News

Therapeutic Monitoring of Sunitinib Shows Potential in Adults With GIST and Metastatic RCC

01/24/2020

Review findings support the use of sunitinib dose modification guided by therapeutic drug monitoring in certain patients with RCC and GIST.

Review findings support the use...

01/24/2020

Oncology

News

Study Findings Support Surveillance Imaging Past 5 Years Postsurgery in RCC

11/18/2019

Findings from a post hoc analysis support the use of surveillance imaging beyond 5 years after surgical resection in patients with intermediate- to high-risk RCC.

Findings from a post hoc...

11/18/2019

Oncology

News

Oblate-Covered Everolimus Reduces Stomatitis in Patients With Metastatic RCC

11/13/2019

Oblate-covered everolimus improved the incidence rate and reduced time to stomatitis grade ≥2 in patients with mRCC.

Oblate-covered everolimus...

11/13/2019

Oncology

News

Individualized Axitinib Dosing Feasible for Metastatic RCC

09/27/2019

A phase 2 study suggests that individualized axitinib dosing is a feasible therapy option for metastatic RCC.

A phase 2 study suggests that...

09/27/2019

Oncology

News

Nivolumab–Ipilimumab Combo Shows Long-Term Benefit in Advanced RCC

09/14/2019

Study findings show the long-term benefits of combining nivolumab therapy plus ipilimumab in treatment-naïve advanced RCC.

Study findings show the...

09/14/2019

Oncology

News

Certain Targeted Therapies Tied to Improved Survival in Non–Clear Cell RCC

05/24/2019

First-line VEGF TKIs, cytoreductive nephrectomy, and metastasectomy improved survival in patients with metastatic non–clear cell RCC in a recent study.

First-line VEGF TKIs,...

05/24/2019

Oncology

News

FDA Approves Avelumab–Axitinib Combo for First-Line Treatment of Advanced RCC

05/16/2019

The FDA has approved avelumab for use in combination with axitinib in the first-line treatment of patients with advanced RCC.

The FDA has approved avelumab...

05/16/2019

Oncology

News

FDA Approves Combination Therapy for Advanced RCC

04/22/2019

The FDA has approved the combination of pembrolizumab plus axitinib for the first-line treatment of patients with advanced RCC.

The FDA has approved the...

04/22/2019

Oncology

News

Experts Validate Classifier That Can Predict Recurrence Risk in Clear-Cell RCC

04/03/2019

Researchers have created and validated a classifier that can predict whether recurrence risk is high or low in patients with localized, clear-cell RCC.

Researchers have created and...

04/03/2019

Oncology

News

Cabozantinib Shows Promise in Treatment of Non-Clear-Cell RCC

03/07/2019

Results from a recent study suggest that cabozantinib provides significant clinical benefit to certain patients with non-clear-cell RCC.

Results from a recent study...

03/07/2019

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology