Oxylipin Profiles Differ in Patients With Psoriasis vs Psoriatic Arthritis

Proinflammatory oxylipins were lower in both patients with psoriasis or with psoriatic arthritis (PsA) with higher skin scores, but arachidonic acid (AA)-derived oxylipins were increased in patients with PsA with enthesitis.

The authors compared the serum oxylipin profiles in patients with PsA and with psoriasis without inflammatory arthritis to examine the specific disease manifestations and identify new biomarkers. They recruited patients with PsA or with psoriasis from a rheumatology outpatient clinic and performed a thorough clinical examination, which included entheseal and joint involvement. Pain and global disease activity was evaluated on a visual analog scale, and they also calculated disease activity scores (Disease Activity Index for Psoriatic Arthritis [cDAPSA], Psoriasis Area and Severity Index [PASI]).

Patients included 20 with psoriasis and 19 with PsA. Higher PASI scores correlated with lower serum concentrations of proinflammatory oxylipins, most of which were AA-derived. However, several AA-derived oxylipins were increased in patients with PsA with enthesitis compared with those without. cDAPSA was not associated with oxylipin profiling.

“The AA-derived proinflammatory oxylipins were lower in both PsO and PsA patients with higher skin scores,” concluded the study authors. “Joint disease activity was not associated with the concentrations of oxylipins,” they added. “Yet, enthesitis was associated with an increase of AA-derived pro-inflammatory oxylipins in PsA patients.”

Reference
Coras R, Kavanaugh A, Kluzniak A, et al. Differences in oxylipin profile in psoriasis versus psoriatic arthritis. Arthritis Res Ther. 2021;23(1):200. doi:10.1186/s13075-021-02575-y