The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to www.galdermausa.com/Our-Commitment/Resident-Education.aspx
1. Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
b) Small intestine
c) Large intestine
d) Lung
e) Kidney
2. Which is a predisposing factor for this condition in a child with atopic dermatitis?
a) Late-onset atopic dermatitis
b) Low lgE levels
c) High lgE levels
d) Recent topical corticosteroid therapy
e) Recent systematic corticosteroid therapy
3. This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
b) PTCH1 (Gorlin syndrome)
c) COLA7A1 (dystrophic epidermolysis bullosa)
d) Lamin A (Hutchinson-Gilford progeria)
e) Ectodysplasin A (X-linked hypohidrotic ectodermal dysplasia)
4. Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C28Y and H63D) (porphyria cutanea tarda)
b) Kindlin-A (Kindler syndrome)
c) SLC39A4 (acrodermatitis enteropathica)
d) PHYH and PEX7 (Refsum disease)
e) FH (Leiomyomas, uterine fibroids, renal cancer)
To learn the answers, go to page 2
{{pagebreak}}
1. Sister Mary Joseph’s nodule
Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
Most lesions are adenocarcinomas; although the primary site is often not known, the most common identifiable site of origin is the stomach (20%).
Reference
Davar S, Hanna D. Sister Mary Joseph’s nodule. J Cutan Med Surg. 2012;16(3):201-204.
2. Eczema herpeticum
Which is a predisposing factor for this condition in a child with atopic dermatitis?
c) High lgE levels
Eczema herpeticum occurs most commonly in children with early-onset atopic dermatitis and in those with high lgE levels (which presumably correlate with severe or active disease). A new generation of drugs to combat herpes simplex virus infections (helicase-primase inhibitors) is the subject of intense research.
References
Luca NJ, Lara-Corrales I, Pope E. Eczema herpeticum in children: clinical features and factors predictive of hospitalization. J Pediatr. 2012;161(4):671-675.
Aronson PL, Yan AC, Mittal MK, Mohamad Z, Shah SS. Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. Pediatrics. 2011;128(6):1161-1167.
Mackool BT, Goverman J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 14-2012. A 43-year-old woman with a fever and a generalized rash. N Engl J Med. 2012;366(19):1825-1834.
Langan SM, Silcocks P, Williams HC. What causes flares of eczema in children? Br J Dermatol. 2009;161(3):640-646.
3. Cowden syndrome
This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
Thyroid and endometrial tumors are also seen. The trichilemmomas may be associated with human papillomavirus infection. (Note: COL7A1 is the type VII collagen gene).
References
Shen Z, Hoffman JD, Hao F, Pier E. More than just skin deep: faciocutaneous clues to genetic syndromes with malignancies. Oncologist. 2012;17(7):930-936.
Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009;59(2):73-98.
4. Porphyria cutanea tarda
Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C282Y and H63D) (porphyria cutanea tarda)
Porphyria cutanea tarda is most likely a multifactorial disease, with genetic factors, such as the hereditary HFE gene, and environmental factors, such as alcohol intake, smoking, hepatitis C infection and, in females, estrogen use, playing an important role in its expression. In patients with mutations in the hereditary HFE gene, phlebotomy appears to be superior to chloroquine for treatment.
References
Vieira FM, Nakhle MC, Abrantes-Lemos CP, Cancado EL, Reis VM. Precipitating factors of porphyria cutanea tarda in Brazil with emphasis on hemochromatosis gene (HFE) mutations. Study of 60 patients. An Bras Dermatol. 2013;88(4):530-540.
Castiella A, Zapata E, de Juan MD, et al. Significance of H63D homozygosity in a Basque population with hemochromatosis. J Gastroenterol Hepatol. 2010;25(7):1295-1298.
Cribier B, Chiaverini C, Dali-Youcef N, et al. Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. Dermatology. 2009;218(1):15-21.
Bruce Thiers, MD, FAAD, is a professor with the Department of Dermatology and Dermatologic Surgery at the Medical University of South Carolina in Charleston, SC.
