Ceramide-Containing Skin Care in Acne Management

A recent review published in the Journal of Cosmetic Dermatology explores the often-overlooked relationship between acne and the skin's protective barrier function and the ways in which optimizing skin care regimens can play a pivotal role in acne prevention, treatment, and maintenance.

The study delves into the multifaceted world of acne and the intricate interplay between this skin condition and the skin's natural barrier. It emphasizes that acne is not just a surface-level concern, but a complex issue deeply intertwined with the skin's defense mechanisms. The review discusses the impact of acne on the epidermal barrier, which acts as the body's first line of protection against external factors.

The study's methodology involved a comprehensive review of previous research, including prescription and nonprescription treatments for pediatric acne and skin care regimens encompassing cleansers and moisturizers. The researchers analyzed the existing literature and their clinical experiences, resulting in 5 key statements.

One of the pivotal findings highlighted in the study is the direct involvement of the follicular epithelial barrier in the development of acne, particularly in the processes of comedogenesis and inflammation, where the integrity of the barrier can be compromised. Additionally, acne-affected skin exhibits distinct characteristics, such as enlarged sebaceous glands, elevated sebum production, increased filaggrin expression, and a reduction in stratum corneum lipids.

Educating both patients and health care providers on the central role of inflammation in acne and methods to reduce it is deemed essential for successful management. Skin irritation and dryness caused by acne itself and the treatments employed can lead to poor adherence to treatment plans. To address these challenges, the study recommends the inclusion of a well-structured skin care regimen as an integral part of the overall acne prevention, treatment, and maintenance strategy, with a focus on gentle cleansers and moisturizers containing ceramides.

“Epidermal barrier dysfunction contributes to acne exacerbation,” concluded the study authors. “Using the appropriate treatment and skin care helps to minimize irritation and inflammation, enhance treatment adherence, and improve patient outcomes.”

Reference
Schachner LA, Alexis AF, Andriessen A, et al. Insights into acne and the skin barrier: optimizing treatment regimens with ceramide-containing skincare. J Cosmet Dermatol. 2023;22(11):2902-2909. doi:10.1111/jocd.15946