The Use of an Autologous Blood Clot, in hard to heal Wounds – A Case Series Study

Introduction: Managing hard to heal wounds, especially in patients with comorbidities, are both challenging and associated with high treatment costs.
ActiGraft (RedDress Ltd.), is an autologous, biodegradable scaffold, which recreates the functional wound healing environment and promotes the wound healing process1. ActiGraft was found to be highly effective in various of wound types in a post marketing study, regardless to the patients’ comorbidities.
This abstract reports several cases of high interest from this study.
 
Objectives: Demonstrate ActiGraft efficacy in healing hard to heal wounds from different etiologies.

Nine hard to heal wounds were treated with ActiGraft applications.  Cases were followed by digital photography and data collection in a real-life usage, with no definition of inclusion exclusion criteria. The trial was approved by a central Institutional Review Board and conducted in wound care clinics across the USA and Israel.

Nine wounds with multiple failure of other treatments, were subjected to ActiGraft treatment: 1 failed trans-metatarsal amputation, 2 diabetic ulcers, 1 Below knee amputation with failure to muscle flap ulcer, 2 diabetic ulcers on Charcot Foots, 1 pressure ulcer on the buttock, 1 post Cutaneous Squamous Cell Carcinoma operation dehiscence ulcer, and 1 radiation ulcer. All patients suffered from severe comorbidities. Treatment frequency diverse between patients, until complete healing was achieved.  Wound area at baseline ranged between 1.7cm2 and 129cm2.All wounds were completely healed within 1 week to 8 weeks with the use of ActiGraft.

ActiGraft treatment showed high efficacy with healing complex wounds including exposed bones, amputation salvage and severely impaired wound healing. The potential of bringing an affordable cost saving advanced biologic bedside treatment, which is highly effective in various types of wounds, presents a possibility of new solution to complex cases.

Trademarked Items (if applicable):

References (if applicable): 1. Kushnir I, Serena T, Garfinkel D, Efficacy and Safety of a Novel Autologous Wound Matrix in the Management of Complicated, Chronic Wounds: A Pilot Study. WOUNDS ;28(9):317-327.