The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to https://www.galdermausa.com/Our-Commitment/PreBoard-Webinar.aspx.
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
a) Keratoacanthoma
b) Wart
c) Hypertrophic discoid lupus erythematosus
d) Squamous cell carcinoma
e) Lupus profundus
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
a) Vesicles never occur
b) It is associated with an increase in fetal mortality
c) It usually spares the umbilicus
d) It usually spares abdominal striae
e) It usually recurs in subsequent pregnancies
To learn the answers, go to page 2
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BOARD REVIEW ANSWERS
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
d) Squamous cell carcinoma
There are an increasing number of reports of squamous cell carcinoma developing in sites of chronic inflammation and scarring in patients with discoid lupus erythematosus. The incidence is unknown; however, the link between discoid lupus erythematosus and squamous cell carcinoma suggests a cause and effect relationship. These lesions should not be mistaken for hypertrophic discoid lupus erythematosus or ostraceous or verrucous cutaneous lupus erythematosus.
Reference
Keith WD, Kelly AP, Sumrall AJ, Chabra A. Squamous cell carcinoma arising in lesions of discoid lupus erythematosus in black persons. Arch Dermatol. 1980;116(3):315-317.
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
c) It usually spares the umbilicus
The eruption is polymorphic eruption of pregnancy or pruritic urticarial papules and plaques of pregnancy. Characterized clinically by onset usually in the last 5 weeks of pregnancy, with a higher incidence in first pregnancies. The lesions include urticarial papules, plaques, target lesions, polycyclic wheals, and small vesicles. The lesions usually begin on the abdomen, often in striae, but usually spare the umbilicus. The eruption may become generalized but usually spares the palms and soles. Mucous membranes are not involved. It usually subsides in the second week after delivery. Patients are systemically well and the fetus is unaffected. The histology is characterized by dermal edema and a perivascular infiltrate of mononuclear cells and eosinophils in the upper dermis. Spongiosis may be present. Direct immunofluorescence studies are always negative. Treatment is symptomatic.
References
Taylor D, Pappo E, Aronson IK. Polymorphic eruption of pregnancy. Clin Dermatol. 2016 May-Jun;34(3):383-91.
Brandão P, Sousa-Faria B, Marinho C, Vieira-Enes P, Melo A, Mota L. Polymorphic eruption of pregnancy: review of literature. J Obstet Gynaecol. 2017 Feb;37(2):137-140.
Jo-David Fine, MD, MPH, FRCP, is board certified in internal medicine, dermatology, and diagnostic and laboratory immunodermatology. Dr Fine is currently professor of medicine (dermatology) and pediatrics at Vanderbilt University School of Medicine in Nashville, TN.
Ron J. Feldman, MD, PhD, is assistant professor in the department of dermatology at Emory University School of Medicine in Atlanta, GA.
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to https://www.galdermausa.com/Our-Commitment/PreBoard-Webinar.aspx.
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
a) Keratoacanthoma
b) Wart
c) Hypertrophic discoid lupus erythematosus
d) Squamous cell carcinoma
e) Lupus profundus
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
a) Vesicles never occur
b) It is associated with an increase in fetal mortality
c) It usually spares the umbilicus
d) It usually spares abdominal striae
e) It usually recurs in subsequent pregnancies
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
d) Squamous cell carcinoma
There are an increasing number of reports of squamous cell carcinoma developing in sites of chronic inflammation and scarring in patients with discoid lupus erythematosus. The incidence is unknown; however, the link between discoid lupus erythematosus and squamous cell carcinoma suggests a cause and effect relationship. These lesions should not be mistaken for hypertrophic discoid lupus erythematosus or ostraceous or verrucous cutaneous lupus erythematosus.
Reference
Keith WD, Kelly AP, Sumrall AJ, Chabra A. Squamous cell carcinoma arising in lesions of discoid lupus erythematosus in black persons. Arch Dermatol. 1980;116(3):315-317.
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
c) It usually spares the umbilicus
The eruption is polymorphic eruption of pregnancy or pruritic urticarial papules and plaques of pregnancy. Characterized clinically by onset usually in the last 5 weeks of pregnancy, with a higher incidence in first pregnancies. The lesions include urticarial papules, plaques, target lesions, polycyclic wheals, and small vesicles. The lesions usually begin on the abdomen, often in striae, but usually spare the umbilicus. The eruption may become generalized but usually spares the palms and soles. Mucous membranes are not involved. It usually subsides in the second week after delivery. Patients are systemically well and the fetus is unaffected. The histology is characterized by dermal edema and a perivascular infiltrate of mononuclear cells and eosinophils in the upper dermis. Spongiosis may be present. Direct immunofluorescence studies are always negative. Treatment is symptomatic.
