been shown to...

08/16/2021

Oncology

News

FDA Approves Loncastuximab Tesirine-lpyl for Patients With DLBCL

04/26/2021

The FDA has approved loncastuximab tesirine-lpyl for patients with relapsed or refractory large B-cell lymphoma after 2 or more lines of systemic therapy.

The FDA has approved...

04/26/2021

Oncology

News

ROBUST Study: R-CHOP With or Without Lenalidomide in ABC-Type DLBCL

04/19/2021

Adding lenalidomide to R-CHOP has been shown to improve outcomes in patients with DLBCL and activated B-cell-like disease.

Adding lenalidomide to R-CHOP...

04/19/2021

Oncology

Conference Insider

Long-Lasting Remission With Dual Targeting CAR-T Therapy for R/R DLBCL

12/15/2020

Patients with relapsed/refractory DLBCL given AUTO3 (a CD19/22 dual targeting CAR-T therapy) plus pembrolizumab had durable responses.

Patients with...

12/15/2020

Oncology

Conference Insider

Mosunetuzumab Safe, Effective for Elderly Patients With DLBCL

12/07/2020

Single-agent mosunetuzumab shows efficacy, remarkable safety, as a chemo-free option for previously untreated elderly/unfit patients with DLBCL.

Single-agent mosunetuzumab shows...

12/07/2020

Oncology

News

FDA Approves Tafasitamab-cxix for Adults With Relapsed DLBCL

08/03/2020

The FDA has approved tafasitamab-cxix plus lenalidomide for the treatment of adults with relapsed or refractory DLBCL.

The FDA has approved...

08/03/2020

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology