Research in the United States in the early 2000s determined the hyperhidrosis (excessive sweating) prevalence rate to be 2.7% of the population.1
A recent study by Doolittle and colleagues2 found that the prevalence of hyperhidrosis in the United States is much larger—at a minimum, it is about 5% of the total population, but the authors noted that 5% is a very conservative estimate. International studies have shown that the prevalence of both primary and secondary hyperhidrosis abroad is significantly higher: 14% in Japan, 16% in Germany, 18% in Shanghai, and 20% in Sweden.2
Research conducted by the International Hyperhidrosis Society found that just under half of people with hyperhidrosis in the United States have not talked about it with a provider because they do not understand that it is a medical condition or do not realize that treatment options are available. Furthermore, the research found that more than 50% of patients who see a provider about hyperhidrosis remain undiagnosed.3
Prescriptions medications are available for the treatment of hyperhidrosis. However, they can be expensive, irritating, painful, and inconvenient.
Over-the-counter (OTC) Carpe Lotion, from Clutch Inc, is a dermatologist recommended, FDA compliant, nonirritating antiperspirant lotion that goes on smooth, leaves no residue, prevents sweaty hands and feet, and is affordable. It is the only OTC solution available to treat palmar and plantar hyperhidrosis. It also has a soothing eucalyptus scent that fades quickly after application.
After washing and drying hands and/or feet, individuals should apply a pea-sized amount of Carpe Lotion 2 to 3 times a day (once before bed and 2 more times during the day) for at least 4 weeks. Based on other studies that have been conducted on antiperspirants, effects compound significantly with extended use; therefore, individuals may be able to use the lotion less frequently as time progresses.
In addition to the recommended regimen for Carpe Lotion, the lotion is also safe to apply on an as-needed basis. The convenience of Carpe Lotion allows individuals to bring it with them to a meeting, date, or interview, and apply it beforehand to ensure they have the sweat-free hands.
Studies conducted by independent labs have shown Carpe Lotion to be 100% nonirritating and effective. Further research is needed to show the efficacy of the product after extended use. Another study with Carpe Lotion’s active ingredient (aluminum sesquichlorohydrate) in a topical solution showed a 61% sweat reduction after 4 weeks of using the product several times a week.4 The Dermatologist Product Spotlight provides a summary of the efficacy and tolerability studies in individuals with hyperhidrosis treated with Carpe Lotion. (Due to funding restraints, the efficacy study could only be conducted over 3 days.)
References
1. Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004;51(2):241-248.
2. Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016;308(10):743-749.
3. Glaser DA, Ballard AM, Hunt NL, Pieretti LJ, Pariser DM. Prevalence of multifocal primary hyperhidrosis and symptom severity over time: results of a targeted survey. Dermatol Surg. 2016;42(12):1347-1353.
4. Innocenzi D, Ruggero A, Francesconi L, Lacarrubba F, Nardone B, Micali G. An open-label tolerability and efficacy study of an aluminum sesquichlorohydrate topical foam in axillary and palmar primary hyperhidrosis. Dermatol Ther. 2008;21(suppl 1):S27-S30.
