Neutrophil Components and Their Interactions With Immune Cells in Psoriasis

According to a study published in Skin Research and Technology, the function of neutrophil components and the interaction between neutrophils and immune cells play an essential role in the pathogenesis of psoriasis.

Researchers conducted a literature search using databases like PubMed and the China National Knowledge Infrastructure. They summarized the relevant findings to draw conclusions regarding the relationship between psoriasis and neutrophils.

The results revealed that neutrophils contribute to psoriasis by secreting important cytokines such as IL-23 and IL-17, which are known to be critical in psoriatic inflammation, as well as cytokines that attract TH17 cells. Moreover, activated keratinocytes (KCs) can attract and activate neutrophils, leading to the formation of neutrophil extracellular traps. Additionally, KCs may expose self-antigens, triggering strong autoimmune reactions. The granule proteins released by activated neutrophils can also activate IL-36, a protein that converts common psoriasis to a more severe form called generalized pustular psoriasis.

“The aim is to provide a theoretical basis for the exploration of targeted clinical treatments and fundamental research on the pathogenesis of psoriasis,” the authors concluded.

Reference
Wang Z, Shi D. Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis. Skin Res Technol. 2023;29(7):e13404. doi:10.1111/srt.13404