Analysis Shows High Rates of Patient Satisfaction With Secukinumab for Plaque Psoriasis

A real-world analysis of patients with plaque psoriasis found a high level of sustained satisfaction with secukinumab for improving skin clearance. Researchers published their findings online ahead of print in Dermatology and Therapy.

“In this analysis of deidentified electronic medical record data from patients with predominantly moderate-to-severe plaque psoriasis, patients achieved and maintained a high level of treatment satisfaction with secukinumab up to 24 months, regardless of previous treatment experience,” researchers wrote.

The study, funded by Novartis Pharmaceuticals Corporation, included adults with plaque psoriasis treated with secukinumab between March 1, 2018, and January 1, 2020.

In all, 82.3% of patients thought secukinumab was effective in clearing their skin at 6 months. Throughout the 24-month marker, satisfaction with secukinumab stayed above 81%, according to the study. Results were similar for patient subsets with various levels of prior treatment experience.

Among patients not initially satisfied with secukinumab, most of whom were treatment-naive, 77.9% were satisfied after 6 months of treatment, 74.4% at 12 months, 82.8% at 18 months, and 71.4% at 24 months.

The study also found meaningful changes with secukinumab in percent affected body surface area and Physician Global Assessment scores through 24 months of treatment.

“These findings support data from randomized controlled trials and highlight the sustained real-world satisfaction with secukinumab in clearing the skin of psoriasis,” researchers wrote. “Further research is needed to supplement current findings and assess additional determinants of treatment satisfaction beyond achievement of clear skin, with complete data on confirmed filled prescription of biologics and consistent effectiveness measures over an extended time period.”

Reference:
Armstrong AW, Patil D, Levi E, et al. Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24 Months of Follow-Up: Results from US Dermatology Electronic Medical Records [published online ahead of print, 2021 Aug 28]. Dermatol Ther (Heidelb). 2021;10.1007/s13555-021-00599-5. doi:10.1007/s13555-021-00599-5