Conference Coverage

Rezatapopt Demonstrated Promising Efficacy Among Heavily Pre-Treated Patients With Advanced Ovarian Cancer

Featuring Alison Schram, MD

04/01/2024

Alison Schram, MD, Memorial Sloan Kettering Cancer Center, New York, New York, discussed results from the PYNNACLE study, evaluating rezatapopt (PC14586) the first-in-class selective p53 reactivator specific to TP53-Y220C, as presented at the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting.

Results found rezatapopt demonstrated promising clinical efficacy among heavily pre-treated patients with advanced ovarian cancer harboring a TP53 Y220C mutation, with a favorable safety profile.

Source:

Schram A, Shapiro GI, Thompson JA, et al. Phase I analysis from the PYNNACLE phase I/II study of PC14586 in the subgroup of patients with advanced ovarian cancer harboring a TP53 Y220C mutation. Presented at the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting; March 16-18, 2024. San Diego, California

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Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of Oncology Learning Network or HMP Global, their employees, and affiliates.

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