Introduction: The presence of microorganisms, development of biofilm, and local infection play a significant role in the pathogenesis of hard-to-heal wounds. Systemic antimicrobial therap...
Introduction: The immune system is central to progressing an injury through the wound healing cascade. However, comorbidities often lead to dysregulation of the inflammatory response and ...
Introduction: While Silver is widely regarded as an effective antimicrobial agent it can be cytotoxic to fibroblast and keratinocytes, and the reported antibacterial effects of silver are...
Introduction: It is well known that pH controlled, mildly acidic pure Hypochlorous Acid (pHA) based cleansers produce visibly clean wounds, that also can be shown to have lower bioburden ...
Introduction: Various processing techniques are utilized to manufacture placental allografts, including cryopreservation, dehydration, lyophilization, and hypothermic storage. Processing ...
Introduction: The clinical use of pure hypochlorous acid(pHA/HOCl)-based wound cleansers has gained widespread adoption for a number of reasons, such as their mildly acidic nature, they e...
Introduction: Decellularized extracellular matrix (ECM) medical devices can facilitate healing of hard-to-heal wounds by acting as a scaffold. A novel decellularized porcine placental ECM...
Introduction:
Our previous studies have shown that oat-derived bioactives avenanthramide (AVE) and beta-glucan (βG) stimulate endothelial proliferation in vitro, angiogenesis and endothe...
Introduction: Aplicor 3D is a novel FDA-cleared 3D printer that uses autologous human adipose to create patient-specific wound coverings. Solidifying the soft adipose tissue into a graft ...
Introduction: Hard-to-heal wounds pose a significant clinical challenge, resulting in poor patient quality of life and substantial economic burden. Polymicrobial communities within hard-t...