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Study Identifies Factors Associated With GIST Recurrence and Metastasis
Primary site of tumors, tumor rupture, tumor diameter, risk grade, and mitotic figures were identified as factors closely associated with postoperative recurrence or metastasis in patients with gastrointestinal stromal tumors (GIST), according to a retrospective analysis.
The study enrolled 422 patients with GIST who had received surgery at the First Affiliated Hospital of Wenzhou Medical University between January 2018 and December 2019. Follow up continued until March 31, 2022. Through statistical analyses, the relationship between clinicopathological characteristics and recurrence or metastasis was observed.
Tumor rupture (P = .040), tumor location (P <.001), tumor diameter particularly > 10 cm (P = .016), mitotic figures ≥ 1o per 50 HPFs (P >.001), and higher risk tumor classification (P <.009) all affected the prognosis of patients with GIST.
The study authors stated that “individualized diagnosis and treatment for GIST should be performed based on clinicopathological characteristics and prediction of the risk of postoperative recurrence and metastasis.”
Source:
Chen S, Sang K, Chen W, et al. Risk factors and prognostic analysis of gastrointestinal stromal tumor recurrence-metastasis. Comput Math Methods Med. Published online July 18, 2022. doi:10.1155/2022/1127146
