Sara Lonardi

Background In the phase 2 multicohort CheckMate 142 study (NCT02060188), nivolumab plus low-dose (1 mg/kg) ipilimumab provided robust and durable clinical benefit with a manageable safety...

S. Abdullaev ;

A. Memaj ;

M. Lei ;

Scott Kopetz , MD, PhD;

M. Overman ;

A. Hill ;

K. Wong ;

T. Andre ;

Eric Van Cutsem , MD, PhD;

Sara Lonardi ;

H. Lenz ;

F. Gelsomino ;

M. Aglietta ;

M. Morse ;

Ryan M. McDermott ;

M. Sawyer ;

A. Hendlisz ;

B. Neyns ;

07/02/2021

A phase 3 study of nivolumab (NIVO), NIVO + ipilimumab (IPI), or chemotherapy for microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) metastatic colorectal cancer (mCRC): CheckMate 8HW

Background Patients with MSI-H/dMMR mCRC treated with chemotherapy have poorer outcomes than patients with microsatellite stable/MMR proficient mCRC. Pembrolizumab monot...

T. Andre ;

Sara Lonardi ;

S. Abdullaev ;

M. Lei ;

L. Jensen ;

C. De la Fouchardiere ;

E. Elez ;

J. Bennouna ;

G. Mendez ;

J. Li ;

Eric Van Cutsem , MD, PhD;

E. Goekkurt ;

T. Chen ;

Takayuki Yoshino , MD, PhD;

06/27/2022

FOLFOXIRI plus bevacizumab and atezolizumab as upfront treatment of unresectable mCRC patients: Updated and overall survival results of the phase II randomized AtezoTRIBE study

AtezoTRIBE (NCT03721653) is a phase II randomized trial in which unresectable mCRC pts were randomized 1:2 to 1st-line FOLFOXIRI/bev [arm A] or FOLFOXIRI/bev/atezo [arm B]. Adding atezo t...

S. Tamberi ;

M. Bensi ;

I. Toma ;

M. De Grandis ;

M. Palermo ;

A. Cappetta ;

Sara Lonardi ;

A. Catteau ;

C. Antoniotti ;

L. Boni ;

F. Marmorino ;

J. Galon ;

V. Conca ;

R. Moretto ;

Filippo Pietrantonio ;

C. Cremolini ;

A. Passardi ;

M. Ambrosini ;

L. Salvatore ;

06/25/2023

Predictive impact of RNF43 mutation (mut) in pMMR/MSS BRAFV600E-mutated metastatic colorectal cancer (mCRC) patients (pts) treated with target therapy (TT) or chemotherapy (CT)

Encorafenib plus cetuximab is a standard option in the treatment of BRAFV600E mut mCRC pts pre-treated with at least one systemic therapy. RNF43 is a negative regulator of WNT pathway. A ...

Guglielmo Vetere ;

G. Fontanini ;

Rodrigo De Almeida Toledo ;

F. Bergamo ;

Giovanni Randon , MD;

Simone Oldani ;

Walter Ferrari Bravo ;

Gianmarco Ricagno ;

Paola Vignali ;

Sara Lonardi ;

E. Elez ;

R. Moretto ;

M. Germani ;

M. Giordano ;

Rossana Intini ;

C. Cremolini ;

Filippo Ghelardi ;

C. Ugolini ;

06/25/2023

Sara Lonardi, MD, Veneto Institute of Oncology

Videos

Using Liquid Biopsy to Guide Post-Surgical Treatment Among Patients With Colon Cancer

11/16/2023

Sara Lonardi ;

Sara Lonardi, MD, shares results from the PEGASUS trial which found post-surgical liquid biopsy may be used to guide the clinical management of patients with high-risk stage II or stage III colon cancer.

Sara Lonardi, MD, shares results...

11/16/2023

Oncology

Tumor mutational load, microsatellite instability, BRCAness, and actionable alterations in metastatic colorectal cancer: Results from the TRIBE2 study

Background In the TRIBE2 study, molecularly unselected and untreated mCRC patients were randomized to receive FOLFOXIRI/bevacizumab (bev) followed by the same agents after disease progres...

T. Latiano ;

E. Tamburini ;

A. Passardi ;

Sara Lonardi ;

D. Santini ;

H. Lenz ;

A. Zaniboni ;

C. Antoniotti ;

G. Aprile ;

F. Marmorino ;

R. Bordonaro ;

G. Zucchelli ;