News

Encorafenib Plus Binimetinib Exhibited Clinical Efficacy and Safety Among Patients With BRAFV600E-Mutant Metastatic NSCLC

07/10/2023

Stephanie Holland ;

Data from a phase 2 trial show that encorafenib plus binimetinib exhibited meaningful clinical efficacy and safety in BRAFV600E-mutant metastatic NSCLC.

Data from a phase 2 trial show...

07/10/2023

Oncology

News

No Difference in Overall Survival Between Immunotherapy Treatment Lengths Among Patients With Advanced NSCLC

07/10/2023

Amber Denham ;

Patients with non–small cell lung cancer who are progression-free on immunotherapy may be able to stop therapy at 2 years with no effect on overall survival.

Patients with non–small cell...

07/10/2023

Oncology

News

Low-Dose Spiral Computed Tomography Screening Aids in Reduction of Lung Cancer Mortality

02/22/2023

Derek Cowsert ;

In a prospective study, one-off low-dose spiral computed tomography screening demonstrated accuracy in detecting positive nodules and efficacy in reducing lung cancer mortality.

In a prospective study, one-off...

02/22/2023

Oncology

News

Optimal Surgery and Treatment Options for Stage 1 Lung Adenocarcinoma/Tumors Spread Through Air Spaces

02/22/2023

Derek Cowsert ;

A study found no difference in survival outcomes between sublobar resection and lobectomy among patients stage 1 lung adenocarcinoma/tumors spread through air spaces.

A study found no difference in...

02/22/2023

Oncology

News

High Tumor Mutational Burden Associated With Improved Progression-Free Survival Among Patients With NSCLC

02/16/2023

Derek Cowsert ;

A study found high tumor mutational burden to be associated with improved local-regional control and progression-free survival among patients with non-small cell lung cancer treated with chemoradiation and durvalumab.

A study found high tumor...

02/16/2023

Oncology

News

Early Progression Patterns of Lung Squamous Cell Carcinoma on Computed Tomography Images

02/07/2023

Derek Cowsert ;

Findings from a study reveal lung squamous cell carcinoma initiated with a variety of image patterns on computed tomography.

Findings from a study reveal...

02/07/2023

Oncology

News

Impact of Age on Quality of Life After Immune Checkpoint Inhibitor Treatment for Patients With Lung Cancer

02/07/2023

Derek Cowsert ;

A study found old age to be a significant risk factor for lower quality of life scores for patients with lung cancer who received immune checkpoint inhibitor treatment.

A study found old age to be a...

02/07/2023

Oncology

News

FDA Approves Pembrolizumab as Adjuvant Treatment for Non-Small Cell Lung Cancer

01/27/2023

On January 26, 2023, the FDA granted approval to pembrolizumab as an adjuvant treatment for patients with non-small cell lung cancer.

On January 26, 2023, the FDA...

01/27/2023

Oncology

News

Lorlatinib Significantly Improves Survival vs Crizotinib in Patients With ALK-Positive Advanced NSCLC Regardless of Brain Metastases

07/12/2022

Derek Cowsert ;

Lorlatinib was associated with improved PFS vs crizotinib among patients with ALK-positive advanced NSCLC, with or without brain metastases, according to findings from the phase 3 CROWN study.

Lorlatinib was associated with...

07/12/2022

Oncology

News

Amivantamab Associated With Improved Outcomes vs Real-World Therapies in EGFR-Mutated NSCLC

07/07/2022

Janelle Bradley ;

Among patients with EGFR-mutated advanced NSCLC whose disease progressed after platinum-based chemotherapy, treatment with amivantamab is associated with improved outcomes vs real-world therapies, according to a recent study.

Among patients with EGFR-mutated...

07/07/2022

Oncology

Recent News

News

Intraoperative Radiation Therapy May Improve Survival For Certain Patients With Recurrent Cervical or Endometrial Cancer

11/14/2024

Allison Casey ;

According to a retrospective study, there was an appreciable survival gain for well-selected patients with recurrent or persistent endometrial or cervical cancer who receive intraoperative radiation therapy.

According to a retrospective...

11/14/2024

Oncology

News

Amrubicin Plus Irinotecan Demonstrates Promising Efficacy, Safety for Chemotherapy-Naïve Patients With Extensive-Disease Small Cell Lung Cancer

11/14/2024

Stephanie Holland ;

According to results from the phase 2 LC 08-01 trial, amrubicin plus irinotecan demonstrated promising efficacy and safety among chemotherapy-naïve patients with extensive-disease small cell lung cancer.

According to results from the...

11/14/2024

Oncology

News

Addition of Bempegaldesleukin to Nivolumab Does Not Benefit Cisplatin-Ineligible Patients With First-Line Advanced Urothelial Carcinoma

11/13/2024

Stephanie Holland ;

Results from the phase 2 PIVOT-10 trial demonstrated that the addition of bempegaldesleukin to first-line nivolumab did not improve outcomes for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.

Results from the phase 2...

11/13/2024

Oncology

News

Mirdametinib for Adult and Pediatric Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

11/12/2024

Allison Casey ;

According to a phase 2b trial, mirdametinib demonstrated significant confirmed objective response rates with deep and durable reductions of volume of target plexiform neurofibromas and clinically meaningful improvements to health-related...

According to a phase 2b trial,...

11/12/2024

Oncology

News

Epirubicin Plus Cyclophosphamide and Docetaxel Reduces Long-Term Risk of Recurrence for Patients With TOP2A Normal Early Breast Cancer

11/12/2024

Stephanie Holland ;

According to final results from the DBCG 07-READ trial, the addition of epirubicin to cyclophosphamide and docetaxel reduced long-term risk of breast cancer recurrence among patients with TOP2A normal early breast cancer.

According to final results from...

11/12/2024

Oncology

News

Pembrolizumab Plus Chemotherapy For Patients With High-Risk Endometrial Cancer

11/11/2024

Allison Casey ;

According to results from a phase 3 trial, pembrolizumab plus chemotherapy did not improve DFS among patients with high-risk endometrial cancer. However, there may be a benefit among patients with mismatch report-deficient disease.

According to results from a...

11/11/2024

Oncology

FDA Approval

FDA Grants Approval to Obecabtagene Autoleucel for R/R B-Cell Precursor Acute Lymphoblastic Leukemia

11/08/2024

On November 8, 2024, the FDA approved CD19-directed genetically modified autologous T cell immunotherapy obecabtagene autoleucel for the treatment of patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.

On November 8, 2024, the FDA...

11/08/2024

Oncology

News

Naporafenib in Combination With Rineterkib or Tremetinib for KRAS- or BRAF-Mutant Non-Small Cell Lung Cancer

11/07/2024

Allison Casey ;

While naporafenib plus rineterkib and naporafenib plus trametinib both had acceptable safety profiles, antitumor activity was limited among patients with KRAS-/BRAF-mutant non-small cell lung cancer.

While naporafenib plus...

11/07/2024

Oncology

News

Addition of Concurrent Thoracic Radiotherapy to First-Line TKI Therapy Improves Survival for Patients With EGFR-Mutated Non-Small Cell Lung Cancer

11/06/2024

Stephanie Holland ;

According to results from a phase 3 trial, the addition of concurrent thoracic radiotherapy to first-line icotinib improved survival among patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer.

According to results from a...

11/06/2024

Oncology

News

Ipilimumab After PD-1 Inhibition Failure Among Patients With Metastatic Melanoma

11/05/2024

Allison Casey ;

A single-center real-world study found the use of ipilimumab in the second-line was an effective therapy for patients with metastatic BRAF/NRAS-wildtype metastatic melanoma without brain metastases.

A single-center real-world study...

11/05/2024

Oncology