References
Taylor D, Pappo E, Aronson IK. Polymorphic eruption of pregnancy. Clin Dermatol. 2016 May-Jun;34(3):383-91.
Brandão P, Sousa-Faria B, Marinho C, Vieira-Enes P, Melo A, Mota L. Polymorphic eruption of pregnancy: review of literature. J Obstet Gynaecol. 2017 Feb;37(2):137-140.
Jo-David Fine, MD, MPH, FRCP, is board certified in internal medicine, dermatology, and diagnostic and laboratory immunodermatology. Dr Fine is currently professor of medicine (dermatology) and pediatrics at Vanderbilt University School of Medicine in Nashville, TN.
Ron J. Feldman, MD, PhD, is assistant professor in the department of dermatology at Emory University School of Medicine in Atlanta, GA.
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to https://www.galdermausa.com/Our-Commitment/PreBoard-Webinar.aspx.
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
a) Keratoacanthoma
b) Wart
c) Hypertrophic discoid lupus erythematosus
d) Squamous cell carcinoma
e) Lupus profundus
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
a) Vesicles never occur
b) It is associated with an increase in fetal mortality
c) It usually spares the umbilicus
d) It usually spares abdominal striae
e) It usually recurs in subsequent pregnancies
,
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to https://www.galdermausa.com/Our-Commitment/PreBoard-Webinar.aspx.
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
a) Keratoacanthoma
b) Wart
c) Hypertrophic discoid lupus erythematosus
d) Squamous cell carcinoma
e) Lupus profundus
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
a) Vesicles never occur
b) It is associated with an increase in fetal mortality
c) It usually spares the umbilicus
d) It usually spares abdominal striae
e) It usually recurs in subsequent pregnancies
To learn the answers, go to page 2
{{pagebreak}}
BOARD REVIEW ANSWERS
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
d) Squamous cell carcinoma
There are an increasing number of reports of squamous cell carcinoma developing in sites of chronic inflammation and scarring in patients with discoid lupus erythematosus. The incidence is unknown; however, the link between discoid lupus erythematosus and squamous cell carcinoma suggests a cause and effect relationship. These lesions should not be mistaken for hypertrophic discoid lupus erythematosus or ostraceous or verrucous cutaneous lupus erythematosus.
Reference
Keith WD, Kelly AP, Sumrall AJ, Chabra A. Squamous cell carcinoma arising in lesions of discoid lupus erythematosus in black persons. Arch Dermatol. 1980;116(3):315-317.
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
c) It usually spares the umbilicus
The eruption is polymorphic eruption of pregnancy or pruritic urticarial papules and plaques of pregnancy. Characterized clinically by onset usually in the last 5 weeks of pregnancy, with a higher incidence in first pregnancies. The lesions include urticarial papules, plaques, target lesions, polycyclic wheals, and small vesicles. The lesions usually begin on the abdomen, often in striae, but usually spare the umbilicus. The eruption may become generalized but usually spares the palms and soles. Mucous membranes are not involved. It usually subsides in the second week after delivery. Patients are systemically well and the fetus is unaffected. The histology is characterized by dermal edema and a perivascular infiltrate of mononuclear cells and eosinophils in the upper dermis. Spongiosis may be present. Direct immunofluorescence studies are always negative. Treatment is symptomatic.
References
Taylor D, Pappo E, Aronson IK. Polymorphic eruption of pregnancy. Clin Dermatol. 2016 May-Jun;34(3):383-91.
Brandão P, Sousa-Faria B, Marinho C, Vieira-Enes P, Melo A, Mota L. Polymorphic eruption of pregnancy: review of literature. J Obstet Gynaecol. 2017 Feb;37(2):137-140.
Jo-David Fine, MD, MPH, FRCP, is board certified in internal medicine, dermatology, and diagnostic and laboratory immunodermatology. Dr Fine is currently professor of medicine (dermatology) and pediatrics at Vanderbilt University School of Medicine in Nashville, TN.
Ron J. Feldman, MD, PhD, is assistant professor in the department of dermatology at Emory University School of Medicine in Atlanta, GA.
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to https://www.galdermausa.com/Our-Commitment/PreBoard-Webinar.aspx.
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
a) Keratoacanthoma
b) Wart
c) Hypertrophic discoid lupus erythematosus
d) Squamous cell carcinoma
e) Lupus profundus
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
a) Vesicles never occur
b) It is associated with an increase in fetal mortality
c) It usually spares the umbilicus
d) It usually spares abdominal striae
e) It usually recurs in subsequent pregnancies
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
d) Squamous cell carcinoma
There are an increasing number of reports of squamous cell carcinoma developing in sites of chronic inflammation and scarring in patients with discoid lupus erythematosus. The incidence is unknown; however, the link between discoid lupus erythematosus and squamous cell carcinoma suggests a cause and effect relationship. These lesions should not be mistaken for hypertrophic discoid lupus erythematosus or ostraceous or verrucous cutaneous lupus erythematosus.
