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Clostridioides difficile Topic Center

Featured Article

News
Fecal Microbiota Transplant for Patients With IBD and rCDI: Safety and Efficacy
03/28/2024

Emry Lloyd

Emry Lloyd
Patients with recurrent Clostridioides difficile infection have shown significant results when administered a fecal microbiota transplant. This study evaluated the safety and efficacy of using a fecal microbiota transplant for patients with...
Patients with recurrent Clostridioides difficile infection have shown significant results when administered a fecal microbiota transplant. This study evaluated the safety and efficacy of using a fecal microbiota transplant for patients with...
Patients with recurrent...
03/28/2024
First Report Managed Care
News
Two-Step Testing Linked With Lower Rate of CDI Treatment in Colonized Patients
03/14/2024
Switching to two-step algorithm testing for Clostridioides difficile infection correlated with lower rates of treatment, helping to differentiate colonization from active infection, according to a study published in Clinical Microbiology and...
Switching to two-step algorithm testing for Clostridioides difficile infection correlated with lower rates of treatment, helping to differentiate colonization from active infection, according to a study published in Clinical Microbiology and...
Switching to two-step algorithm...
03/14/2024
First Report Managed Care
News
HexSDF and HexRK are Required for Clostridioides difficile Synthesis, Which Impacts Resistance to Daptomycin and Bacitracin
11/15/2023
“C difficile is a major cause of hospital-acquired diarrhea and represents an urgent concern due to the prevalence of antibiotic resistance and the rate of recurrent infections,” wrote Anthony Pannullo, Department of Microbiology and...
“C difficile is a major cause of hospital-acquired diarrhea and represents an urgent concern due to the prevalence of antibiotic resistance and the rate of recurrent infections,” wrote Anthony Pannullo, Department of Microbiology and...
“C difficile is a major cause of...
11/15/2023
First Report Managed Care
Quiz
CDI Risk Factors
10/23/2023
What is the primary risk factor for Clostridioides difficile infection?
What is the primary risk factor for Clostridioides difficile infection?
What is the primary risk factor...
10/23/2023
First Report Managed Care
alpesh amin
Podcasts
How Does CDI Impact Health Care Utilization, Costs in Older Patients?
10/23/2023
Alpesh Amin, MD, MBA , professor and chair, University of California, discusses the results of a recent study, and explains why better treatments to reduce primary C difficile infection and recurrences in older adults can lower the mortality...
Alpesh Amin, MD, MBA , professor and chair, University of California, discusses the results of a recent study, and explains why better treatments to reduce primary C difficile infection and recurrences in older adults can lower the mortality...
Alpesh Amin, MD, MBA , professor...
10/23/2023
First Report Managed Care
Literature Review
Promising Outcomes for SER-109: A New Approach to Managing Recurrent CDI
10/23/2023
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109...
10/23/2023
First Report Managed Care
News
Comprehensive C difficile Infection Management Approach
10/17/2023
“Clinical treatment and management need to be multifaceted and consider not just pharmaceutical intervention but a holistic approach to the patient’s experience both during and after CDI, acknowledging the potential psychological and social...
“Clinical treatment and management need to be multifaceted and consider not just pharmaceutical intervention but a holistic approach to the patient’s experience both during and after CDI, acknowledging the potential psychological and social...
“Clinical treatment and...
10/17/2023
First Report Managed Care
News
Navigating CDI Prevention Implementation: Frontline Insights from VA Health Care Facilities
10/11/2023
This research examines the key factors influencing Clostridioides difficile infection (CDI) prevention practices, highlighting the role of organizational commitment, communication, standardization, and the limitations of role hierarchies...
This research examines the key factors influencing Clostridioides difficile infection (CDI) prevention practices, highlighting the role of organizational commitment, communication, standardization, and the limitations of role hierarchies...
This research examines the key...
10/11/2023
First Report Managed Care
News
Study Identifies Challenges and Improvement Opportunities Relating to Faecal Microbiota Transplantation for C difficile Infections
10/02/2023
A comprehensive understanding of how to develop and cultivate appropriate faecal microbiota transplantation (FMT) capacity is crucial for both health care providers and policymakers striving to enhance patient care for those with...
A comprehensive understanding of how to develop and cultivate appropriate faecal microbiota transplantation (FMT) capacity is crucial for both health care providers and policymakers striving to enhance patient care for those with...
A comprehensive understanding of...
10/02/2023
First Report Managed Care
News
Study Finds Substantial Gaps in Nurse Understanding of CDI Prevention
09/27/2023
A study published in the journal Antibiotics found that less than one-third of the participating nurses knew that using soap and water is the recommended handwashing method to prevent the spread of CDI effectively.
A study published in the journal Antibiotics found that less than one-third of the participating nurses knew that using soap and water is the recommended handwashing method to prevent the spread of CDI effectively.
A study published in the journal...
09/27/2023
First Report Managed Care
News
Transmission of C difficile Between People and Pets Appears Rare
09/26/2023
“It is unclear why pets appear to only infrequently acquire C difficile from their owners,” researchers wrote. “It may be that the canine gut microbiota is better able to provide colonization resistance against C difficile, even when in an...
“It is unclear why pets appear to only infrequently acquire C difficile from their owners,” researchers wrote. “It may be that the canine gut microbiota is better able to provide colonization resistance against C difficile, even when in an...
“It is unclear why pets appear...
09/26/2023
First Report Managed Care

Newsfeed

News
Fecal Microbiota Transplant for Patients With IBD and rCDI: Safety and Efficacy
03/28/2024

Emry Lloyd

Emry Lloyd
Patients with recurrent Clostridioides difficile infection have shown significant results when administered a fecal microbiota transplant. This study evaluated the safety and efficacy of using a fecal microbiota transplant for patients with...
Patients with recurrent Clostridioides difficile infection have shown significant results when administered a fecal microbiota transplant. This study evaluated the safety and efficacy of using a fecal microbiota transplant for patients with...
Patients with recurrent...
03/28/2024
First Report Managed Care
News
Two-Step Testing Linked With Lower Rate of CDI Treatment in Colonized Patients
03/14/2024
Switching to two-step algorithm testing for Clostridioides difficile infection correlated with lower rates of treatment, helping to differentiate colonization from active infection, according to a study published in Clinical Microbiology and...
Switching to two-step algorithm testing for Clostridioides difficile infection correlated with lower rates of treatment, helping to differentiate colonization from active infection, according to a study published in Clinical Microbiology and...
Switching to two-step algorithm...
03/14/2024
First Report Managed Care
News
HexSDF and HexRK are Required for Clostridioides difficile Synthesis, Which Impacts Resistance to Daptomycin and Bacitracin
11/15/2023
“C difficile is a major cause of hospital-acquired diarrhea and represents an urgent concern due to the prevalence of antibiotic resistance and the rate of recurrent infections,” wrote Anthony Pannullo, Department of Microbiology and...
“C difficile is a major cause of hospital-acquired diarrhea and represents an urgent concern due to the prevalence of antibiotic resistance and the rate of recurrent infections,” wrote Anthony Pannullo, Department of Microbiology and...
“C difficile is a major cause of...
11/15/2023
First Report Managed Care
News
Comprehensive C difficile Infection Management Approach
10/17/2023
“Clinical treatment and management need to be multifaceted and consider not just pharmaceutical intervention but a holistic approach to the patient’s experience both during and after CDI, acknowledging the potential psychological and social...
“Clinical treatment and management need to be multifaceted and consider not just pharmaceutical intervention but a holistic approach to the patient’s experience both during and after CDI, acknowledging the potential psychological and social...
“Clinical treatment and...
10/17/2023
First Report Managed Care
News
Navigating CDI Prevention Implementation: Frontline Insights from VA Health Care Facilities
10/11/2023
This research examines the key factors influencing Clostridioides difficile infection (CDI) prevention practices, highlighting the role of organizational commitment, communication, standardization, and the limitations of role hierarchies...
This research examines the key factors influencing Clostridioides difficile infection (CDI) prevention practices, highlighting the role of organizational commitment, communication, standardization, and the limitations of role hierarchies...
This research examines the key...
10/11/2023
First Report Managed Care
News
Study Identifies Challenges and Improvement Opportunities Relating to Faecal Microbiota Transplantation for C difficile Infections
10/02/2023
A comprehensive understanding of how to develop and cultivate appropriate faecal microbiota transplantation (FMT) capacity is crucial for both health care providers and policymakers striving to enhance patient care for those with...
A comprehensive understanding of how to develop and cultivate appropriate faecal microbiota transplantation (FMT) capacity is crucial for both health care providers and policymakers striving to enhance patient care for those with...
A comprehensive understanding of...
10/02/2023
First Report Managed Care
News
Study Finds Substantial Gaps in Nurse Understanding of CDI Prevention
09/27/2023
A study published in the journal Antibiotics found that less than one-third of the participating nurses knew that using soap and water is the recommended handwashing method to prevent the spread of CDI effectively.
A study published in the journal Antibiotics found that less than one-third of the participating nurses knew that using soap and water is the recommended handwashing method to prevent the spread of CDI effectively.
A study published in the journal...
09/27/2023
First Report Managed Care
News
Transmission of C difficile Between People and Pets Appears Rare
09/26/2023
“It is unclear why pets appear to only infrequently acquire C difficile from their owners,” researchers wrote. “It may be that the canine gut microbiota is better able to provide colonization resistance against C difficile, even when in an...
“It is unclear why pets appear to only infrequently acquire C difficile from their owners,” researchers wrote. “It may be that the canine gut microbiota is better able to provide colonization resistance against C difficile, even when in an...
“It is unclear why pets appear...
09/26/2023
First Report Managed Care
News
Addressing Multiple Negatives During Clostridioides difficile Testing
09/20/2023
Insights are shared from a case report of a patient with multiple negative tests for Clostridioides difficile infection, despite presenting with severe colitis, highlighting the challenges in diagnosing and treating C difficile infections.
Insights are shared from a case report of a patient with multiple negative tests for Clostridioides difficile infection, despite presenting with severe colitis, highlighting the challenges in diagnosing and treating C difficile infections.
Insights are shared from a case...
09/20/2023
First Report Managed Care
News
CDI Associated With Worse Outcomes After Certain Surgical Procedures
09/15/2023
Clostridioides difficile infection (CDI) after surgery is differentially associated with hospital length of stay, costs, readmissions, and mortality across specific procedures in US patients, according to a study published in the journal...
Clostridioides difficile infection (CDI) after surgery is differentially associated with hospital length of stay, costs, readmissions, and mortality across specific procedures in US patients, according to a study published in the journal...
Clostridioides difficile...
09/15/2023
First Report Managed Care
News
Patient-Reported Outcomes Drive Value-Based Care in Multiple Sclerosis
01/13/2025
A recent study published in Journal of Managed Care & Specialty Pharmacy explored multiple sclerosis (MS) as a compelling therapeutic area for outcomes-based agreements (OBAs) by assessing the use of patient-reported disability progression to...
A recent study published in Journal of Managed Care & Specialty Pharmacy explored multiple sclerosis (MS) as a compelling therapeutic area for outcomes-based agreements (OBAs) by assessing the use of patient-reported disability progression to...
A recent study published in...
01/13/2025
First Report Managed Care
News
Study Highlights the Substantial Economic and Health Care Burden of Vitiligo
01/13/2025
Patients with vitiligo in the US face significantly higher health care costs and resource utilization compared with the general population, according to a study published in the Journal of Investigative Dermatology.
Patients with vitiligo in the US face significantly higher health care costs and resource utilization compared with the general population, according to a study published in the Journal of Investigative Dermatology.
Patients with vitiligo in the US...
01/13/2025
First Report Managed Care
News
Biosimilars Expand Access and Cut Costs in HER2-Positive Cancer Treatment
01/10/2025
Biosimilar versions of trastuzumab have rapidly gained market share in treating HER2-positive breast cancer since their introduction to the US markets.
