Lower Extremity Wounds Treated Using A Synthetic Nanofiber Matrix*

Lower extremity wounds, including diabetic foot ulcers, venous leg ulcers, and surgical wounds, can be difficult to heal and may benefit from the use of an advanced treatment modality. This four-patient case series describes the use of a synthetic nanofiber matrix* for lower extremity wounds refractory to various treatments [1].
In the first case, a 70-year-old female with scleroderma and a recurrent squamous cell carcinoma presented with a wound that was over 30 years old that had failed previous treatments, including skin grafts. The wound was treated with the synthetic nanofiber matrix* in conjunction with hyperbaric oxygen therapy and was completely re-epithelialized after 5 applications over 6 weeks.
In the second case, a 74-year-old male with type II diabetes and other co-morbidities presented with a chronic venous leg ulcer refractory to other treatment, including a collagen material and negative pressure wound therapy (NPWT). The wound was treated with the synthetic nanofiber matrix*, and the patient achieved full closure in 12 weeks with 4 applications.
In the third case, a 44-year-old male with type II diabetes and other co-morbidities underwent a left fifth toe and metatarsal head amputation. The wound was originally treated with NPWT but then discontinued. The wound was then debrided and treated with the synthetic nanofiber matrix*. After 5 applications over 11 weeks, the wound was completely healed.
In the fourth case, a 55-year-old male with type II diabetes and other co-morbidities underwent a transmetatarsal amputation. The wound was treated with hyperbaric oxygen therapy and then treated with the synthetic nanofiber matrix*. The wound demonstrated significant healing over 14 weeks of treatment with the material.
The successful clinical use of the synthetic nanofiber matrix* observed in these cases supports the use of this material for the treatment of complex lower extremity wounds refractory to existing therapies.

Trademarked Items (if applicable): *Restrata®, Acera Surgical, Inc., St. Louis, MO

References (if applicable): 1. MacEwan MR, MacEwan S, Kovacs TR, Batts J. What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold. Cureus 2017. 9(10): e1736.