RE: A literature review of pharmacological agents to improve venous leg ulcer healing

Dear Drs Melin and Dean:

Thank you for your feedback and appreciation toward the publication of our July 2020 article with Wounds¹ in your November 2020 Letter to the Editor.²
It was our goal to bring to light the different types of pharmaceuticals available for clinicians treating venous leg ulcers. It is good to know that our work can be augmented, and that people are reading it. Our goal is to stimulate more placebo-controlled trials and level 1 evidence to this matter. We applaud your efforts for the extensive research on Vasculera and micronized purified flavonoid fraction (MPFF). We thank the doctors for their thoughtful reply and sharing these comments.

The current literature on microflavonoids you proffer can only act as a positive adjunct to our manuscript. We appreciate your well-researched addition to our work; this can only add benefit as clinicians consider using these therapies. As you state, Vasculera as an MPFF should indeed fall under the drug classification and labeled ‘YES’ for therapeutic recommendations.² We agree that medical foods do in fact have therapeutic medicinal benefits that positively impact diseases and pathology. In the future, we believe medical foods will play a larger role and concur that accuracy in these descriptions, discussions, and data evaluation are important deciders to provider education and consideration.

Sincerely,

Brandon Kitchens, DPM, MBA;
Robert J. Snyder, DPM, MBA, MSc, CWSP, FFPM RCPS (Glasg); and
Cherison A. Cuffy, DPM, CWSP

Note: This article was not subject to WOUNDS peer-review process. 

References

1. Kitchens BP, Snyder RJ, Cuffy CA. A literature review of pharmacological agents to improve venous leg ulcer healing. Wounds. 2020;32(7):195–207.

2. Melin MM, Dean SM. RE: A literature review of pharmacological agents to improve venous leg ulcer healing. Wounds. 2020;32(11):A10.