Reference
Keith WD, Kelly AP, Sumrall AJ, Chabra A. Squamous cell carcinoma arising in lesions of discoid lupus erythematosus in black persons. Arch Dermatol. 1980;116(3):315-317.
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
c) It usually spares the umbilicus
The eruption is polymorphic eruption of pregnancy or pruritic urticarial papules and plaques of pregnancy. Characterized clinically by onset usually in the last 5 weeks of pregnancy, with a higher incidence in first pregnancies. The lesions include urticarial papules, plaques, target lesions, polycyclic wheals, and small vesicles. The lesions usually begin on the abdomen, often in striae, but usually spare the umbilicus. The eruption may become generalized but usually spares the palms and soles. Mucous membranes are not involved. It usually subsides in the second week after delivery. Patients are systemically well and the fetus is unaffected. The histology is characterized by dermal edema and a perivascular infiltrate of mononuclear cells and eosinophils in the upper dermis. Spongiosis may be present. Direct immunofluorescence studies are always negative. Treatment is symptomatic.
References
Taylor D, Pappo E, Aronson IK. Polymorphic eruption of pregnancy. Clin Dermatol. 2016 May-Jun;34(3):383-91.
Brandão P, Sousa-Faria B, Marinho C, Vieira-Enes P, Melo A, Mota L. Polymorphic eruption of pregnancy: review of literature. J Obstet Gynaecol. 2017 Feb;37(2):137-140.
Jo-David Fine, MD, MPH, FRCP, is board certified in internal medicine, dermatology, and diagnostic and laboratory immunodermatology. Dr Fine is currently professor of medicine (dermatology) and pediatrics at Vanderbilt University School of Medicine in Nashville, TN.
Ron J. Feldman, MD, PhD, is assistant professor in the department of dermatology at Emory University School of Medicine in Atlanta, GA.
1. This keratotic and hypertrophic lesion developed at the site of a previous discoid lupus erythematosus lesion. The diagnosis is:
d) Squamous cell carcinoma
There are an increasing number of reports of squamous cell carcinoma developing in sites of chronic inflammation and scarring in patients with discoid lupus erythematosus. The incidence is unknown; however, the link between discoid lupus erythematosus and squamous cell carcinoma suggests a cause and effect relationship. These lesions should not be mistaken for hypertrophic discoid lupus erythematosus or ostraceous or verrucous cutaneous lupus erythematosus.
Reference
Keith WD, Kelly AP, Sumrall AJ, Chabra A. Squamous cell carcinoma arising in lesions of discoid lupus erythematosus in black persons. Arch Dermatol. 1980;116(3):315-317.
2. This pruritic eruption began in the 33rd week of the patient’s first pregnancy and completely resolved in the first week following delivery of a healthy infant. Which one of the following is true of the eruption?
c) It usually spares the umbilicus
The eruption is polymorphic eruption of pregnancy or pruritic urticarial papules and plaques of pregnancy. Characterized clinically by onset usually in the last 5 weeks of pregnancy, with a higher incidence in first pregnancies. The lesions include urticarial papules, plaques, target lesions, polycyclic wheals, and small vesicles. The lesions usually begin on the abdomen, often in striae, but usually spare the umbilicus. The eruption may become generalized but usually spares the palms and soles. Mucous membranes are not involved. It usually subsides in the second week after delivery. Patients are systemically well and the fetus is unaffected. The histology is characterized by dermal edema and a perivascular infiltrate of mononuclear cells and eosinophils in the upper dermis. Spongiosis may be present. Direct immunofluorescence studies are always negative. Treatment is symptomatic.
References
Taylor D, Pappo E, Aronson IK. Polymorphic eruption of pregnancy. Clin Dermatol. 2016 May-Jun;34(3):383-91.
Brandão P, Sousa-Faria B, Marinho C, Vieira-Enes P, Melo A, Mota L. Polymorphic eruption of pregnancy: review of literature. J Obstet Gynaecol. 2017 Feb;37(2):137-140.
Jo-David Fine, MD, MPH, FRCP, is board certified in internal medicine, dermatology, and diagnostic and laboratory immunodermatology. Dr Fine is currently professor of medicine (dermatology) and pediatrics at Vanderbilt University School of Medicine in Nashville, TN.
Ron J. Feldman, MD, PhD, is assistant professor in the department of dermatology at Emory University School of Medicine in Atlanta, GA.
