Hemophilia B News

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Revolutionary Single-Dose Gene Therapy Offers New Hope for Adults with Hemophilia B

11/08/2024

A groundbreaking gene therapy for hemophilia B has shown remarkable success in reducing bleeding episodes and improving the quality of life for adult patients, according to a recent international phase III clinical trial.

A groundbreaking gene therapy...

11/08/2024

First Report Managed Care

News

New 4F-PCC Proves Effective in Rapid Reversal of Anticoagulation for Urgent Surgery, Clinical Trial Finds

09/10/2024

Lisa Kuhns , PhD, MD;

An investigational 4-factor prothrombin complex concentrate (4F-PCC) is as effective and safe as an FDA-approved 4F-PCC for rapidly reversing vitamin K antagonist (VKA) anticoagulation in patients requiring urgent surgery, according to a...

An investigational 4-factor...

09/10/2024

First Report Managed Care

News

Fitusiran Prophylaxis Shows Promise for Protection Against Bleeding for Patients With Hemophilia A or B

06/05/2024

Grace Taylor , MS, MA;

A phase 3 study evaluated the efficacy and safety of fitusiran in males with hemophilia A or B who were receiving bypassing agent (BPA)/clotting factor concentrate (CFC) prophylaxis.

A phase 3 study evaluated the...

06/05/2024

First Report Managed Care

News

Study Finds No Treatment-Related Adverse Events in Boys Treated With Purified FIX Concentrate

05/09/2024

Jolynn Tumolo ;

Purified factor IX (FIX) concentrate was effective in treating and preventing bleeding episodes in real-world pediatric patients 6 years and younger with hemophilia B, according to a study published in the Journal of Blood Medicine.

Purified factor IX (FIX)...

05/09/2024

First Report Managed Care

News

Rebalancing Coagulation Pathways and Human Factor 9 Gene Knock-In Strategy Identified for Hemophilia B

04/25/2024

Grace Taylor

A study published in Molecular Therapy Nucleic Acids highlights a treatment strategy for treating hemophilia B by combining rebalancing coagulation pathways and human factor 9 (hF9) gene knock-in (KI) using a lipid nanoparticle and...

A study published in Molecular...

04/25/2024

First Report Managed Care

News

Antibody Test Determines Eligibility for Hemophilia Gene Therapy

12/11/2023

Jolynn Tumolo ;

The US Food and Drug Administration’s recent approval of the AAV5 DetectCDx test marked the agency’s first-ever approval of a companion diagnostic test for a gene therapy product.

The US Food and Drug...

12/11/2023

First Report Managed Care

News

Patient Education on AAV Vectors for Hemophilia Essential to Prevent ‘Buyer’s Remorse’

11/10/2023

Jolynn Tumolo ;

Having long served as the model disorders for the development of gene therapy, hemophilia A (HA) and hemophilia B (HB) are currently benefitting from the role with the emergence of adeno-associated viral (AAV) vectors, according to a review...

Having long served as the model...

11/10/2023

First Report Managed Care

News

Changing Trends in Hemophilia Treatment

10/27/2023

Julie Gould ;

“With other novel therapies (including gene therapy) entering the US market, it is important to document the variability in existing prescribing practices among broad-based cohorts of clinicians,” explain study authors.

“With other novel therapies...

10/27/2023

First Report Managed Care

News

Gene Therapy Superior to Factor IX Replacement for Hemophilia B

04/17/2023

Jolynn Tumolo ;

Findings from a phase 3 trial suggest gene therapy was superior to prophylactic factor IX for decreasing bleeding in patients with hemophilia B.

Findings from a phase 3 trial...

04/17/2023

First Report Managed Care

News

For Most Patients, Factor Replacement Likely Unnecessary Up to 25 Years After Gene Therapy for Hemophilia B

03/02/2023

Jolynn Tumolo ;

Predictive analyses suggest a majority of patients with hemophilia B likely would achieve durable clotting factor levels after a single infusion of etranacogene dezaparvovec.

Predictive analyses suggest a...

03/02/2023

First Report Managed Care

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Is Sitting Just As Dangerous As Smoking?

01/20/2015

Kerri Fitzgerald ;

Emerging research has indicated that it is possible to meet current daily physical activity guidelines while still being too sedentary, which increases the risk of death and disease despite physical activity that is taking place.

Emerging research has indicated...

01/20/2015

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GOP raises more questions about healthcare waivers

08/15/2011

First Report Managed Care

Best Practices in Medicaid Claims Administration and Oversight

12/02/2014

Every Medicaid operation needs high-performing claims administration. With strict medical loss ratios as required by healthcare reform, ongoing regulatory changes, timeliness, and payment accuracy relevant to provider pricing and benefit...

