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From 2012 to 2018: Seven years' analysis of NETs, the experience of the Mohamed VI University Hospital center in Marrakech
Background
Neuroendocrine tumors are a specific tumor entity because of its rarity (they represent 1% of all digestive tumors) and its heterogeneity both clinical and biological. The purpose of our work was to describe the diagnostic and therapeutic management of digestive neuroendocrine tumors at the hematology oncology center of Mohamed VI University Hospital of Marrakech, through a serie of 53 cases.
Methods
This is a retrospective study of the files of patients followed in the medical oncology and visceral surgery departments of CHU Mohamed VI in Marrakech. This study was spread over a period of 7 years from January 2012 to December 2018.
Results
Our patients were divided into 32 women (60%), and 21 men (40%) with a sex ratio of 0.65. The average age of discovery was 54.12 (16-88). The age group> 60 is the most affected. The majority of cases (58%) corresponded to well-differentiated NETs according to the OMS 2010 classification, with poorly differentiated CNEs accounting for 38%. The majority of patients were found to be in an advanced stage (51%), the extension assessment found hepatic metastases in 39.6% and loco-regional in 39.6% of patients. Pancreatic localization was the most common (30.2%), followed by hail (20.7%); Stomach (7.5%), ileocecal location (5.6%), rectal 5.6%. 50.9% of patients underwent surgical excision of their primary tumors and 5.7% palliative surgery. Metastasectomy was performed in a single patient with secondary hepatic localization.
Conclusions
However chemotherapy was used as a palliative treatment in 10 cases, as an adjuvant treatment in a single case and as a neoadjuvant treatment in 5 cases. Treatment with targeted therapies was administered in 2 patients, somatostatin analogues in 3 patients. The comparison of our results with those of the literature led us to conclude that our patients were treated at an advanced stage of the disease. So it is very necessary to improve our diagnostic and therapeutic approach to digestive NETs.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosures
All authors have declared no conflicts of interest.
