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Controlling Nutritional Status Score Shows Prognostic Value Among Older Patients With DLBCL
A recent study demonstrated that the controlling nutritional status (CONUT) score, which is a simple nutritional index, showed prognostic value for predicting outcomes among older patients with diffuse large B-cell lymphoma (DLBCL).
This retrospective, cohort study evaluated the prognostic impact among 203 older patients (≥65 years of age) with DLBCL who were treated with R-CHOP regimens. The score was an independent prognostic factor for overall survival (hazard ratio 1.11, 95% confidence interval [CI] 1.01 to 1.21, P = 0.032) in a multivariable Cox proportional hazards model.
On receiver-operating characteristic analysis, the optimal cutoff value was 3. The CONUT score (≥3 or <3) effectively stratified older DLBCL patients, regardless of the International Prognostic Index (P = 0.71 for interaction). Furthermore, the CONUT score independently affected initial dose intensity (odds ratio 0.84, 95% CI, 0.73 to 0.95, P = 0.008), which likely reflected the patients’ status at diagnosis and affected any dose adjustments.
Overall, investigators concluded that this simple nutritional index score can be predictive of a poorer prognosis among older patients with DLBCL.
Source:
Kaneda Y, Kanemura N, Nakamura N, et al. The pretreatment controlling nutritional status score is an independent prognostic factor in elderly patients with diffuse large b-cell lymphoma. Leukemia & Lymphoma. Published online December 20, 2023. doi:10.1080/10428194.2023.2295787
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