Biosimilar versions of trastuzumab have rapidly gained market share in treating HER2-positive breast cancer since their introduction to the US markets.
Biosimilar versions of...
01/10/2025
First Report Managed Care
News
COVID-19 Infection Linked to Increased Risk of Skin Conditions
01/08/2025
A recent study found that COVID-19 infection significantly increases the risk of developing skin conditions such as vitiligo, chronic urticaria, alopecia areata, and herpes zoster.
A recent study found that COVID-19 infection significantly increases the risk of developing skin conditions such as vitiligo, chronic urticaria, alopecia areata, and herpes zoster.
A recent study found that...
01/08/2025
First Report Managed Care
News
Provider Perceptions of Biosimilar Use in Oncology Networks
01/03/2025
Research published in the Journal of the American Pharmacists Association examined provider perceptions of barriers to biosimilar use in a large oncology network, revealing low levels of perceived barriers and high utilization rates, with...
Research published in the Journal of the American Pharmacists Association examined provider perceptions of barriers to biosimilar use in a large oncology network, revealing low levels of perceived barriers and high utilization rates, with...
Research published in the...
01/03/2025
First Report Managed Care
News
Study Suggests Cognitive Impairment More Likely With Late-Onset Multiple Sclerosis
12/19/2024
Patients with late-onset multiple sclerosis (MS) performed worse on most classic and social cognitive domains than patients with adult-onset MS after accounting for patient age and disease duration.
Patients with late-onset multiple sclerosis (MS) performed worse on most classic and social cognitive domains than patients with adult-onset MS after accounting for patient age and disease duration.
Patients with late-onset...
12/19/2024
First Report Managed Care
News
Evaluating Long-Term Cost Benefits of Etranacogene Dezaparvovec in Hemophilia B Management
12/19/2024
A study published in Journal of Managed Care and Specialty Pharmacy evaluated the budgetary implications of introducing etranacogene dezaparvovec, a novel gene therapy for hemophilia B, into a US commercial health plan.
A study published in Journal of Managed Care and Specialty Pharmacy evaluated the budgetary implications of introducing etranacogene dezaparvovec, a novel gene therapy for hemophilia B, into a US commercial health plan.
A study published in Journal of...
12/19/2024
First Report Managed Care
News
Financial Hardships Associated With Long COVID Across Income and Education Levels
12/19/2024
A study published in Health Services Research analyzing data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS) has revealed a significant association between long COVID and financial hardships.
A study published in Health Services Research analyzing data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS) has revealed a significant association between long COVID and financial hardships.
A study published in Health...
12/19/2024
First Report Managed Care
News
Oncology Biosimilars Offer Cost-Efficient Solutions for Sustainable Health Care
12/19/2024
Oncology biosimilars have emerged as a cost-effective and affordable alternative to their reference biologics.
Oncology biosimilars have emerged as a cost-effective and affordable alternative to their reference biologics.
Oncology biosimilars have...
12/19/2024
First Report Managed Care
News
Global Oncology Biosimilars Market to Surge to $35.79 Billion by 2034
12/19/2024
The global oncology biosimilars market is set to experience remarkable growth, with its value projected to soar from $6.50 billion in 2024 to $35.79 billion by 2034, at an impressive CAGR of 18.6%.
The global oncology biosimilars market is set to experience remarkable growth, with its value projected to soar from $6.50 billion in 2024 to $35.79 billion by 2034, at an impressive CAGR of 18.6%.
The global oncology biosimilars...
12/19/2024
First Report Managed Care

Insights

alpesh amin
Podcasts
How Does CDI Impact Health Care Utilization, Costs in Older Patients?
10/23/2023
Alpesh Amin, MD, MBA , professor and chair, University of California, discusses the results of a recent study, and explains why better treatments to reduce primary C difficile infection and recurrences in older adults can lower the mortality...
Alpesh Amin, MD, MBA , professor and chair, University of California, discusses the results of a recent study, and explains why better treatments to reduce primary C difficile infection and recurrences in older adults can lower the mortality...
