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Comparative Effectiveness Topic Center

Featured Article

Research Review
Comparing Intermittent Injectable Cabotegravir + Rilpivirine vs Daily Oral HIV Treatments: SOLAR Study Highlights
01/12/2024
Hannah Musick
In this research review, long-acting injectable regimen cabotegravir + rilpivirine (CAB+RPV LA) and daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment regimens for patients with HIV are compared in terms of...
In this research review, long-acting injectable regimen cabotegravir + rilpivirine (CAB+RPV LA) and daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment regimens for patients with HIV are compared in terms of...
In this research review,...
01/12/2024
First Report Managed Care
Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023

Danielle Sposato

Danielle Sposato
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021

Edan Stanley

Edan Stanley
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care
News
Secukinumab May be More Efficient for Psoriatic Arthritis
08/25/2020
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more...
08/25/2020
First Report Managed Care
News
Study Finds Comparable Short-Term Outcomes Among Psoriasis Biologics
07/20/2020
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning...
07/20/2020
First Report Managed Care
Conference Insider
Comparative Effectiveness Study Examines Safety, Efficacy of Biosimilar in Clinical Trial, Real-World Practice
07/19/2018
According to a presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, results from a randomized controlled trial were compared with a real-world cohort for the safety and efficacy of a biosimilar to treat...
According to a presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, results from a randomized controlled trial were compared with a real-world cohort for the safety and efficacy of a biosimilar to treat...
According to a presentation at...
07/19/2018
First Report Managed Care
Conference Insider
Urgent TAVR Has Beneficial Outcomes Compared With Elective TAVR
05/07/2018
Recent research presented at the ACC 2018 Scientific Session found that urgent or emergent transcatheter aortic valve replacement (TAVR) has acceptable outcomes when compared with elective TAVR. 
Recent research presented at the ACC 2018 Scientific Session found that urgent or emergent transcatheter aortic valve replacement (TAVR) has acceptable outcomes when compared with elective TAVR. 
Recent research presented at the...
05/07/2018
First Report Managed Care
News Connection
TAVR Improves Quality of Life Compared With Surgery
04/04/2018
A study in Age and Ageing found that patients who receive the minimally invasive procedure transcatheter aortic valve replacement (TAVR) had improved quality of life compared with patients who underwent surgery.
A study in Age and Ageing found that patients who receive the minimally invasive procedure transcatheter aortic valve replacement (TAVR) had improved quality of life compared with patients who underwent surgery.
A study in Age and Ageing found...
04/04/2018
First Report Managed Care
Conference Insider
TAVR Does Not Significantly Reduce Mortality Compared With Surgery
01/02/2018
Data presented at the AHA 2017 Scientific Sessions found that all-cause mortality among patients undergoing transcatheter aortic valve replacement (TAVR) was not significantly different compared with patients undergoing surgical aortic valve...
Data presented at the AHA 2017 Scientific Sessions found that all-cause mortality among patients undergoing transcatheter aortic valve replacement (TAVR) was not significantly different compared with patients undergoing surgical aortic valve...
Data presented at the AHA 2017...
01/02/2018
First Report Managed Care
Conference Insider
Oral, Subcutaneous Insulin Demonstrate Similar Efficacy
07/31/2017
A presentation at the American Diabetes Association’s 77th Scientific Sessions showed that oral insulin achieved similar HbA1c and fasting plasma glucose levels in patients with type 2 diabetes compared with subcutaneous insulin injections.
A presentation at the American Diabetes Association’s 77th Scientific Sessions showed that oral insulin achieved similar HbA1c and fasting plasma glucose levels in patients with type 2 diabetes compared with subcutaneous insulin injections.
A presentation at the American...
07/31/2017
First Report Managed Care
News Connection
Gilead’s Bictegravir Shows Equivalent Efficacy to Tivicay in Phase 3 Trials
06/08/2017
Multiple phase 3 HIV trials suggest fixed-dose combination treatment regimens containing Gilead's investigational agent bictegravir are noninferior to those containing GlaxoSmithKline’s Tivicay.
Multiple phase 3 HIV trials suggest fixed-dose combination treatment regimens containing Gilead's investigational agent bictegravir are noninferior to those containing GlaxoSmithKline’s Tivicay.
Multiple phase 3 HIV trials...
06/08/2017
First Report Managed Care