Article continues on page 2
{{pagebreak}}
Studies: Efficacy and Tolerability of Carpe Lotion
Clutch Inc. Evaluation of hand antiperspirant efficacy. March 24, 2016. https://www.carpelotion.com/carpetestresults.pdf. Accessed January 24, 2017.5
Efficacy Study
Study Objective
To evaluate the effectiveness of Carpe Lotion.5
Method
After a baseline sweat collection, the participants were instructed to wash and thoroughly dry each hand. Treatment application was randomly assigned to either the left or right hand of each participant. While wearing a latex glove on the untreated control hand, the participants rubbed 1.0 mL of Carpe Lotion with moderate to hard force for 45 seconds, or until the hand was completely dry, focusing on the palm. Sweating was induced after a 15-minute waiting period in a constant temperature (100°F) and humidity (35% Rh) controlled test chamber. During the first 40 minutes of sweat stimulation, the participants wore cotton gloves on their hands. This was followed by 2 successive 20-minute collection periods. The cotton gloves were weighed at the beginning and end of the period. The study lasted for 3 days (1 application per day).5
Population
A total of 20 participants (10 men and 10 women) aged 21 to 60 years were included in the study. Inclusion criteria included participants in overall good health and free of any health problems including neurologic, dermatologic, or systemic disorder that would interfere with the study results; participants were not permitted use of any hand deodorant/antiperspirant materials and fragrant and medical products during the study period; and participants had to refrain from swimming and minimize other physical activities such as tennis and jogging during the study period. Exclusion criteria included participants with a diagnosis of hyperhidrosis or chronic skin allergies, taking medications that may mask or interfere with study outcomes, and a history of any form of skin cancer, melanoma, lupus, connective tissue disease, diabetes, or any disease that would increase the risk associated with study participation.5
Results
After 3 days of once-daily application, the participants experienced a mean sweat reduction of 24.52% (P<.05). Furthermore, 35% of participants experienced >30% sweat reduction after 3 days of single-day use. No adverse effects or unexpected reactions were observed in the study participants.5
Tolerability Study
Study Objective
To determine if Carpe Lotion induced primary or cumulative irritation and/or allergic contact sensization.5
Method
The upper back served as the treatment area. Approximately 0.2 mL of Carpe Lotion or an amount sufficient to cover the contact surface was applied to a 1×1 absorbent pad portion of a clear adhesive dressing 3 times per week for 3 weeks for a total of 9 applications. Approximately 2 weeks after the final application, a challenge patch was applied to an untreated area adjacent to the original patch site, following the same procedure for application. The patch was removed and the site scored on day 1 and day 3 post-application.5
Population
A total of 57 participants aged 18 to 65 years were evaluated for study inclusion; 54 participants completed the study. The 3 participants that did not complete the study discontinued for extraneous reasons. Inclusion criteria included the absence of any visible skin disease that might be confused with a skin reaction to the lotion, and no use of topical or systemic steroids and/or antihistamines for at least 7 days prior to study initiation. Participants who were under a doctor’s care or taking medication(s) that could influence the study outcome, females who were pregnant or nursing, and history of adverse reactions to cosmetics or other personal care products were excluded.5
Results
The findings indicated no potential for dermal irritation or allergic contact sensitization with Carpe Lotion. Among the 54 participants, no adverse events and no deviations were observed during the study period.5
Additional Resources
For more information on Carpe Lotion, please visit https://www.carpelotion.com. If you would like samples for your practice, please email david@carpelotion.com. The product is available for purchase from the Carpe Lotion website and Amazon.
Research in the United States in the early 2000s determined the hyperhidrosis (excessive sweating) prevalence rate to be 2.7% of the population.1
A recent study by Doolittle and colleagues2 found that the prevalence of hyperhidrosis in the United States is much larger—at a minimum, it is about 5% of the total population, but the authors noted that 5% is a very conservative estimate. International studies have shown that the prevalence of both primary and secondary hyperhidrosis abroad is significantly higher: 14% in Japan, 16% in Germany, 18% in Shanghai, and 20% in Sweden.2
Research conducted by the International Hyperhidrosis Society found that just under half of people with hyperhidrosis in the United States have not talked about it with a provider because they do not understand that it is a medical condition or do not realize that treatment options are available. Furthermore, the research found that more than 50% of patients who see a provider about hyperhidrosis remain undiagnosed.3
Prescriptions medications are available for the treatment of hyperhidrosis. However, they can be expensive, irritating, painful, and inconvenient.
Over-the-counter (OTC) Carpe Lotion, from Clutch Inc, is a dermatologist recommended, FDA compliant, nonirritating antiperspirant lotion that goes on smooth, leaves no residue, prevents sweaty hands and feet, and is affordable. It is the only OTC solution available to treat palmar and plantar hyperhidrosis. It also has a soothing eucalyptus scent that fades quickly after application.
After washing and drying hands and/or feet, individuals should apply a pea-sized amount of Carpe Lotion 2 to 3 times a day (once before bed and 2 more times during the day) for at least 4 weeks. Based on other studies that have been conducted on antiperspirants, effects compound significantly with extended use; therefore, individuals may be able to use the lotion less frequently as time progresses.
In addition to the recommended regimen for Carpe Lotion, the lotion is also safe to apply on an as-needed basis. The convenience of Carpe Lotion allows individuals to bring it with them to a meeting, date, or interview, and apply it beforehand to ensure they have the sweat-free hands.
Studies conducted by independent labs have shown Carpe Lotion to be 100% nonirritating and effective. Further research is needed to show the efficacy of the product after extended use. Another study with Carpe Lotion’s active ingredient (aluminum sesquichlorohydrate) in a topical solution showed a 61% sweat reduction after 4 weeks of using the product several times a week.4 The Dermatologist Product Spotlight provides a summary of the efficacy and tolerability studies in individuals with hyperhidrosis treated with Carpe Lotion. (Due to funding restraints, the efficacy study could only be conducted over 3 days.)
References
1. Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004;51(2):241-248.
2. Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016;308(10):743-749.
3. Glaser DA, Ballard AM, Hunt NL, Pieretti LJ, Pariser DM. Prevalence of multifocal primary hyperhidrosis and symptom severity over time: results of a targeted survey. Dermatol Surg. 2016;42(12):1347-1353.
4. Innocenzi D, Ruggero A, Francesconi L, Lacarrubba F, Nardone B, Micali G. An open-label tolerability and efficacy study of an aluminum sesquichlorohydrate topical foam in axillary and palmar primary hyperhidrosis. Dermatol Ther. 2008;21(suppl 1):S27-S30.
Article continues on page 2
{{pagebreak}}
Studies: Efficacy and Tolerability of Carpe Lotion
Clutch Inc. Evaluation of hand antiperspirant efficacy. March 24, 2016. https://www.carpelotion.com/carpetestresults.pdf. Accessed January 24, 2017.5
Efficacy Study
Study Objective
To evaluate the effectiveness of Carpe Lotion.5
Method
After a baseline sweat collection, the participants were instructed to wash and thoroughly dry each hand. Treatment application was randomly assigned to either the left or right hand of each participant. While wearing a latex glove on the untreated control hand, the participants rubbed 1.0 mL of Carpe Lotion with moderate to hard force for 45 seconds, or until the hand was completely dry, focusing on the palm. Sweating was induced after a 15-minute waiting period in a constant temperature (100°F) and humidity (35% Rh) controlled test chamber. During the first 40 minutes of sweat stimulation, the participants wore cotton gloves on their hands. This was followed by 2 successive 20-minute collection periods. The cotton gloves were weighed at the beginning and end of the period. The study lasted for 3 days (1 application per day).5
Population
A total of 20 participants (10 men and 10 women) aged 21 to 60 years were included in the study. Inclusion criteria included participants in overall good health and free of any health problems including neurologic, dermatologic, or systemic disorder that would interfere with the study results; participants were not permitted use of any hand deodorant/antiperspirant materials and fragrant and medical products during the study period; and participants had to refrain from swimming and minimize other physical activities such as tennis and jogging during the study period. Exclusion criteria included participants with a diagnosis of hyperhidrosis or chronic skin allergies, taking medications that may mask or interfere with study outcomes, and a history of any form of skin cancer, melanoma, lupus, connective tissue disease, diabetes, or any disease that would increase the risk associated with study participation.5
Results
After 3 days of once-daily application, the participants experienced a mean sweat reduction of 24.52% (P<.05). Furthermore, 35% of participants experienced >30% sweat reduction after 3 days of single-day use. No adverse effects or unexpected reactions were observed in the study participants.5
Tolerability Study
Study Objective
To determine if Carpe Lotion induced primary or cumulative irritation and/or allergic contact sensization.5
Method
The upper back served as the treatment area. Approximately 0.2 mL of Carpe Lotion or an amount sufficient to cover the contact surface was applied to a 1×1 absorbent pad portion of a clear adhesive dressing 3 times per week for 3 weeks for a total of 9 applications. Approximately 2 weeks after the final application, a challenge patch was applied to an untreated area adjacent to the original patch site, following the same procedure for application. The patch was removed and the site scored on day 1 and day 3 post-application.5
Population
A total of 57 participants aged 18 to 65 years were evaluated for study inclusion; 54 participants completed the study. The 3 participants that did not complete the study discontinued for extraneous reasons. Inclusion criteria included the absence of any visible skin disease that might be confused with a skin reaction to the lotion, and no use of topical or systemic steroids and/or antihistamines for at least 7 days prior to study initiation. Participants who were under a doctor’s care or taking medication(s) that could influence the study outcome, females who were pregnant or nursing, and history of adverse reactions to cosmetics or other personal care products were excluded.5
Results
The findings indicated no potential for dermal irritation or allergic contact sensitization with Carpe Lotion. Among the 54 participants, no adverse events and no deviations were observed during the study period.5
Additional Resources
For more information on Carpe Lotion, please visit https://www.carpelotion.com. If you would like samples for your practice, please email david@carpelotion.com. The product is available for purchase from the Carpe Lotion website and Amazon.
Research in the United States in the early 2000s determined the hyperhidrosis (excessive sweating) prevalence rate to be 2.7% of the population.1
A recent study by Doolittle and colleagues2 found that the prevalence of hyperhidrosis in the United States is much larger—at a minimum, it is about 5% of the total population, but the authors noted that 5% is a very conservative estimate. International studies have shown that the prevalence of both primary and secondary hyperhidrosis abroad is significantly higher: 14% in Japan, 16% in Germany, 18% in Shanghai, and 20% in Sweden.2
Research conducted by the International Hyperhidrosis Society found that just under half of people with hyperhidrosis in the United States have not talked about it with a provider because they do not understand that it is a medical condition or do not realize that treatment options are available. Furthermore, the research found that more than 50% of patients who see a provider about hyperhidrosis remain undiagnosed.3
Prescriptions medications are available for the treatment of hyperhidrosis. However, they can be expensive, irritating, painful, and inconvenient.
Over-the-counter (OTC) Carpe Lotion, from Clutch Inc, is a dermatologist recommended, FDA compliant, nonirritating antiperspirant lotion that goes on smooth, leaves no residue, prevents sweaty hands and feet, and is affordable. It is the only OTC solution available to treat palmar and plantar hyperhidrosis. It also has a soothing eucalyptus scent that fades quickly after application.
After washing and drying hands and/or feet, individuals should apply a pea-sized amount of Carpe Lotion 2 to 3 times a day (once before bed and 2 more times during the day) for at least 4 weeks. Based on other studies that have been conducted on antiperspirants, effects compound significantly with extended use; therefore, individuals may be able to use the lotion less frequently as time progresses.
In addition to the recommended regimen for Carpe Lotion, the lotion is also safe to apply on an as-needed basis. The convenience of Carpe Lotion allows individuals to bring it with them to a meeting, date, or interview, and apply it beforehand to ensure they have the sweat-free hands.
Studies conducted by independent labs have shown Carpe Lotion to be 100% nonirritating and effective. Further research is needed to show the efficacy of the product after extended use. Another study with Carpe Lotion’s active ingredient (aluminum sesquichlorohydrate) in a topical solution showed a 61% sweat reduction after 4 weeks of using the product several times a week.4 The Dermatologist Product Spotlight provides a summary of the efficacy and tolerability studies in individuals with hyperhidrosis treated with Carpe Lotion. (Due to funding restraints, the efficacy study could only be conducted over 3 days.)
References
1. Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004;51(2):241-248.
2. Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016;308(10):743-749.
3. Glaser DA, Ballard AM, Hunt NL, Pieretti LJ, Pariser DM. Prevalence of multifocal primary hyperhidrosis and symptom severity over time: results of a targeted survey. Dermatol Surg. 2016;42(12):1347-1353.