Alpesh Amin, MD, MBA , professor...
10/23/2023
First Report Managed Care
gil melmed md gastrolenterologst
Podcasts
Understanding the Indirect, Direct Costs Linked With Recurrent Clostridioides difficile
09/23/2021
According to Gil Melmed, MD, gastroenterologist, recurrent CDI is multifactorial, and when estimating the burden of this condition, both direct and indirect costs should be considered.
According to Gil Melmed, MD, gastroenterologist, recurrent CDI is multifactorial, and when estimating the burden of this condition, both direct and indirect costs should be considered.
According to Gil Melmed, MD,...
09/23/2021
First Report Managed Care
Gil Melmed, MD
Podcasts
Costs, Utilization Linked With Recurrent Clostridioides difficile Infection
06/30/2021
Gil Melmed, MD, gastroenterologist, discusses recurrence rates among patients with Clostridioides difficile infection, and breaks down the treatment challenges, high costs, and higher health care utilization this patient population often...
Gil Melmed, MD, gastroenterologist, discusses recurrence rates among patients with Clostridioides difficile infection, and breaks down the treatment challenges, high costs, and higher health care utilization this patient population often...
Gil Melmed, MD,...
06/30/2021
First Report Managed Care
Headshot of Dr Gil Melmed on a blue background underneath the PopHealth Perspectives logo.
Podcasts
Bringing Awareness to Clostridioides difficile and Reviewing the Typical Treatment Regimen
06/01/2021
In an effort to bring more awareness to Clostridioides difficile, Gil Melmed, MD, gastroenterologist, Cedars Sinai, Los Angeles, breaks down the typical treatment regimen for this patient population, reviews treatment guidelines, and...
In an effort to bring more awareness to Clostridioides difficile, Gil Melmed, MD, gastroenterologist, Cedars Sinai, Los Angeles, breaks down the typical treatment regimen for this patient population, reviews treatment guidelines, and...
In an effort to bring more...
06/01/2021
First Report Managed Care
Headshots
Commentary
How to Maximize the Value of GLP-1 Drugs While Improving Health Equity
01/14/2025
GLP-1 drugs present significant financial and health equity challenges, offering transformative benefits for obesity and cardiometabolic disorders while requiring data-driven strategies for cost-effective and equitable access.
GLP-1 drugs present significant financial and health equity challenges, offering transformative benefits for obesity and cardiometabolic disorders while requiring data-driven strategies for cost-effective and equitable access.
GLP-1 drugs present significant...
01/14/2025
First Report Managed Care
Formoso Headshot
Videos
Minimally Invasive Solutions for Lumbar Disc Herniation
01/07/2025
In this interview, Ferdinand Formoso, DO, discusses the role of condoliase as a minimally invasive treatment for lumbar disc herniation, its safety profile, potential areas for further research, and its ability to address unmet needs in spine...
In this interview, Ferdinand Formoso, DO, discusses the role of condoliase as a minimally invasive treatment for lumbar disc herniation, its safety profile, potential areas for further research, and its ability to address unmet needs in spine...
In this interview, Ferdinand...
01/07/2025
First Report Managed Care
DeMarrais Headshot
Commentary
How Health Systems Can Meet the Expanding Needs of Specialty Pharmacies
01/03/2025
Health systems must adapt to the growing demand for specialty pharmacies by scaling services, embracing technology, and collaborating with experts to improve patient outcomes, reduce administrative burdens, and navigate regulatory challenges.
Health systems must adapt to the growing demand for specialty pharmacies by scaling services, embracing technology, and collaborating with experts to improve patient outcomes, reduce administrative burdens, and navigate regulatory challenges.
Health systems must adapt to the...
01/03/2025
First Report Managed Care
Varshney Headshot
Interview
Transforming Drug Development Through Real-World Evidence and Artificial Intelligence
01/03/2025
In this interview, Dr Jo Varshney, founder and CEO of VeriSIM Life, discusses the complexities of drug development, the role of AI in accelerating discovery, the integration of real-world evidence, and strategies to reduce costs while...
