CD19 News

News

Tafasitamab Plus Lenalidomide Prolongs OS in Relapsed/Refractory DLBCL: RE-MIND2

06/20/2022

Janelle Bradley

Tafasitamab plus lenalidomide prolonged OS compared to bendamustine plus rituximab or rituximab plus gemcitabine and oxaliplatin for patients with relapsed/refractory DLBCL in the RE-MIND2 study.

Tafasitamab plus lenalidomide...

06/20/2022

Oncology

News

Axicabtagene Ciloleucel Significantly Improves Outcomes Over Standard Care as Second-Line Therapy for Large B-cell Lymphoma

05/13/2022

John Otrompke

Findings from the ZUMA-7 trial suggest axicabtagene ciloleucel is an effective alternative option for the second-line treatment of relapsed or refractory large B-cell lymphoma.

Findings from the ZUMA-7 trial...

05/13/2022

Oncology

News

Pembrolizumab May Reinvigorate T-Cells in CAR-T Patients Who Relapse

04/07/2022

John Otrompke

Pembrolizumab was shown to reverse T-cell exhaustion for patients with B-cell lymphomas who did not respond well to CD19-targeted CAR T-cell therapy.

Pembrolizumab was shown to...

04/07/2022

Oncology

News

Dual CAR-T Therapy Associated With High Remission in R/R B-Cell ALL

03/09/2022

John Otrompke

Tandem CD19 and CD22 dual target CAR-T cells have been developed to achieve a CR in patients with R/R B-ALL.

Tandem CD19 and CD22 dual target...

03/09/2022

Oncology

News

Anti-CD19 CAR-T Therapy Superior to Standard of Care as Second-Line Treatment for DLBCL

03/02/2022

Results of the phase 3 ZUMA-7 trial confirm axicabtagene ciloleucel had superior EFS to second-line chemoimmunotherapy, standard of care for R/R DLBCL.

Results of the phase 3 ZUMA-7...

03/02/2022

Oncology

News

Tisagenlecleucel Shows Similar Effects to Standard Care for DLBCL

02/28/2022

In an international phase 3 trial, second-line tisagenlecleucel was not superior to salvage therapy for refractory DLBCL.

In an international phase 3...

02/28/2022

Oncology

News

Prophylactic Anakinra Prevents CRS, ICANS in Patients With LBCL Receiving CAR T-cells

02/02/2022

IL-1 receptor inhibitor anakinra demonstrates feasibility in the prevention of CRS and ICANS in patients with LBCL and MCL who receive commercial CD19 CAR T-cells.

IL-1 receptor inhibitor anakinra...

02/02/2022

Oncology

News

FDA Approves Brexucabtagene Autoleucel CAR-T Therapy for R/R B-ALL

10/04/2021

On October 1, 2021, the FDA approved brexucabtagene autoleucel for the use in the treatment of adult patients with R/R B-ALL.

On October 1, 2021, the FDA...

10/04/2021

Oncology

News

Type of Anti-CD19 CAR-T Infusion Impacts Safety, Efficacy in Patients With LBCL

10/22/2020

Clinical study findings suggest that heterogeneity of CAR T-cell infusion products affect the efficacy and toxicity of axi-cel therapy in patients with large B cell lymphoma.

Clinical study findings suggest...

10/22/2020

Oncology

News

Higher CART-19 Dosage More Effective at Inducing CR in Relapsed or Refractory CLL

09/23/2020

Findings from a study of CART-19 have established an effective dose for inducing complete responses with reduced toxicity in relapsed/refractory CLL.

Findings from a study of CART-19...

09/23/2020

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology