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Comparative Effectiveness Topic Center

Featured Article

Research Review
Comparing Intermittent Injectable Cabotegravir + Rilpivirine vs Daily Oral HIV Treatments: SOLAR Study Highlights
01/12/2024
In this research review, long-acting injectable regimen cabotegravir + rilpivirine (CAB+RPV LA) and daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment regimens for patients with HIV are compared in terms of...
In this research review, long-acting injectable regimen cabotegravir + rilpivirine (CAB+RPV LA) and daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment regimens for patients with HIV are compared in terms of...
In this research review,...
01/12/2024
First Report Managed Care
Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care
News
Secukinumab May be More Efficient for Psoriatic Arthritis
08/25/2020
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more...
08/25/2020
First Report Managed Care
News
Study Finds Comparable Short-Term Outcomes Among Psoriasis Biologics
07/20/2020
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning...
07/20/2020
First Report Managed Care
Conference Insider
Comparative Effectiveness Study Examines Safety, Efficacy of Biosimilar in Clinical Trial, Real-World Practice
07/19/2018
According to a presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, results from a randomized controlled trial were compared with a real-world cohort for the safety and efficacy of a biosimilar to treat...
According to a presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, results from a randomized controlled trial were compared with a real-world cohort for the safety and efficacy of a biosimilar to treat...
According to a presentation at...
07/19/2018
First Report Managed Care
Conference Insider
Urgent TAVR Has Beneficial Outcomes Compared With Elective TAVR
05/07/2018
Recent research presented at the ACC 2018 Scientific Session found that urgent or emergent transcatheter aortic valve replacement (TAVR) has acceptable outcomes when compared with elective TAVR. 
Recent research presented at the ACC 2018 Scientific Session found that urgent or emergent transcatheter aortic valve replacement (TAVR) has acceptable outcomes when compared with elective TAVR. 
Recent research presented at the...
05/07/2018
First Report Managed Care
News Connection
TAVR Improves Quality of Life Compared With Surgery
04/04/2018
A study in Age and Ageing found that patients who receive the minimally invasive procedure transcatheter aortic valve replacement (TAVR) had improved quality of life compared with patients who underwent surgery.
A study in Age and Ageing found that patients who receive the minimally invasive procedure transcatheter aortic valve replacement (TAVR) had improved quality of life compared with patients who underwent surgery.
A study in Age and Ageing found...
04/04/2018
First Report Managed Care
Conference Insider
TAVR Does Not Significantly Reduce Mortality Compared With Surgery
01/02/2018
Data presented at the AHA 2017 Scientific Sessions found that all-cause mortality among patients undergoing transcatheter aortic valve replacement (TAVR) was not significantly different compared with patients undergoing surgical aortic valve...
Data presented at the AHA 2017 Scientific Sessions found that all-cause mortality among patients undergoing transcatheter aortic valve replacement (TAVR) was not significantly different compared with patients undergoing surgical aortic valve...
Data presented at the AHA 2017...
01/02/2018
First Report Managed Care
Conference Insider
Oral, Subcutaneous Insulin Demonstrate Similar Efficacy
07/31/2017
A presentation at the American Diabetes Association’s 77th Scientific Sessions showed that oral insulin achieved similar HbA1c and fasting plasma glucose levels in patients with type 2 diabetes compared with subcutaneous insulin injections.
A presentation at the American Diabetes Association’s 77th Scientific Sessions showed that oral insulin achieved similar HbA1c and fasting plasma glucose levels in patients with type 2 diabetes compared with subcutaneous insulin injections.
A presentation at the American...
07/31/2017
First Report Managed Care
News Connection
Gilead’s Bictegravir Shows Equivalent Efficacy to Tivicay in Phase 3 Trials
06/08/2017
Multiple phase 3 HIV trials suggest fixed-dose combination treatment regimens containing Gilead's investigational agent bictegravir are noninferior to those containing GlaxoSmithKline’s Tivicay.
Multiple phase 3 HIV trials suggest fixed-dose combination treatment regimens containing Gilead's investigational agent bictegravir are noninferior to those containing GlaxoSmithKline’s Tivicay.
Multiple phase 3 HIV trials...
06/08/2017
First Report Managed Care

Newsfeed

News
Secukinumab May be More Efficient for Psoriatic Arthritis
08/25/2020
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more...
08/25/2020
First Report Managed Care
News
Study Finds Comparable Short-Term Outcomes Among Psoriasis Biologics
07/20/2020
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning...
07/20/2020
First Report Managed Care
News
Pradaxa Efficacy Comparable to Warfarin for Treating Patients with AF
08/18/2016
A recent post-hoc analysis from the RE-LY clinical trial of dabigatran (Pradaxa), found that patients with AF who received the treatment experienced the same benefits and risks relative to warfarin treatment, regardless of valvular heart...
A recent post-hoc analysis from the RE-LY clinical trial of dabigatran (Pradaxa), found that patients with AF who received the treatment experienced the same benefits and risks relative to warfarin treatment, regardless of valvular heart...
A recent post-hoc analysis from...
08/18/2016
First Report Managed Care

Literature Review

Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care
Literature Review
Promising Outcomes for SER-109: A New Approach to Managing Recurrent CDI
10/23/2023
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109...
10/23/2023
First Report Managed Care
Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
A Look at the Impact, Prevalence of Demodex Blepharitis
12/06/2022
This article explores the incidence, prevalence, and management of Demodex Blepharitis.
This article explores the incidence, prevalence, and management of Demodex Blepharitis.
This article explores the...
12/06/2022
First Report Managed Care
Literature Review
Anti-CD38 Monoclonal Antibody for Multiple Myeloma: A Review of Clinical Trials
11/29/2022
Several ongoing and upcoming clinical trials are testing the efficacy and safety of a monoclonal antibody in combination with other therapies for multiple myeloma.
Several ongoing and upcoming clinical trials are testing the efficacy and safety of a monoclonal antibody in combination with other therapies for multiple myeloma.
Several ongoing and upcoming...
11/29/2022
First Report Managed Care
Literature Review
Isatuximab Demonstrates Significant PFS Among Patients With Multiple Myeloma
09/23/2022
This literature review explores the latest progression-free survival data for a multiple myeloma therapy option.
This literature review explores the latest progression-free survival data for a multiple myeloma therapy option.
This literature review explores...
09/23/2022
First Report Managed Care
Literature Review
Bladder Cancers: What is Low-Grade Upper Tract Urothelial Carcinoma?
09/16/2022
This literature review explores key data related to the epidemiology, clinical presentation, and treatment considerations for patients with low-grade upper tract urothelial carcinoma.
This literature review explores key data related to the epidemiology, clinical presentation, and treatment considerations for patients with low-grade upper tract urothelial carcinoma.
This literature review explores...
09/16/2022
First Report Managed Care
Literature Review
Examining 177Lu-PSMA-617 as a Treatment for Metastatic Castration-resistant Prostate Cancer
09/16/2021
In this literature review, we explore the data from the phase 3 VISION trial recently presented at the 2021 virtual annual meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine, examining...
In this literature review, we explore the data from the phase 3 VISION trial recently presented at the 2021 virtual annual meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine, examining...
In this literature review, we...
09/16/2021
First Report Managed Care
Literature Review
Examining Benefits of Cannabidiol for Patients With Seizures
08/12/2021
For the purpose of this literature review, we examine the latest data presented at the American Academy of Neurology’s (AAN) 2021 Virtual Annual Meeting regarding the use of CBD for patients with seizure disorders including TSC.  
For the purpose of this literature review, we examine the latest data presented at the American Academy of Neurology’s (AAN) 2021 Virtual Annual Meeting regarding the use of CBD for patients with seizure disorders including TSC.  
For the purpose of this...
08/12/2021
First Report Managed Care
Literature Review
Examining Dry Eye Disease Flare Treatments
05/28/2021
With a newly proposed and easily applicable definition for dry eye disease, researchers believe the condition can be diagnosed with more consistency as well as inform future trials and research. 
With a newly proposed and easily applicable definition for dry eye disease, researchers believe the condition can be diagnosed with more consistency as well as inform future trials and research. 
With a newly proposed and easily...
05/28/2021
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care

First Report

Dupilumab Associated With Reduced Severe Asthma Exacerbation Rates Compared to Other Biologics
Per the results of an indirect treatment comparison, researchers found that dupilumab is associated with lower severe asthma exacerbation rates than patients treated with anti-IL-5s and o...
Weekly Dose of Hemophilia Factor VIII Therapy Delivers Significant Bleed Protection
Pegloticase Benefit Enhanced When Combined With Methotrexate for Patients With Chronic Gout
HCRU Burden of Chronic vs Episodic Migraine and Effect of Early vs Late Nonoral Triptan Use
Zanubrutinib Exhibits Superior Overall Response Rate for Adult Patients With Chronic Lymphocytic Leukemia
Access to Acute Treatments for Migraine Can Reduce Costs for Employers, Health Care System
Addition of Daratumumab to a Treatment Plan for Transplant Ineligible Patients With Multiple Myeloma Proves Beneficial
Atezolizumab Demonstrates Positive Disease-free Survival Benefit Among Patients With NSCLC
Data Supports Progression-Free Survival, Overall Survival for Long-Term CLL/SLL Treatment
ICER Report Ranks Value, Clinical Effectiveness of Dupilumab and Other AD Treatments
Dupilumab Reduces Type 2 Inflammation, May Offer Clinical Benefits for Multiple Comorbid Diseases
FRMC Volume 21, Issue 3

Current Issue

September 2024
Volume 21
Issue 3
Current Issue
Issue Archive

What's Trending?

News
Pfizer’s Biosimilar Debuting in November, Less Expensive Than Remicade
10/19/2016
Pfizer recently announced that its biosimilar copy of Remicade, Inflectra, will hit the market in November at a list price 15% less than the competition.
Pfizer recently announced that its biosimilar copy of Remicade, Inflectra, will hit the market in November at a list price 15% less than the competition.
Pfizer recently announced that...
10/19/2016
First Report Managed Care
News
Even With Biologics, Asthma Not Well Controlled in Most Patients With Severe Disease
06/10/2022
Researchers identified unmet need in US patients with severe asthma who have residual disease despite the use of biologics. 
Researchers identified unmet need in US patients with severe asthma who have residual disease despite the use of biologics. 
Researchers identified unmet...
06/10/2022
First Report Managed Care
Orteronel to Treat Nonmetastatic Castration-Resistant Prostate Cancer
07/23/2012
Chicago—An analysis of an ongoing phase 2 study found that patients with nonmetastatic, castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA) reacted well to and managed toxicities when taking orteronel, an...
Chicago—An analysis of an ongoing phase 2 study found that patients with nonmetastatic, castration-resistant prostate cancer (nmCRPC) and rising prostate-specific antigen (PSA) reacted well to and managed toxicities when taking orteronel, an...
Chicago—An analysis of an...
07/23/2012
First Report Managed Care
News
Vertex’s hepatitis C drug aces review
04/27/2011
04/27/2011
First Report Managed Care
News
Uninsured less likely to get heart meds
02/05/2013
02/05/2013
First Report Managed Care

Video Insights

Videos
Bridging the Gaps in Prior Authorization: Challenges, Solutions, and Collaboration for Better Patient Care
11/13/2024
David Sand, MD, MBA, chief medical officer at ZeOmega, discusses the challenges of prior authorization, emphasizing the need for transparency, evidence-based standards, collaboration between payers and providers, and the potential for...
David Sand, MD, MBA, chief medical officer at ZeOmega, discusses the challenges of prior authorization, emphasizing the need for transparency, evidence-based standards, collaboration between payers and providers, and the potential for...
David Sand, MD, MBA, chief...
11/13/2024
First Report Managed Care
Richard Lipton, MD
Videos
The Evolving Role of CGRP-targeting Therapies in Migraine Prevention
10/31/2024
Richard Lipton, MD, provides insights on the American Headache Society’s position statement update on calcitonin gene-related peptide (CGRP)-targeting therapies as a first-line option for the prevention of migraine.
Richard Lipton, MD, provides insights on the American Headache Society’s position statement update on calcitonin gene-related peptide (CGRP)-targeting therapies as a first-line option for the prevention of migraine.
Richard Lipton, MD, provides...
10/31/2024
First Report Managed Care
Alexander Spira, MD, PhD
Videos
Unmet Needs in the Treatment and Management of Non–Small Cell Lung Cancer
09/26/2024
Alexander I. Spira, MD, PhD, discusses significant unmet needs in the treatment and management of non–small cell lung cancer (NSCLC).
Alexander I. Spira, MD, PhD, discusses significant unmet needs in the treatment and management of non–small cell lung cancer (NSCLC).
Alexander I. Spira, MD, PhD,...
09/26/2024
First Report Managed Care
Videos
Treatment Options for NSCLC: A Discussion on Coverage, Clinical Outcomes, and Payer Perspectives
09/25/2024
Learn about research developments in 1L therapy for NSCLC patients with EGFR mutations and how outcomes may impact coverage and reimbursement decisions for insurers.
Learn about research developments in 1L therapy for NSCLC patients with EGFR mutations and how outcomes may impact coverage and reimbursement decisions for insurers.
Learn about research...
09/25/2024
First Report Managed Care
Title Card
Videos
Addressing the Root Cause of a Common Ocular Condition: A Virtual Roundtable
09/04/2024
View a roundtable discussion on Demodex blepharitis, a prevalent ocular condition that often goes undiagnosed in patients.
View a roundtable discussion on Demodex blepharitis, a prevalent ocular condition that often goes undiagnosed in patients.
View a roundtable discussion on...
09/04/2024
First Report Managed Care
Jordan Bazinsky
Videos
Addressing Health Disparities and Promoting Equity: The Role of Advanced Imaging Solutions
08/15/2024
Guest expert Jordan Bazinsky discusses the challenges facing the medical imaging industry, the potential of AI and emerging technologies, the role of advanced imaging solutions in promoting health equity, and the key trends and challenges...
Guest expert Jordan Bazinsky discusses the challenges facing the medical imaging industry, the potential of AI and emerging technologies, the role of advanced imaging solutions in promoting health equity, and the key trends and challenges...
Guest expert Jordan Bazinsky...
08/15/2024
First Report Managed Care
Farrukh Awan, MD
Videos
Promising Therapies and Clinical Trials for Chronic Lymphocytic Leukemia
08/14/2024
Farrukh Awan, MD, highlights promising therapies and clinical trials within the field of chronic lymphocytic leukemia (CLL).
Farrukh Awan, MD, highlights promising therapies and clinical trials within the field of chronic lymphocytic leukemia (CLL).
Farrukh Awan, MD, highlights...
08/14/2024
Journal of Clinical Pathways
Hayward
Videos
Evolving Health Care Contact Centers Into Drivers of Value-Based Care
07/31/2024
Discover how health care contact centers can transform into drivers of value-based care through AI, automation, upskilling agents, and rethinking workflows and metrics to improve patient outcomes and population health.
Discover how health care contact centers can transform into drivers of value-based care through AI, automation, upskilling agents, and rethinking workflows and metrics to improve patient outcomes and population health.
Discover how health care contact...
07/31/2024
First Report Managed Care
Lucille Accetta Headshot
Videos
Enhancing Patient Medication Adherence: Insights and Strategies From Asembia 2024
06/11/2024
Lucille Accetta, PharmD, MBA, MSPH, Senior Vice President of CVS Specialty Operations
Key stakeholders in the health care industry gathered to discuss prevalent topics at this year's Asembia annual summit. Medication adherence emerged as one of the most talked-about issues. In a session led by Lucille Accetta, PharmD, MBA,...
Key stakeholders in the health care industry gathered to discuss prevalent topics at this year's Asembia annual summit. Medication adherence emerged as one of the most talked-about issues. In a session led by Lucille Accetta, PharmD, MBA,...
Key stakeholders in the health...
06/11/2024
First Report Managed Care
Melissa Andel, Principal, CommonHealth Solutions, LLC
Videos
Navigating the Impact of the Inflation Reduction Act: Implications for Payers, Patients, and Manufacturers
05/24/2024
Melissa Andel, Principal, CommonHealth Solutions, LLC
Learn about the impacts of the Inflation Reduction Act on payers and patients, highlighting the changes in Medicare benefits and drug coverage coming in 2025 and 2026.
Learn about the impacts of the Inflation Reduction Act on payers and patients, highlighting the changes in Medicare benefits and drug coverage coming in 2025 and 2026.
Learn about the impacts of the...
05/24/2024
First Report Managed Care

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