A recent open label study,1 conducted between July and September 2012, examined microbial communities of patients with psoriasis vulgaris who were characterized prior and post a 3-week selenium-rich water balneotherapy treatment at the thermal care center in La Roche-Posay, France.
For the study, 54 patients diagnosed with moderate-to-severe forms of psoriasis vulgaris received balneotherapy, which consisted of high-pressure filiform showers, baths, facial, body spray treatments, and La Roche-Posay thermal spring water (LRP-TSW) consumption. Swabs were taken from affected and proximal unaffected skin and the 16S rRNA bacterial gene was used to analyze the composition of bacterial communities. Using the same 16S rRNA gene tool, the researchers described the LRP-TSW bacterial landscape.
After eliminating individuals lacking paired samples from both visits, 29 individuals were analyzed for their microbiome profile. Shannon Diversity Index and global bacterial landscape indicate similar microbial communities on both unaffected and adjacent affected skin. The researchers noted that Psoriasis Area and Severity Index values decreased post-balneotherapy, which implied improvement of disease severity. No significant change in the Shannon Diversity Index was noticed at the end of the third week.
In addition the average taxonomic composition of skin microbial communities associated with unaffected and affected skin of psoriatic patients post-balneotherapy, shows that treatment with LRP-TSW significantly increased the level of Xanthomonas genus and, to a lesser extent, Corynebacterium genus, they reported. The Xanthomonas genus belongs to the main Xanthomonadaceae family found in LRP-TSW and also on healthy skin.
The researchers concluded that in psoriatic patients, a poor bacterial biodiversity was noticed and the bacterial communities were similar on unaffected and affected adjacent skin. Family analysis identified, for the first time, Xanthomonadaceae belonging to Proteobacteria phylum and known to be keratolytic, associated with the clinical improvement observed after a 3-week balneotherapy treatment. This data supports the interest of selenium-rich thermal spring water in the treatment of psoriasis vulgaris, they added.
Reference
1. Martin R, Henley JB, Sarrazin P, Seite S. Skin microbiome in patients with psoriasis before and after balneotherapy at the thermal care center of La Roche-Posay. J Drugs Dermatol. 2015;14(12):1400-1405.
A recent open label study,1 conducted between July and September 2012, examined microbial communities of patients with psoriasis vulgaris who were characterized prior and post a 3-week selenium-rich water balneotherapy treatment at the thermal care center in La Roche-Posay, France.
For the study, 54 patients diagnosed with moderate-to-severe forms of psoriasis vulgaris received balneotherapy, which consisted of high-pressure filiform showers, baths, facial, body spray treatments, and La Roche-Posay thermal spring water (LRP-TSW) consumption. Swabs were taken from affected and proximal unaffected skin and the 16S rRNA bacterial gene was used to analyze the composition of bacterial communities. Using the same 16S rRNA gene tool, the researchers described the LRP-TSW bacterial landscape.
After eliminating individuals lacking paired samples from both visits, 29 individuals were analyzed for their microbiome profile. Shannon Diversity Index and global bacterial landscape indicate similar microbial communities on both unaffected and adjacent affected skin. The researchers noted that Psoriasis Area and Severity Index values decreased post-balneotherapy, which implied improvement of disease severity. No significant change in the Shannon Diversity Index was noticed at the end of the third week.
In addition the average taxonomic composition of skin microbial communities associated with unaffected and affected skin of psoriatic patients post-balneotherapy, shows that treatment with LRP-TSW significantly increased the level of Xanthomonas genus and, to a lesser extent, Corynebacterium genus, they reported. The Xanthomonas genus belongs to the main Xanthomonadaceae family found in LRP-TSW and also on healthy skin.
The researchers concluded that in psoriatic patients, a poor bacterial biodiversity was noticed and the bacterial communities were similar on unaffected and affected adjacent skin. Family analysis identified, for the first time, Xanthomonadaceae belonging to Proteobacteria phylum and known to be keratolytic, associated with the clinical improvement observed after a 3-week balneotherapy treatment. This data supports the interest of selenium-rich thermal spring water in the treatment of psoriasis vulgaris, they added.
Reference
1. Martin R, Henley JB, Sarrazin P, Seite S. Skin microbiome in patients with psoriasis before and after balneotherapy at the thermal care center of La Roche-Posay. J Drugs Dermatol. 2015;14(12):1400-1405.
A recent open label study,1 conducted between July and September 2012, examined microbial communities of patients with psoriasis vulgaris who were characterized prior and post a 3-week selenium-rich water balneotherapy treatment at the thermal care center in La Roche-Posay, France.
For the study, 54 patients diagnosed with moderate-to-severe forms of psoriasis vulgaris received balneotherapy, which consisted of high-pressure filiform showers, baths, facial, body spray treatments, and La Roche-Posay thermal spring water (LRP-TSW) consumption. Swabs were taken from affected and proximal unaffected skin and the 16S rRNA bacterial gene was used to analyze the composition of bacterial communities. Using the same 16S rRNA gene tool, the researchers described the LRP-TSW bacterial landscape.
After eliminating individuals lacking paired samples from both visits, 29 individuals were analyzed for their microbiome profile. Shannon Diversity Index and global bacterial landscape indicate similar microbial communities on both unaffected and adjacent affected skin. The researchers noted that Psoriasis Area and Severity Index values decreased post-balneotherapy, which implied improvement of disease severity. No significant change in the Shannon Diversity Index was noticed at the end of the third week.
In addition the average taxonomic composition of skin microbial communities associated with unaffected and affected skin of psoriatic patients post-balneotherapy, shows that treatment with LRP-TSW significantly increased the level of Xanthomonas genus and, to a lesser extent, Corynebacterium genus, they reported. The Xanthomonas genus belongs to the main Xanthomonadaceae family found in LRP-TSW and also on healthy skin.
The researchers concluded that in psoriatic patients, a poor bacterial biodiversity was noticed and the bacterial communities were similar on unaffected and affected adjacent skin. Family analysis identified, for the first time, Xanthomonadaceae belonging to Proteobacteria phylum and known to be keratolytic, associated with the clinical improvement observed after a 3-week balneotherapy treatment. This data supports the interest of selenium-rich thermal spring water in the treatment of psoriasis vulgaris, they added.
Reference
1. Martin R, Henley JB, Sarrazin P, Seite S. Skin microbiome in patients with psoriasis before and after balneotherapy at the thermal care center of La Roche-Posay. J Drugs Dermatol. 2015;14(12):1400-1405.
