News

Lenvatinib–Pembrolizumab Shows Potential in Advanced Endometrial Cancer

03/24/2020

Lenvatinib plus pembrolizumab has shown promise in patients with advanced endometrial cancer, regardless of tumor MSI status.

Lenvatinib plus pembrolizumab...

03/24/2020

Oncology

News

FDA Approves Pembrolizumab–Lenvatinib Combo for Endometrial Carcinoma

09/17/2019

The FDA granted accelerated approval to the combination of pembrolizumab and lenvatinib for the treatment of advanced endometrial carcinoma that is not MSI-H or dMMR, and disease that progresses following prior systemic therapy.

The FDA granted accelerated...

09/17/2019

Oncology

News

Adjuvant Chemoradiotherapy Improves OS vs Radiotherapy in High-Risk Endometrial Cancer

08/29/2019

Combining adjuvant chemo with radiotherapy significantly improved OS and RFS versus radiotherapy alone in women with high-risk endometrial cancer.

Combining adjuvant chemo with...

08/29/2019

Oncology

News

Adjuvant Pelvic Radiotherapy Appropriate Treatment for Early-Stage Endometrial Cancers

05/06/2019

A recent study did not demonstrate the superiority of vaginal cuff brachytherapy plus chemotherapy over pelvic radiation therapy in patients with early-stage endometrial cancer.

A recent study did not...

05/06/2019

Oncology

News

Lenvatinib–Pembrolizumab Combo Promising for Treatment of Endometrial Cancer

04/10/2019

Results from a phase 2 trial suggest that lenvatinib plus pembrolizumab is a novel combination therapy option for patients with advanced recurrent endometrial cancer.

Results from a phase 2 trial...

04/10/2019

Oncology

News

Adjuvant Taxane Plus Platinum Can Replace Doxorubicin Plus Cisplatin in Endometrial Cancer

04/08/2019

Regimens combining taxane and platinum are feasible alternatives to doxorubicin plus cisplatin in adjuvant chemotherapy for patients with endometrial cancer.

Regimens combining taxane and...

04/08/2019

Oncology

News

Minimally Invasive Endometrial Surgery Leads to Fewer Severe Complications

03/01/2019

Implementation of minimally invasive robotic surgery for early stage endometrial cancer has been associated with a reduced risk for severe complications.

Implementation of minimally...

03/01/2019

Oncology

News

Adjuvant Chemoradiation May Be Considered for High-Risk Endometrial Cancer

03/02/2018

Adjuvant chemotherapy given during and after pelvic radiation for high-risk endometrial cancer improves failure-free, but not overall, survival at five years and may be discussed as an alternative to radiation alone.

Adjuvant chemotherapy given...

03/02/2018

Oncology

Recent News

News

Osimertinib Lacks Activity in Neoadjuvant Setting for Early-Stage Non-Small Cell Lung Cancer With EGFR Mutation

08/08/2024

Stephanie Holland ;

Results from a phase 2 study demonstrated that neoadjuvant osimertinib did not improve the major pathological response rate among patients with early-stage non-small cell lung cancer harboring an EGFR mutation.

Results from a phase 2 study...

08/08/2024

Oncology

FDA Approval

FDA Approves Denileukin Diftitox for Patients With R/R Cutaneous T-Cell Lymphoma

08/08/2024

Amber Denham ;

The US Food and Drug Administration approved novel immunotherapy denileukin diftitox-cxdl for the treatment of patients with relapsed/refractory cutaneous T-cell lymphoma after at least 1 prior systemic therapy.

The US Food and Drug...

08/08/2024

Oncology

News

Tailored Dose-Dense Chemotherapy Improved Survival Outcomes Among Patients With High-Risk Early Breast Cancer

08/07/2024

Stephanie Holland ;

According to results from the phase 3 PANTHER trial, tailored and dose-dense chemotherapy in the adjuvant setting improved survival outcomes compared to standard chemotherapy among patients with high-risk early breast cancer.

According to results from the...

08/07/2024

Oncology

News

Frontline Treatment Management for Patients With FL Reduces Risk of High-Grade Transformation to DLBCL

08/07/2024

Amber Denham ;

A recent study demonstrated that frontline treatment management reduced the risk of high-grade transformation to diffuse large B-cell lymphoma among patients with follicular lymphoma, but not among patients with marginal zone lymphoma.

A recent study demonstrated that...

08/07/2024

Oncology

News

Optimal Sotorasib Dose for Patients With KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer

08/07/2024

Stephanie Holland ;

Results from a phase 2 study found that 960 mg of sotorasib is preferable to 240 mg among patients with previously treated KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer.

Results from a phase 2 study...

08/07/2024

Oncology

FDA Approval

FDA Approves Vorasidenib for Patients With IDH1/IDH2-Mutated Grade 2 Astrocytoma or Oligodendroglioma

08/06/2024

Stephanie Holland ;

Based on results from the INDIGO trial, the FDA has approved vorasidenib for adult and pediatric patients 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery.

Based on results from the INDIGO...

08/06/2024

Oncology

FDA Approval

FDA Approves Afamitresgene Autoleucel for Certain Unresectable or Metastatic Synovial Sarcoma

08/02/2024

Allison Casey ;

On August 2, 2024, the US Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel for the treatment of adult patients with certain unresectable or metastatic synovial sarcomas who had received prior...

On August 2, 2024, the US Food...

08/02/2024

Oncology

FDA Approval

FDA Approves Dostarlimab Plus Chemotherapy for Patients With Primary Advanced or Recurrent Endometrial Cancer

08/01/2024

Allison Casey ;

The FDA approved dostarlimab plus carboplatin and paclitaxel, followed by single-agent dostarlimab for patients with primary advanced or recurrent endometrial cancer.

The FDA approved dostarlimab...

08/01/2024

Oncology

News

Iadademstat and Azacitidine Combination Therapy Demonstrates Manageable Safety, Promising Efficacy for Patients With Newly Diagnosed AML

08/01/2024

Amber Denham ;

The first-line combination of iadademstat and azacitidine demonstrates a manageable safety profile and promising results among patients with acute myeloid leukemia, according to phase 2 results from the ALICE trial.

The first-line combination of...

08/01/2024

Oncology

News

Effect of Food on Selumetinib Dosing for Adolescent Patients With Neurofibromatosis Type 1 With Plexiform Neurofibromas

08/01/2024

Allison Casey ;

In the phase 1 trial, the addition of a low-fat meal with doses of selumetinib did not significantly impact selumetinib exposure or gastrointestinal toxicities among adolescent patients with neurofibromatosis type 1 with plexiform...

In the phase 1 trial, the...

08/01/2024

Oncology