Photodynamic Diagnosis Evaluation for Acne Inflammatory Skin Lesions

A preliminary study published in the Journal of Biophotonics has shed light on the potential of photodynamic diagnosis in evaluating acne inflammatory skin lesions. The study, which focused on the use of 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD), has showcased the potential of ALA-PDD as a valuable tool for evaluating acne inflammatory skin lesions. 

The researchers aimed to explore the fluorescence characteristics of these lesions and assess the feasibility of this technique. Additionally, the study delved into the advantages of predicting subclinical skin lesions.

Conducted using the OBSERV facial skin detector, the study involved 20 patients who underwent optical intra-tissue fiber irradiation photodynamic therapy. Over the course of 4 consecutive weeks, patients received treatment once a week, allowing researchers to collect data before and after treatment. The study specifically analyzed the correlation between ALA-PDD and white light patterns in recognizing inflammatory skin lesions.

The study's findings demonstrated that there was no significant difference between the 2 patterns in recognizing acne inflammatory skin lesions before and after treatment. Both ALA-PDD and white light patterns exhibited a strong correlation, with a correlation coefficient exceeding 0.90. This suggests that both methods are highly effective in recognizing various types of inflammatory skin lesions at different stages of treatment.

“ALA-PDD is a feasible method for evaluating acne inflammatory lesions, guiding treatment, and judging efficacy,” concluded the study authors.

Reference
Xu C, Yuan D, Cheng S, et al. A preliminary study on the evaluation of photodynamic diagnosis for acne inflammatory skin lesions. Published online Aug 29, 2023. J Biophotonics. doi:10.1002/jbio.202300160