Newsfeed

News
Secukinumab May be More Efficient for Psoriatic Arthritis
08/25/2020
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more...
08/25/2020
First Report Managed Care
News
Study Finds Comparable Short-Term Outcomes Among Psoriasis Biologics
07/20/2020
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning...
07/20/2020
First Report Managed Care
News
Pradaxa Efficacy Comparable to Warfarin for Treating Patients with AF
08/18/2016
A recent post-hoc analysis from the RE-LY clinical trial of dabigatran (Pradaxa), found that patients with AF who received the treatment experienced the same benefits and risks relative to warfarin treatment, regardless of valvular heart...
A recent post-hoc analysis from the RE-LY clinical trial of dabigatran (Pradaxa), found that patients with AF who received the treatment experienced the same benefits and risks relative to warfarin treatment, regardless of valvular heart...
A recent post-hoc analysis from...
08/18/2016
First Report Managed Care

Literature Review

Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023

Danielle Sposato

Danielle Sposato
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021

Edan Stanley

Edan Stanley
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care
Literature Review
Promising Outcomes for SER-109: A New Approach to Managing Recurrent CDI
10/23/2023

Danielle Sposato

Danielle Sposato
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109...
10/23/2023
First Report Managed Care
Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023

Danielle Sposato

Danielle Sposato
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
A Look at the Impact, Prevalence of Demodex Blepharitis
12/06/2022
Edan Stanley
This article explores the incidence, prevalence, and management of Demodex Blepharitis.
This article explores the incidence, prevalence, and management of Demodex Blepharitis.
This article explores the...
12/06/2022
First Report Managed Care
Literature Review
Anti-CD38 Monoclonal Antibody for Multiple Myeloma: A Review of Clinical Trials
11/29/2022
Maria Asimopoulos
Several ongoing and upcoming clinical trials are testing the efficacy and safety of a monoclonal antibody in combination with other therapies for multiple myeloma.
Several ongoing and upcoming clinical trials are testing the efficacy and safety of a monoclonal antibody in combination with other therapies for multiple myeloma.
Several ongoing and upcoming...
11/29/2022
First Report Managed Care
Literature Review
Isatuximab Demonstrates Significant PFS Among Patients With Multiple Myeloma
09/23/2022
Edan Stanley
This literature review explores the latest progression-free survival data for a multiple myeloma therapy option.
This literature review explores the latest progression-free survival data for a multiple myeloma therapy option.
This literature review explores...
09/23/2022
First Report Managed Care
Literature Review
Bladder Cancers: What is Low-Grade Upper Tract Urothelial Carcinoma?
09/16/2022
Edan Stanley
This literature review explores key data related to the epidemiology, clinical presentation, and treatment considerations for patients with low-grade upper tract urothelial carcinoma.
This literature review explores key data related to the epidemiology, clinical presentation, and treatment considerations for patients with low-grade upper tract urothelial carcinoma.
This literature review explores...
09/16/2022
First Report Managed Care
Literature Review
Examining 177Lu-PSMA-617 as a Treatment for Metastatic Castration-resistant Prostate Cancer
09/16/2021
Jeff Craven
In this literature review, we explore the data from the phase 3 VISION trial recently presented at the 2021 virtual annual meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine, examining...
In this literature review, we explore the data from the phase 3 VISION trial recently presented at the 2021 virtual annual meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine, examining...
In this literature review, we...
09/16/2021
First Report Managed Care
Literature Review
Examining Benefits of Cannabidiol for Patients With Seizures
08/12/2021
Edan Stanley
For the purpose of this literature review, we examine the latest data presented at the American Academy of Neurology’s (AAN) 2021 Virtual Annual Meeting regarding the use of CBD for patients with seizure disorders including TSC.  
For the purpose of this literature review, we examine the latest data presented at the American Academy of Neurology’s (AAN) 2021 Virtual Annual Meeting regarding the use of CBD for patients with seizure disorders including TSC.  
For the purpose of this...
08/12/2021
First Report Managed Care
Literature Review
Examining Dry Eye Disease Flare Treatments
05/28/2021
Edan Stanley
With a newly proposed and easily applicable definition for dry eye disease, researchers believe the condition can be diagnosed with more consistency as well as inform future trials and research. 
With a newly proposed and easily applicable definition for dry eye disease, researchers believe the condition can be diagnosed with more consistency as well as inform future trials and research. 
With a newly proposed and easily...
05/28/2021
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021

