News

Conference Coverage

Recent Breakthroughs in the Mantle Cell Lymphoma Treatment Landscape

01/08/2024

Featuring Bijal D. Shah, MD

Bijal D. Shah, MD, shares the breakthroughs in the mantle cell lymphoma treatment landscape that he found most promising at the 65th American Society of Hematology (ASH) Annual Meeting.

Bijal D. Shah, MD, shares the...

01/08/2024

Oncology

Conference Coverage

Recent Breakthroughs in the Mantle Cell Lymphoma Treatment Landscape

01/08/2024

Featuring Bijal D. Shah, MD

Bijal D. Shah, MD, shares the breakthroughs in the mantle cell lymphoma treatment landscape that he found most promising at the 65th American Society of Hematology (ASH) Annual Meeting.

Bijal D. Shah, MD, shares the...

01/08/2024

Oncology

Conference Coverage

Bispecific Lentiviral Anti-CD20/Anti-CD19 CAR T-Cells for R/R MCL

12/21/2023

Featuring Nirav Shah, MD

During the 2023 ASH Annual Meeting in San Diego, Nirav N Shah, MD, discussed the efficacy of dual-targeted lentiviral anti-CD20/anti-CD19 (LV20.19) CAR T-cells with an adaptive manufacturing process among patients with relapsed/refractory...

During the 2023 ASH Annual...

12/21/2023

Oncology

Conference Coverage

Bendamustine, Rituximab, and Venetoclax Shows Promise Among Previously Untreated Older Patients With MCL

12/21/2023

Featuring Craig A Portell, MD

At the 65th ASH Annual Meeting, Craig A Portell, MD, assessed the potential benefit of bendamustine, rituximab, and venetoclax as an initial treatment among older patients with mantle cell lymphoma, noting that results and safety precautions...

At the 65th ASH Annual Meeting,...

12/21/2023

Oncology

Conference Coverage

Real-World Value of Brexucabtagene Autoleucel for Patients With R/R MCL Including High-Risk Features

12/20/2023

Featuring Swetha Kambhampati, MD

Featuring Swetha Kambhampati, MD ...

At the 65th ASH Annual Meeting, Swetha Kambhampati, MD, shares data on the real-world outcomes of brexucabtagene autoleucel treatment for patients with R/R mantle cell lymphoma, including high-risk subgroups.

At the 65th ASH Annual Meeting,...

12/20/2023

Oncology

Conference Coverage

Assessing the Optimal Ki-67 Cut-Off for Outcome Prediction Among Patients With Newly Diagnosed Mantle Cell Lymphoma

12/10/2023

Featuring Narendranath Epperla, MD, MS

Featuring Narendranath Epperla, MD, M...

At the 65th ASH Annual Meeting, Narendranath Epperla, MD, MS, shared insights on an optimal Ki-67 cut-off for patients with newly diagnosed mantle cell lymphoma, which was found to be prognostic for progression-free survival, but not overall...

At the 65th ASH Annual Meeting,...

12/10/2023

Oncology

News

Rituximab, Lenalidomide, and Ibrutinib Regimen Exhibits Safe and Effective Outcomes Among Patients With R/R MCL

11/28/2023

Jordan Kadish

The R21 regimen, consisting of rituximab, lenalidomide, and ibrutinib, exhibited safe and effective outcomes among patients with R/R mantle cell lymphoma, including those with high-risk features.

The R21 regimen, consisting of...

11/28/2023

Oncology

News

Brexucabtagene Autoleucel vs Standard-Of-Care Treatment for Patients With R/R MCL

11/28/2023

Jordan Kadish

According to a comparative analysis of the SCHOLAR-2 and ZUMA-2 trials, brexucabtagene autoleucel showed significant survival benefits compared to the standard-of-care treatment for patients with R/R mantle cell lymphoma after covalent BTK...

According to a comparative...

11/28/2023

Oncology

News

Bridging and Salvage Radiotherapy Significantly Improved In-Field Control Among Patients With R/R MCL

11/06/2023

Jordan Kadish

The use of radiotherapy as a bridging and salvage approach significantly improved in-field control outcomes and safety in the peri-CAR T setting among patients with R/R mantle cell lymphoma.

The use of radiotherapy as a...

11/06/2023

Oncology

News

Anti-CD19 CAR T-Cell Therapy Demonstrates Feasibility Among Patients With MCL With Secondary CNS Involvement

11/06/2023

Jordan Kadish

Anti-CD19 chimeric antigen receptor T-cell therapy was demonstrated to be feasible among patients with mantle cell lymphoma with secondary central nervous system involvement.

Anti-CD19 chimeric antigen...

11/06/2023

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology