News

Upper-Neck vs Whole-Neck Irradiation in Patients With Nasopharyngeal Carcinoma

05/02/2022

John Otrompke

Elective upper-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma demonstrated non–inferiority to whole-neck irradiation in a phase 3 trial.

Elective upper-neck irradiation...

05/02/2022

Oncology

News

Induction With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil for Nasopharyngeal Carcinoma

04/14/2022

John Otrompke

Study findings suggest induction therapy with paclitaxel, cisplatin, and capecitabine is associated with a significant improvement in failure-free survival compared to cisplatin and fluorouracil in patients with late-stage nasopharyngeal...

Study findings suggest induction...

04/14/2022

Oncology

News

Concurrent Chemoradiotherapy With S-1 Superior to RT Alone in Esophageal Cancer

08/31/2021

Concurrent chemoradiotherapy with S-1 demonstrated efficacy, tolerability over radiotherapy alone in older patients with esophageal cancer.

Concurrent chemoradiotherapy...

08/31/2021

Oncology

News

FDA Approves Pralsetinib for RET-Altered Thyroid Cancers

12/02/2020

The FDA has approved pralsetinib for the treatment of adult and pediatric patients with RET-mutated thyroid cancer.

The FDA has approved pralsetinib...

12/02/2020

Oncology

News

NSAIDs During CRT Tied to Improved OS in Patients With HNSCC

08/05/2020

Findings from a cohort study suggest that patients with HNSCC who take NSAIDs during chemoradiation may achieve an OS advantage.

Findings from a cohort study...

08/05/2020

Oncology

News

Adding Pembrolizumab to Chemoradiotherapy Safe for Locally Advanced HNSCC

07/20/2020

Study findings show that combining pembrolizumab with weekly cisplatin-based chemoradiotherapy is safe for patients with locally advanced HNSCC.

Study findings show that...

07/20/2020

Oncology

News

Lenvatinib Active in Unresectable, Metastatic Thymic Carcinoma

07/17/2020

Lenvatinib demonstrated activity and manageable safety in patients with advanced thymic carcinoma, study findings show.

Lenvatinib demonstrated activity...

07/17/2020

Oncology

News

Combo Regimen Shows Significant Antitumor Activity in Refractory/Relapsed Neuroblastoma

07/02/2020

In a study of patients with relapsed or refractory neuroblastoma, combo therapy with irinotecan, temozolomide, dintuximab, and GM-CSF yielded significant antitumor activity.

In a study of patients with...

07/02/2020

Oncology

News

Spartalizumab Shows Promise in Patients With Advanced/Metastatic Anaplastic Thyroid Cancer

06/22/2020

Spartalizumab showed promising clinical activity and a good safety profile in patients with aggressive anaplastic thyroid carcinoma, according to phase 1/2 study findings.

Spartalizumab showed promising...

06/22/2020

Oncology

News

Possible Link Found Between Age and Papillary Thyroid Cancer Progression in Adults Being Surveilled

06/12/2020

Study findings suggest there may be an association between advancing age and reduced risk for papillary thyroid tumor enlargement being actively monitored.

Study findings suggest there may...

06/12/2020

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology