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Cytokine Profile Characterization in Patients With Psoriasis and Psoriatic Arthritis
According to a study published in Frontiers in Immunology, there is possibly a similar cytokine profile that could characterize naïve patients with psoriasis (PSO), psoriatic arthritis (PSA) with PSO, and PSA sine PSO, reinforcing the concept of a psoriatic disease continuum.
Researchers aimed to evaluate various biomolecules, including inflammatory cytokines, chemokines, cell adhesion, and cellular mediators, in different patient groups: those with PSO, those with PSA and PSO, and those with PSA but without PSO. The study also sought to stratify the results based on the presence of psoriatic nail involvement, extensive skin disease, and obesity, thus considering additional factors that might impact the disease.
The results of the study revealed patients with PSO showed significant increases in E-selectin and IL-8 compared with the other groups. In patients with PSA and PSO, elevated levels of ICAM-1 were observed. However, there were no further significant differences in pro-inflammatory and anti-inflammatory cytokines, inflammatory chemokines, and cell adhesion and cellular mediators between patients with PSO, PSA with PSO, and PSA sine PSO. The presence of psoriatic nail involvement was associated with increased levels of ICAM-1 and IP-10 compared with other patients. Patients with a higher Psoriasis Area and Severity Index (PASI ≥ 10) exhibited enhanced levels of IL-8, tumor necrosis factor, E-selectin, MIP-1α, and MIP-1β. Additionally, patients with a body mass index of 30 or higher had significantly higher levels of E-selectin.
“However, some differences may [also be] shown, underlying possible pathogenic differences and leading to the clinical heterogeneity of these patients,” the authors concluded.
Reference
Ruscitti P, Esposito M, Di Cola I, et al. Cytokine profile characterization of naïve patients with psoriasis and psoriatic arthritis: implications for a pathogenic disease continuum. Front Immunol. Published online July 13, 2023. doi:10.3389/fimmu.2023.1229516
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