Edan Stanley

Edan Stanley
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care

First Report

Dupilumab Associated With Reduced Severe Asthma Exacerbation Rates Compared to Other Biologics
Per the results of an indirect treatment comparison, researchers found that dupilumab is associated with lower severe asthma exacerbation rates than patients treated with anti-IL-5s and o...
Weekly Dose of Hemophilia Factor VIII Therapy Delivers Significant Bleed Protection
Pegloticase Benefit Enhanced When Combined With Methotrexate for Patients With Chronic Gout
HCRU Burden of Chronic vs Episodic Migraine and Effect of Early vs Late Nonoral Triptan Use
Zanubrutinib Exhibits Superior Overall Response Rate for Adult Patients With Chronic Lymphocytic Leukemia
Access to Acute Treatments for Migraine Can Reduce Costs for Employers, Health Care System
Addition of Daratumumab to a Treatment Plan for Transplant Ineligible Patients With Multiple Myeloma Proves Beneficial
Atezolizumab Demonstrates Positive Disease-free Survival Benefit Among Patients With NSCLC
Data Supports Progression-Free Survival, Overall Survival for Long-Term CLL/SLL Treatment
ICER Report Ranks Value, Clinical Effectiveness of Dupilumab and Other AD Treatments
Dupilumab Reduces Type 2 Inflammation, May Offer Clinical Benefits for Multiple Comorbid Diseases

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CMS Demonstration Projects for Dual Eligibles
06/19/2012

Tim Casey

Tim Casey
For years, the federal government and states have attempted to rein in costs associated with Medicare and Medicaid.
For years, the federal government and states have attempted to rein in costs associated with Medicare and Medicaid.
For years, the federal...
06/19/2012
First Report Managed Care
News
Republicans seek to reassure elderly on Medicare
04/25/2011
04/25/2011
First Report Managed Care
News
Medicare Cuts for Readmissions to Target Large Hospitals
01/24/2013
01/24/2013
First Report Managed Care
News
Analysis of CMS Bundled-Payments Program Provides Inconclusive Results
09/20/2016
Performance results are mixed after the first year of CMS’ voluntary Bundled Payments for Care Improvement initiative.
Performance results are mixed after the first year of CMS’ voluntary Bundled Payments for Care Improvement initiative.
Performance results are mixed...
09/20/2016
First Report Managed Care
News
Increased HCRU, Direct Costs Associated With Alopecia Areata
07/29/2022
Samantha Matthews
Researchers assessed all-cause health care resource utilization and direct health care costs in US adults with alopecia areata with or without alopecia totalis or alopecia universalis.
Researchers assessed all-cause health care resource utilization and direct health care costs in US adults with alopecia areata with or without alopecia totalis or alopecia universalis.
Researchers assessed all-cause...
07/29/2022
First Report Managed Care

Video Insights

Hayward
Videos
Evolving Health Care Contact Centers Into Drivers of Value-Based Care
07/31/2024
Discover how health care contact centers can transform into drivers of value-based care through AI, automation, upskilling agents, and rethinking workflows and metrics to improve patient outcomes and population health.
Discover how health care contact centers can transform into drivers of value-based care through AI, automation, upskilling agents, and rethinking workflows and metrics to improve patient outcomes and population health.
Discover how health care contact...
07/31/2024
First Report Managed Care
Lucille Accetta Headshot
Videos
Enhancing Patient Medication Adherence: Insights and Strategies From Asembia 2024
06/11/2024
Lucille Accetta, PharmD, MBA, MSPH, Senior Vice President of CVS Specialty Operations
Key stakeholders in the health care industry gathered to discuss prevalent topics at this year's Asembia annual summit. Medication adherence emerged as one of the most talked-about issues. In a session led by Lucille Accetta, PharmD, MBA,...
Key stakeholders in the health care industry gathered to discuss prevalent topics at this year's Asembia annual summit. Medication adherence emerged as one of the most talked-about issues. In a session led by Lucille Accetta, PharmD, MBA,...
Key stakeholders in the health...
06/11/2024
First Report Managed Care
Melissa Andel, Principal, CommonHealth Solutions, LLC
Videos
Navigating the Impact of the Inflation Reduction Act: Implications for Payers, Patients, and Manufacturers
05/24/2024
Melissa Andel, Principal, CommonHealth Solutions, LLC
Learn about the impacts of the Inflation Reduction Act on payers and patients, highlighting the changes in Medicare benefits and drug coverage coming in 2025 and 2026.
Learn about the impacts of the Inflation Reduction Act on payers and patients, highlighting the changes in Medicare benefits and drug coverage coming in 2025 and 2026.
Learn about the impacts of the...
05/24/2024
First Report Managed Care
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Navigating Payment Models in the CGT Landscape: Insights and Innovations
05/21/2024
Joe DePinto, Head of Cell, Gene, and Advanced Therapies, McKesson
An expert discusses the evolution and challenges of payment models in the cell and gene therapy (CGT) space reviewed during his session at Asembia 2024.
An expert discusses the evolution and challenges of payment models in the cell and gene therapy (CGT) space reviewed during his session at Asembia 2024.
An expert discusses the...
05/21/2024
First Report Managed Care
Jennifer L. Mathieu Senior Vice President, Professional and Government Affairs at AMCP
Videos
Unlocking the Future of Managed Care Pharmacy: A Deep Dive into Federal Legislation and Regulations
05/15/2024
Jennifer L. Mathieu Senior Vice President, Professional and Government Affairs, AMCP
Learn about developments in federal legislation and regulations within the pharmacy landscape shaping the future of managed care in an interview with a session presenter from AMCP 2024.
Learn about developments in federal legislation and regulations within the pharmacy landscape shaping the future of managed care in an interview with a session presenter from AMCP 2024.
Learn about developments in...
05/15/2024
First Report Managed Care
Tejaswi Kompala
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Personalizing Weight Loss Management With GLP-1 Agonists
04/05/2024

