Probiotic Mixture Reduces Clinical Severity and Intestinal Inflammation in Children With Atopic Dermatitis

Orally administering probiotics to children with atopic dermatitis (AD) can reduce clinical severity and intestinal inflammation.

“The aim of this study was to investigate the effects of a probiotic mixture on the clinical severity of AD, gut inflammatory markers and alterations in microbiome dysbiosis in children with AD,” wrote the study authors.

Researchers enrolled 25 participants in the study and administered a mixture of probiotic strains, which included Lactobacillus spp and Bifidobacterium spp for 4 weeks. The clinical efficacy was assessed using SCORing Atopic Dermatitis (SCORAD) index and transepidermal water loss(TEWL). To assess intestinal inflammation, fecal calprotectin levels were measured. The diversity and composition of the intestinal microbiome were studied with 16s rRNA sequencing.

After 4 weeks administration of the probiotic, the SCORAD, TEWL, and fecal calprotectin levels decreased. The α-diversity remained unchanged, but β-diversity increased after 4 weeks.

“The results of this study suggest that a probiotic mixture can alleviate AD by decreasing inflammation and modulating the gut microbiota in children with AD,” explained the study authors.

Reference
Yoon W, Park SH, Lee JS, et al. Probiotic mixture reduces gut inflammation and microbial dysbiosis in children with atopic dermatitis. Australas J Dermatol. Published online June 10, 2021. doi:10.1111/ajd.13644