4. Innocenzi D, Ruggero A, Francesconi L, Lacarrubba F, Nardone B, Micali G. An open-label tolerability and efficacy study of an aluminum sesquichlorohydrate topical foam in axillary and palmar primary hyperhidrosis. Dermatol Ther. 2008;21(suppl 1):S27-S30.
Article continues on page 2
{{pagebreak}}
Studies: Efficacy and Tolerability of Carpe Lotion
Clutch Inc. Evaluation of hand antiperspirant efficacy. March 24, 2016. https://www.carpelotion.com/carpetestresults.pdf. Accessed January 24, 2017.5
Efficacy Study
Study Objective
To evaluate the effectiveness of Carpe Lotion.5
Method
After a baseline sweat collection, the participants were instructed to wash and thoroughly dry each hand. Treatment application was randomly assigned to either the left or right hand of each participant. While wearing a latex glove on the untreated control hand, the participants rubbed 1.0 mL of Carpe Lotion with moderate to hard force for 45 seconds, or until the hand was completely dry, focusing on the palm. Sweating was induced after a 15-minute waiting period in a constant temperature (100°F) and humidity (35% Rh) controlled test chamber. During the first 40 minutes of sweat stimulation, the participants wore cotton gloves on their hands. This was followed by 2 successive 20-minute collection periods. The cotton gloves were weighed at the beginning and end of the period. The study lasted for 3 days (1 application per day).5
Population
A total of 20 participants (10 men and 10 women) aged 21 to 60 years were included in the study. Inclusion criteria included participants in overall good health and free of any health problems including neurologic, dermatologic, or systemic disorder that would interfere with the study results; participants were not permitted use of any hand deodorant/antiperspirant materials and fragrant and medical products during the study period; and participants had to refrain from swimming and minimize other physical activities such as tennis and jogging during the study period. Exclusion criteria included participants with a diagnosis of hyperhidrosis or chronic skin allergies, taking medications that may mask or interfere with study outcomes, and a history of any form of skin cancer, melanoma, lupus, connective tissue disease, diabetes, or any disease that would increase the risk associated with study participation.5
Results
After 3 days of once-daily application, the participants experienced a mean sweat reduction of 24.52% (P<.05). Furthermore, 35% of participants experienced >30% sweat reduction after 3 days of single-day use. No adverse effects or unexpected reactions were observed in the study participants.5
Tolerability Study
Study Objective
To determine if Carpe Lotion induced primary or cumulative irritation and/or allergic contact sensization.5
Method
The upper back served as the treatment area. Approximately 0.2 mL of Carpe Lotion or an amount sufficient to cover the contact surface was applied to a 1×1 absorbent pad portion of a clear adhesive dressing 3 times per week for 3 weeks for a total of 9 applications. Approximately 2 weeks after the final application, a challenge patch was applied to an untreated area adjacent to the original patch site, following the same procedure for application. The patch was removed and the site scored on day 1 and day 3 post-application.5
Population
A total of 57 participants aged 18 to 65 years were evaluated for study inclusion; 54 participants completed the study. The 3 participants that did not complete the study discontinued for extraneous reasons. Inclusion criteria included the absence of any visible skin disease that might be confused with a skin reaction to the lotion, and no use of topical or systemic steroids and/or antihistamines for at least 7 days prior to study initiation. Participants who were under a doctor’s care or taking medication(s) that could influence the study outcome, females who were pregnant or nursing, and history of adverse reactions to cosmetics or other personal care products were excluded.5
Results
The findings indicated no potential for dermal irritation or allergic contact sensitization with Carpe Lotion. Among the 54 participants, no adverse events and no deviations were observed during the study period.5
Additional Resources
For more information on Carpe Lotion, please visit https://www.carpelotion.com. If you would like samples for your practice, please email david@carpelotion.com. The product is available for purchase from the Carpe Lotion website and Amazon.
