Dandan Chen, MD, PhD

Effects of Solriamfetol on Driving Performance in Participants With Narcolepsy

Introduction: Solriamfetol, a dopamine/norepinephrine reuptake inhibitor, is approved in the US and EU to improve wakefulness in adults with excessive daytime sleepiness (EDS) associated ...

Dandan Chen , MD, PhD;

Frederick Vinckenbosch , MSc;

Gert Jan Lammers , PhD, MD;

Sebastiaan Overeem , MD, PhD;

Grace Wang , MD, MS;

Lawrence Carter , PhD;

Kefei Zhou , PhD;

Johannes Ramaekers , PhD;

Annemiek Vermeeren , PhD;

10/08/2020

Effects of Solriamfetol on Driving Performance in Participants With Excessive Daytime Sleepiness Associated With Obstructive Sleep Apnea

Introduction: Solriamfetol, a dopamine/norepinephrine reuptake inhibitor, is approved (US and EU) to treat excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA;...

Johannes Ramaekers , PhD;

Annemiek Vermeeren , PhD;

Jerryll Asin , MD;

Nicolaas de Vries , MD, PhD;

Patty Vonk , MD;

Claire Donjacour , MD, PhD;

Hennie Janssen , MD, PhD;

Dandan Chen , MD, PhD;

Frederick Vinckenbosch , MSc;

Gert Jan Lammers , PhD, MD;

Sebastiaan Overeem , MD, PhD;

Grace Wang , MD, MS;

Lawrence Carter , PhD;

Kefei Zhou , PhD;

10/08/2020

Challenges and Considerations in Design of a Placebo-Controlled, Double-Blind, Randomized-Withdrawal Study Evaluating the Efficacy and Safety of JZP-258 for the Treatment of Idiopathic Hypersomnia

No treatment is approved for idiopathic hypersomnia (IH). A retrospective chart review (Leu-Semenescu, et al. Sleep Med. 2016;17:38-44) demonstrated effectiveness of sodium oxybate (SXB) ...

Patricia Chandler , MD;

Dandan Chen , MD, PhD;

Judith Profant , PhD, MS;

Amanda Sterkel , PhD;

Yves Dauvilliers , MD, PhD;

10/08/2020

Pooled Analysis From 12-Week Randomized, Controlled Studies of Solriamfetol in the Treatment of Excessive Daytime Sleepiness in Participants With Obstructive Sleep Apnea or Narcolepsy

Background: Solriamfetol (formerly JZP-110), a dopamine and norepinephrine reuptake inhibitor, has been approved in the US (SunosiTM) to improve wakefulness in adults with excessive dayti...

Colin Shapiro , PhD, FRCPC, MBBCh;

Michelle Baladi , PhD;

Dandan Chen , MD, PhD;

Helene Emsellem , MD;

Michael Thorpy , MD, CHBC;

Kris Liu , PhD;

Paula Schweitzer , MD, PhD;

Kimberly Babson , PhD;

11/22/2019

Quality of Life, Functional Evaluation, and Work Productivity in Patients With Narcolepsy: Results From a Phase 3 Study of Solriamfetol (JZP-110)

INTRODUCTION: Solriamfetol, a selective dopamine/norepinephrine reuptake inhibitor, significantly decreased excessive sleepiness in a randomized, double-blind, placebo-controlled study of...

Michael Thorpy , MD, CHBC;

Giuseppe Plazzi , MD;

Yves Dauvilliers , MD, PhD;

Colin Shapiro , PhD, FRCPC, MBBCh;

Jed Black , MD;

Geert Mayer , MD;

Helene Emsellem , MD;

Dandan Chen , MD, PhD;

Robert Ryan , MS;

Gert Jan Lammers , PhD, MD;

Chevy Chase , MD;

Lawrence Carter , PhD;

03/01/2019

Case Report

Right Atrial Thrombus in Transit

12/28/2020

Rajesh Sachdeva , MD;

Dandan Chen , MD, PhD;

Gautam Kumar , MD, FSCAI;

An 84-year-old woman was brought to the emergency room with lightheadedness and shortness of breath that had started 3 days earlier. She had a past medical history of paroxysmal atrial fibrillation, hypertension, and coronary artery disease.

An 84-year-old woman was brought...

12/28/2020

Cath Lab Digest