A recent research study, published in the Arteriosclerosis, Thrombosis, and Vascular Biology, set out to determine if psoriasis is associated with abdominal aortic aneurysm, a complex multifactorial disease associated with a high morbidity and mortality.
Khalid et al evaluated data from a registry of all Danish residents aged ≥18 years followed up from January 1, 1997, until diagnosis of AAA, December 31, 2011, migration or death. During the study period, the researchers identified 59,423 patients with mild psoriasis and 11,566 patients with severe psoriasis.
Comorbidity, concomitant medication, and socioeconomic status information was identified by individual-level linkage of administrative registers. Incidence rates for AAA were calculated and incidence rate ratios adjusted for age, sex, comorbidity, medications, socioeconomic status, and smoking were estimated in Poisson regression models. A total of 5,495,203 subjects were eligible for analysis.
The results demonstrated that the overall incidence rates of AAA were 3.72, 7.30, and 9.87 per 10,000 person-years for the reference population (23,696 cases), mild psoriasis (240 cases), and severe psoriasis (50 cases), respectively. The corresponding adjusted incidence rate ratios for AAA were increased in patients with psoriasis with incidence rate ratios of 1.20 (95% confidence interval [CI], 1.03–1.39) and 1.67 (CI, 1.21–2.32) for subjects with mild and severe disease, respectively.
In the nationwide cohort, psoriasis was associated with a disease severity-dependent increased risk of AAA. The mechanisms and consequences of this novel finding require further investigation, concluded the researchers.
Reference
Usman Khalid, Alexander Egeberg, Ole Ahlehoff et al. Nationwide Study on the Risk of Abdominal Aortic Aneurysms in Patients With Psoriasis. Arteriosclerosis, Thrombosis, and Vascular Biology. Published on line a head of print April 14, 2016.
A recent research study, published in the Arteriosclerosis, Thrombosis, and Vascular Biology, set out to determine if psoriasis is associated with abdominal aortic aneurysm, a complex multifactorial disease associated with a high morbidity and mortality.
Khalid et al evaluated data from a registry of all Danish residents aged ≥18 years followed up from January 1, 1997, until diagnosis of AAA, December 31, 2011, migration or death. During the study period, the researchers identified 59,423 patients with mild psoriasis and 11,566 patients with severe psoriasis.
Comorbidity, concomitant medication, and socioeconomic status information was identified by individual-level linkage of administrative registers. Incidence rates for AAA were calculated and incidence rate ratios adjusted for age, sex, comorbidity, medications, socioeconomic status, and smoking were estimated in Poisson regression models. A total of 5,495,203 subjects were eligible for analysis.
The results demonstrated that the overall incidence rates of AAA were 3.72, 7.30, and 9.87 per 10,000 person-years for the reference population (23,696 cases), mild psoriasis (240 cases), and severe psoriasis (50 cases), respectively. The corresponding adjusted incidence rate ratios for AAA were increased in patients with psoriasis with incidence rate ratios of 1.20 (95% confidence interval [CI], 1.03–1.39) and 1.67 (CI, 1.21–2.32) for subjects with mild and severe disease, respectively.
In the nationwide cohort, psoriasis was associated with a disease severity-dependent increased risk of AAA. The mechanisms and consequences of this novel finding require further investigation, concluded the researchers.
Reference
Usman Khalid, Alexander Egeberg, Ole Ahlehoff et al. Nationwide Study on the Risk of Abdominal Aortic Aneurysms in Patients With Psoriasis. Arteriosclerosis, Thrombosis, and Vascular Biology. Published on line a head of print April 14, 2016.
A recent research study, published in the Arteriosclerosis, Thrombosis, and Vascular Biology, set out to determine if psoriasis is associated with abdominal aortic aneurysm, a complex multifactorial disease associated with a high morbidity and mortality.
Khalid et al evaluated data from a registry of all Danish residents aged ≥18 years followed up from January 1, 1997, until diagnosis of AAA, December 31, 2011, migration or death. During the study period, the researchers identified 59,423 patients with mild psoriasis and 11,566 patients with severe psoriasis.
Comorbidity, concomitant medication, and socioeconomic status information was identified by individual-level linkage of administrative registers. Incidence rates for AAA were calculated and incidence rate ratios adjusted for age, sex, comorbidity, medications, socioeconomic status, and smoking were estimated in Poisson regression models. A total of 5,495,203 subjects were eligible for analysis.
The results demonstrated that the overall incidence rates of AAA were 3.72, 7.30, and 9.87 per 10,000 person-years for the reference population (23,696 cases), mild psoriasis (240 cases), and severe psoriasis (50 cases), respectively. The corresponding adjusted incidence rate ratios for AAA were increased in patients with psoriasis with incidence rate ratios of 1.20 (95% confidence interval [CI], 1.03–1.39) and 1.67 (CI, 1.21–2.32) for subjects with mild and severe disease, respectively.
In the nationwide cohort, psoriasis was associated with a disease severity-dependent increased risk of AAA. The mechanisms and consequences of this novel finding require further investigation, concluded the researchers.
Reference
Usman Khalid, Alexander Egeberg, Ole Ahlehoff et al. Nationwide Study on the Risk of Abdominal Aortic Aneurysms in Patients With Psoriasis. Arteriosclerosis, Thrombosis, and Vascular Biology. Published on line a head of print April 14, 2016.
