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Preoperative Controlling Nutritional Status Score Predicts Recurrence in Patients With Resected GIST
According to study results, an elevated preoperative controlling nutritional status (CONUT) score was a predictor of recurrence in patients with resected gastrointestinal stromal tumors (GISTs). The CONUT score is a laboratory-derived immuno-nutritional screening tool based on serum albumin, total cholesterol, and lymphocyte count.
The study included 455 patients with completely resected GISTs who did not receive imatinib adjuvant therapy. The patients were classified into 3 groups, based on CONUT score: normal nutrition or a CONUT score of 0 to 1 (n = 219, 48.1%), mild malnutrition or a CONUT score of 2 to 4 (n = 196, 43.1%), and moderate-severe malnutrition or a CONUT score of ≥5 (n = 40, 8.8%). The primary outcome was recurrence-free survival.
The median follow-up time was 132 months. Recurrence or metastasis was reported in 92 (20.2%) patients. Independent prognostic factors for shorter recurrence-free survival were nongastric primary tumor site, large tumor size, high mitotic index, tumor rupture, and a high CONUT score, when using multivariate analysis (P < .05).
Study authors concluded, “The clinical application of the CONUT score is simple and feasible, and might contribute to the individualized treatment of GIST patients.”
Source:
Yang W, Shou C, Yu J, et al. Elevated preoperative controlling nutritional status (CONUT) scores as a predictor of postoperative recurrence in gastrointestinal stromal tumors. J Surg Oncol. Published online August 1, 2022. doi:10.1002/jso.27042
