Case Series

The Use of Novel New Multi-tissue Biomaterial Powder Focused on Cell Signaling in Wound Healing Applications: A Case Series

10/17/2018

BACKGROUND: Physicians are always on the lookout for new products to aid in healing challenging and difficult wounds. A new multi-tissue biomaterial powder has been evaluated in a variety of different wounds in this case series.

This wound powder was developed to take advantage of the signaling components and biomolecules that are present in naturally derived tissue-based constructs. The product is a composition of spleen and lung extracellular matrix material. This material facilitates the repair and regeneration of damaged tissue by inducing the body’s own regenerative capabilities. More specifically, the material works by recruiting stem cells to the implant site, modulating the body’s inflammatory response to that of a regenerative response, and inducing angiogenesis.

This wound powder is distinguished from other tissue products in several ways. It is derived from 2 tissue sources instead of 1, which allows for a more diverse mix of components. Other products are about 90% collagen, while this new biomaterial is 45% collagen, 25% elastin, 14% fibronectin, and 7% laminin. This is important because it provides a much more diverse mix of potential binding sites and signaling components. Multiple collagen types have been identified in the material including collagen types I, III, IV, and V. Hyaluronic acid, glycosaminoglycans, lipids, and growth factors also have been identified in the material. The growth factors investigated to date demonstrate the presence of fibroblast growth factor, vascular endothelial growth factor, and epidermal growth factor.

METHODS/RESULTS: A variety of cases including failed amputation, delayed healing of a postoperative squamous cell carcinoma, and chronic diabetic foot ulcers are included. All patients healed within 6 weeks following appropriate wound care and application of this new wound powder.

CONCLUSIONS: This new powder shows great promise treating a variety of wounds.

CITATION
Kimmel H. The use of novel new multi-tissue biomaterial powder focused on cell signaling, in wound healing applications: a case series. Poster presented at: Symposium on Advanced Wound Care Fall; November 2-4, 2018; Las Vegas, NV.

Product: XCelliStem, Stemsys (Fort Lauderdale, FL)

This abstract was not subject to the WOUNDS peer-review process.

Understanding Diabetic Induction of Cellular Senescence: A Concise Review

Efficacy of a New Flowable Wound Matrix in Tunneled and Cavity Ulcers: A Preliminary Report