Assessing the antibiofilm properties of a new Ionic Silver dressing

A new dressing has been developed containing an ionic silver compound as the active ingredient for its antibacterial properties.  The product currently demonstrates excellent antibacterial activity against a broad spectrum of common wound isolates under clinical conditions based on log reduction testing.  An emerging aspect of research with regard to chronic wounds, especially in the era of antibiotic resistance, includes biofilm management; therefore, the potential of a dressing to exhibit antibiofilm properties requires investigating.

In vitro tests, developed in house, were performed using clinically relevant wound microorganisms under clinical conditions in order to create surface attached biofilm to a substrate.  Both prevention and eradication of the biofilm was then determined by directly applying the Silver dressing and performing total viable counts (TVCs) following homogenisation at defined timepoints in order to evaluate the effect.

The data demonstrates that the novel Silver dressing is effective at disrupting an established biofilm as well as preventing a biofilm from forming, as the percentage recovered on the treated samples compared to the negative controls were substantially lower.  Challenging these biofilm properties are pivotal in wound healing and the prevention of chronic wound formation.

The in vitro testing has enabled the antibiofilm properties of the Silver dressing to be assessed with regards to prevention of biofilm formation as well as eradication, with the data indicating the product to perform significantly well.

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References (if applicable): Bowler, P. (2018). Antibiotic resistance and biofilm tolerance: a combined threat in the treatment of chronic infections. Journal of Wound Care, 27(5), pp.273-277