Otto M. Hess, MD, PhD

Original Contribution

Polymer Stent Coating for Prevention of Neointimal Hyperplasia

08/01/2008

Felix Buddeberg , MD;

Jeffrey A. Hubbell , PhD;

Bernhard Meier , MD, FACC, FESC;

Donald L. Elbert , PhD;

Stephan Windecker , MD;

Daniel Mettler , DVM;

Thomas Schaffner , MD;

Michael Billinger , MD;

Otto M. Hess , MD, PhD;

Attempts to reduce neointimal proliferation following coronary artery stent implantation have focused on stent coatings with or without local drug delivery. Polymers provide some unique features, which determine their use as coating material:...

Attempts to reduce neointimal...

08/01/2008

Journal of Invasive Cardiology

Original Contribution

Endothelialization of Sirolimus-Eluting Stents with Slow and Extended Drug Release in the Porcine Overstretch Model

12/01/2008

Daniela Frey , BA;

Michael Billinger , MD;

Pascal Meier , MD;

Olgica Beslac , RN;

Raphael Grossenbacher , RN;

Otto M. Hess , MD, PhD;

ABSTRACT: Background. Vascular healing of intracoronary stents has been shown to be delayed in drug-eluting stents (DES) due to the cytotoxic compounds on the stent surface that prevent stent ingrowth and endothelialization. The lack of...

ABSTRACT: Background. Vascular...

12/01/2008

Journal of Invasive Cardiology

Original Contribution

Intimal Proliferation and Restenosis in Paclitaxel-Eluting Stents with Aminoparylene as Carrier Substance in Swines

03/10/2009

Otto M. Hess , MD, PhD;

From the *Division of Cardiology, Swiss Cardiovascular Center, Bern, and the §Institute of Pathology, University Hospital Bern, Switzerland. Disclosures: This study was funded with an unrestricted educational grant from Fumedica AG,...

From the *Division of...

03/10/2009

Journal of Invasive Cardiology

Original Contribution

Pooled Analysis of Trials Comparing Titanium-Nitride-Oxide-Coated Stents with Paclitaxel-Eluting Stents in Patients Undergoing

07/06/2010

Juhani K.E. Airaksinen , MD, PhD, FESC;

Fausto Biancari , MD, PhD;

Lorentz Raeber , MD;

Antti Ylitalo , MD, PhD;

Michael Billinger , MD;

Pasi P. Karjalainen , MD, PhD;

Otto M. Hess , MD, PhD;

ABSTRACT: We performed a pooled analysis of three trials comparing titanium-nitride-oxide-coated bioactive stents (BAS) with paclitaxel-eluting stents (PES) in 1,774 patients. All patients were followed for 12 months. The primary outcomes...

ABSTRACT: We performed a...

07/06/2010

Journal of Invasive Cardiology

Original Contribution

Endothelial-Cell-Binding Aptamer for Coating of Intracoronary Stents

10/07/2010

Michael Billinger , MD;

Pascal Meier , MD;

Otto M. Hess , MD, PhD;

Yvonne Strahm , BA;

Annina Flueckiger , BA;

Daniel Mettler , DVM;

Susan Weisser , RN;

Thomas Schaffner , MD;

ABSTRACT: Oligonucleotides capturing CD31 endothelial cells (= aptamer) were used for coating of intracoronary stents to improve endothelialization and vascular healing. Methods. Three different coronary stents were implanted in 9 farm-raised...

ABSTRACT: Oligonucleotides...

10/07/2010

Journal of Invasive Cardiology