Association Between Fatty Acids and Psoriasis Development

According to a study published in the Journal of Cosmetic Dermatology, n-3 fatty acids (FAs) could potentially lower the likelihood of developing psoriasis.

Researchers aimed to investigate the causal relationship between FA levels and psoriasis using a Mendelian randomization approach. Data were obtained from genome-wide association studies, and multiple types of FAs were analyzed. The results of the Mendelian analysis indicated a potential causal link between n-3 FA levels and a reduced risk of psoriasis, supported by a significant odds ratio and confidence interval (OR/95% CI: 0.998/(0.997, 0.999), P-value: 2.479 × 10^-4).

Additional analyses confirmed the consistency of these findings and ruled out horizontal pleiotropy, suggesting that the observed association was not influenced by other factors. However, no causal effects from other types of FAs on psoriasis were identified.

“We also need well-designed prospective studies and related large-scale, multicenter [randomized controlled trials] to confirm our findings,” the authors concluded.

Reference
Huang Y, Chen Z, Wu X, Chen C, Cai L. The effects of fatty acids on psoriasis: a two-sample mendelian randomization study. J Cosmet Dermatol. Published online April 28, 2024. doi:10.1111/jocd.16313