Featuring Tejaswi Kompala, MD, head of cardiometabolic clinical strategy, Teladoc 

Featuring Tejaswi Kompala, MD, head o...
Delve into the rising demand for anti-obesity medications, the complexities of obesity management, and the importance of personalized approaches in improving cardiometabolic health in this insightful interview.
Delve into the rising demand for anti-obesity medications, the complexities of obesity management, and the importance of personalized approaches in improving cardiometabolic health in this insightful interview.
Delve into the rising demand for...
04/05/2024
First Report Managed Care
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Integrating Behavioral Health Services to Reduce ED Visits: Substance Use Disorder and Social Determinants of Health
03/27/2024

Featuring Tom Zaubler, MD, MPH, CMO at NeuroFlow

Featuring Tom Zaubler, MD, MPH, CMO a...
Join us for the continuation of an engaging two-part series showcasing an expert dedicated to reducing emergency department visits through the integration of behavioral health practices. Dr Zaubler will share invaluable insights into...
Join us for the continuation of an engaging two-part series showcasing an expert dedicated to reducing emergency department visits through the integration of behavioral health practices. Dr Zaubler will share invaluable insights into...
Join us for the continuation of...
03/27/2024
First Report Managed Care
Zaubler Headshot
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Integrating Behavioral Health Services to Reduce ED Visits: Suicide Prevention and Preemptive Primary Care
03/25/2024

Featuring Tom Zaubler, MD, MPH, CMO at NeuroFlow

Featuring Tom Zaubler, MD, MPH, CMO a...
Come join us for the first installment of a captivating two-part series featuring an expert committed to minimizing emergency department visits through the implementation of behavioral health integrations. Dr Zaubler will offer valuable...
Come join us for the first installment of a captivating two-part series featuring an expert committed to minimizing emergency department visits through the implementation of behavioral health integrations. Dr Zaubler will offer valuable...
Come join us for the first...
03/25/2024
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Navigating the Evolution of Digital Solutions in Health Care
02/27/2024

Featuring Yash Prajapati, consultant at ZS Associates 

Featuring Yash Prajapati, consultant ...
Join us in exploring the challenges and opportunities in the development, approval, and integration of digital therapeutic solutions with ZS Associates consultant Yash Prajapati.
Join us in exploring the challenges and opportunities in the development, approval, and integration of digital therapeutic solutions with ZS Associates consultant Yash Prajapati.
Join us in exploring the...
02/27/2024
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Advancements and Challenges in Diabetes Management
02/27/2024

Featuring Mansur Shomali, MD, chief medical officer at Welldoc, endocrinologist at MedStar Health 

Featuring Mansur Shomali, MD, chief m...
Learn about the state of digital therapeutics for disease management such as diabetes care in terms of cost, outcomes, integration, and more with Dr Mansur Shomali, CMO at Welldoc.
Learn about the state of digital therapeutics for disease management such as diabetes care in terms of cost, outcomes, integration, and more with Dr Mansur Shomali, CMO at Welldoc.
Learn about the state of digital...
02/27/2024
First Report Managed Care

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