Every Medicaid operation needs...

12/02/2014

First Report Managed Care

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U.S. warns Aetna over Medicare prescription policies

04/12/2010

First Report Managed Care

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Biologics: Changing the Treatment Scope for Psoriasis and Psoriatic Arthritis: References

12/01/2014

NULL

References 1. Levy LL, Solomon SM, Emer JJ. Biologics in the treatment of psoriasis and emerging new therapies in the pipeline. Psoriasis: Targets and Therapy. 2012;2:29-43. 2. Bhosle MJ, Kulkarni A, Feldman SR, Balkrishnan. Quality of life...

References 1. Levy LL, Solomon...

12/01/2014

First Report Managed Care

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Videos

Bridging the Gaps in Prior Authorization: Challenges, Solutions, and Collaboration for Better Patient Care

11/13/2024

David Sand, MD, MBA, chief medical officer at ZeOmega, discusses the challenges of prior authorization, emphasizing the need for transparency, evidence-based standards, collaboration between payers and providers, and the potential for...

David Sand, MD, MBA, chief...

11/13/2024

First Report Managed Care

Videos

The Evolving Role of CGRP-targeting Therapies in Migraine Prevention

10/31/2024

Richard Lipton, MD, provides insights on the American Headache Society’s position statement update on calcitonin gene-related peptide (CGRP)-targeting therapies as a first-line option for the prevention of migraine.

Richard Lipton, MD, provides...

10/31/2024

First Report Managed Care

Videos

Unmet Needs in the Treatment and Management of Non–Small Cell Lung Cancer

09/26/2024

Alexander Spira , MD, PhD;

Alexander I. Spira, MD, PhD, discusses significant unmet needs in the treatment and management of non–small cell lung cancer (NSCLC).

Alexander I. Spira, MD, PhD,...

09/26/2024

First Report Managed Care

Videos

Treatment Options for NSCLC: A Discussion on Coverage, Clinical Outcomes, and Payer Perspectives

09/25/2024

Learn about research developments in 1L therapy for NSCLC patients with EGFR mutations and how outcomes may impact coverage and reimbursement decisions for insurers.

Learn about research...

09/25/2024

First Report Managed Care

Videos

Addressing the Root Cause of a Common Ocular Condition: A Virtual Roundtable

09/04/2024

View a roundtable discussion on Demodex blepharitis, a prevalent ocular condition that often goes undiagnosed in patients.

View a roundtable discussion on...

09/04/2024

First Report Managed Care

Videos

Addressing Health Disparities and Promoting Equity: The Role of Advanced Imaging Solutions

08/15/2024

Guest expert Jordan Bazinsky discusses the challenges facing the medical imaging industry, the potential of AI and emerging technologies, the role of advanced imaging solutions in promoting health equity, and the key trends and challenges...

Guest expert Jordan Bazinsky...

08/15/2024

First Report Managed Care

Videos

Promising Therapies and Clinical Trials for Chronic Lymphocytic Leukemia

08/14/2024

Farrukh T. Awan , MD;

Farrukh Awan, MD, highlights promising therapies and clinical trials within the field of chronic lymphocytic leukemia (CLL).

Farrukh Awan, MD, highlights...

08/14/2024

Journal of Clinical Pathways

Videos

Evolving Health Care Contact Centers Into Drivers of Value-Based Care

07/31/2024

Discover how health care contact centers can transform into drivers of value-based care through AI, automation, upskilling agents, and rethinking workflows and metrics to improve patient outcomes and population health.

Discover how health care contact...

07/31/2024

First Report Managed Care

Videos

Enhancing Patient Medication Adherence: Insights and Strategies From Asembia 2024

06/11/2024

Lucille Accetta, PharmD, MBA, MSPH, Senior Vice President of CVS Specialty Operations

Key stakeholders in the health care industry gathered to discuss prevalent topics at this year's Asembia annual summit. Medication adherence emerged as one of the most talked-about issues. In a session led by Lucille Accetta, PharmD, MBA,...

Key stakeholders in the health...

06/11/2024

First Report Managed Care

Melissa Andel, Principal, CommonHealth Solutions, LLC

Videos

Navigating the Impact of the Inflation Reduction Act: Implications for Payers, Patients, and Manufacturers

05/24/2024

Melissa Andel, Principal, CommonHealth Solutions, LLC

Learn about the impacts of the Inflation Reduction Act on payers and patients, highlighting the changes in Medicare benefits and drug coverage coming in 2025 and 2026.

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