In this interview, Dr Jo Varshney, founder and CEO of VeriSIM Life, discusses the complexities of drug development, the role of AI in accelerating discovery, the integration of real-world evidence, and strategies to reduce costs while...
In this interview, Dr Jo...
01/03/2025
First Report Managed Care
KOL Headshots
Commentary
2024 Trends and 2025 Predictions: Insights From Health Care Leaders on Advancing Medicare, AI Solutions, and Clinical Data Utilization
12/27/2024
In this exclusive commentary for First Report Managed Care, health experts and business leaders explore how advancements in Medicare Advantage, ambient intelligence, generative AI, cybersecurity, risk adjustment, precision oncology, and AI...
In this exclusive commentary for First Report Managed Care, health experts and business leaders explore how advancements in Medicare Advantage, ambient intelligence, generative AI, cybersecurity, risk adjustment, precision oncology, and AI...
In this exclusive commentary for...
12/27/2024
First Report Managed Care
Kolodziej Headshot
Videos
Navigating Biosimilar Adoption: Lessons from Global Markets and Clinical Practices
12/20/2024
In this interview, Michael Kolodziej, MD, discusses strategies for enhancing biosimilar adoption in the US, emphasizing lessons from global markets, the importance of payer flexibility, and the need for collaboration to reduce costs and...
In this interview, Michael Kolodziej, MD, discusses strategies for enhancing biosimilar adoption in the US, emphasizing lessons from global markets, the importance of payer flexibility, and the need for collaboration to reduce costs and...
In this interview, Michael...
12/20/2024
First Report Managed Care
Mike Kolodziej, MD
Videos
Exploring Biosimilar Adoption and Policy Impacts in Oncology
12/18/2024
In this interview, Michael Kolodziej, MD, discusses the role of biosimilars in value-based care models, their relationship with targeted therapies, and the impact of policy changes and market trends on biosimilar adoption and cost...
In this interview, Michael Kolodziej, MD, discusses the role of biosimilars in value-based care models, their relationship with targeted therapies, and the impact of policy changes and market trends on biosimilar adoption and cost...
In this interview, Michael...
12/18/2024
First Report Managed Care
Robbins
Podcasts
Improving Access to CGRP Therapies for Effective Migraine Treatment
12/12/2024
Explore the challenges patients face in accessing CGRP therapies for migraines, strategies to streamline treatment effectiveness, and the crucial role of health care providers in navigating access barriers and aligning clinical guidelines...
Explore the challenges patients face in accessing CGRP therapies for migraines, strategies to streamline treatment effectiveness, and the crucial role of health care providers in navigating access barriers and aligning clinical guidelines...
Explore the challenges patients...
12/12/2024
First Report Managed Care
Hennessy Headshot
Videos
Navigating Biosimilar Integration: Cost Savings, Coverage, and Future Strategies for Payers
12/10/2024
John Hennessy, MBA, discusses the complexities of biosimilar adoption, highlighting potential cost savings, payer strategies, challenges in provider and patient acceptance, regulatory impacts, and the critical need for sustainable market...
John Hennessy, MBA, discusses the complexities of biosimilar adoption, highlighting potential cost savings, payer strategies, challenges in provider and patient acceptance, regulatory impacts, and the critical need for sustainable market...
John Hennessy, MBA, discusses...
12/10/2024
First Report Managed Care
Interview
Nontraditional Players in Health Care Highlight the Need to Balance Quality and Cost-Effectiveness With Convenience and Accessibility
12/03/2024
In this interview, Dr Lucienne Ide discusses the challenges nontraditional players face in health care, the critical role of trust, and the need for innovative, collaborative solutions to improve access, outcomes, and cost-effectiveness.
In this interview, Dr Lucienne Ide discusses the challenges nontraditional players face in health care, the critical role of trust, and the need for innovative, collaborative solutions to improve access, outcomes, and cost-effectiveness.
In this interview, Dr Lucienne...
12/03/2024
First Report Managed Care
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