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to www.galdermausa.com/Our-Commitment/Resident-Education.aspx
1. Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
b) Small intestine
c) Large intestine
d) Lung
e) Kidney
2. Which is a predisposing factor for this condition in a child with atopic dermatitis?
a) Late-onset atopic dermatitis
b) Low lgE levels
c) High lgE levels
d) Recent topical corticosteroid therapy
e) Recent systematic corticosteroid therapy
3. This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
b) PTCH1 (Gorlin syndrome)
c) COLA7A1 (dystrophic epidermolysis bullosa)
d) Lamin A (Hutchinson-Gilford progeria)
e) Ectodysplasin A (X-linked hypohidrotic ectodermal dysplasia)
4. Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C28Y and H63D) (porphyria cutanea tarda)
b) Kindlin-A (Kindler syndrome)
c) SLC39A4 (acrodermatitis enteropathica)
d) PHYH and PEX7 (Refsum disease)
e) FH (Leiomyomas, uterine fibroids, renal cancer)
1. Sister Mary Joseph’s nodule
Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
Most lesions are adenocarcinomas; although the primary site is often not known, the most common identifiable site of origin is the stomach (20%).
Reference
Davar S, Hanna D. Sister Mary Joseph’s nodule. J Cutan Med Surg. 2012;16(3):201-204.
2. Eczema herpeticum
Which is a predisposing factor for this condition in a child with atopic dermatitis?
c) High lgE levels
Eczema herpeticum occurs most commonly in children with early-onset atopic dermatitis and in those with high lgE levels (which presumably correlate with severe or active disease). A new generation of drugs to combat herpes simplex virus infections (helicase-primase inhibitors) is the subject of intense research.
References
Luca NJ, Lara-Corrales I, Pope E. Eczema herpeticum in children: clinical features and factors predictive of hospitalization. J Pediatr. 2012;161(4):671-675.
Aronson PL, Yan AC, Mittal MK, Mohamad Z, Shah SS. Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. Pediatrics. 2011;128(6):1161-1167.
Mackool BT, Goverman J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 14-2012. A 43-year-old woman with a fever and a generalized rash. N Engl J Med. 2012;366(19):1825-1834.
Langan SM, Silcocks P, Williams HC. What causes flares of eczema in children? Br J Dermatol. 2009;161(3):640-646.
3. Cowden syndrome
This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
Thyroid and endometrial tumors are also seen. The trichilemmomas may be associated with human papillomavirus infection. (Note: COL7A1 is the type VII collagen gene).
References
Shen Z, Hoffman JD, Hao F, Pier E. More than just skin deep: faciocutaneous clues to genetic syndromes with malignancies. Oncologist. 2012;17(7):930-936.
Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009;59(2):73-98.
4. Porphyria cutanea tarda
Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C282Y and H63D) (porphyria cutanea tarda)
Porphyria cutanea tarda is most likely a multifactorial disease, with genetic factors, such as the hereditary HFE gene, and environmental factors, such as alcohol intake, smoking, hepatitis C infection and, in females, estrogen use, playing an important role in its expression. In patients with mutations in the hereditary HFE gene, phlebotomy appears to be superior to chloroquine for treatment.
References
Vieira FM, Nakhle MC, Abrantes-Lemos CP, Cancado EL, Reis VM. Precipitating factors of porphyria cutanea tarda in Brazil with emphasis on hemochromatosis gene (HFE) mutations. Study of 60 patients. An Bras Dermatol. 2013;88(4):530-540.
Castiella A, Zapata E, de Juan MD, et al. Significance of H63D homozygosity in a Basque population with hemochromatosis. J Gastroenterol Hepatol. 2010;25(7):1295-1298.
Cribier B, Chiaverini C, Dali-Youcef N, et al. Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. Dermatology. 2009;218(1):15-21.
Bruce Thiers, MD, FAAD, is a professor with the Department of Dermatology and Dermatologic Surgery at the Medical University of South Carolina in Charleston, SC.
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to www.galdermausa.com/Our-Commitment/Resident-Education.aspx
1. Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
b) Small intestine
c) Large intestine
d) Lung
e) Kidney
2. Which is a predisposing factor for this condition in a child with atopic dermatitis?
a) Late-onset atopic dermatitis
b) Low lgE levels
c) High lgE levels
d) Recent topical corticosteroid therapy
e) Recent systematic corticosteroid therapy
3. This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
b) PTCH1 (Gorlin syndrome)
c) COLA7A1 (dystrophic epidermolysis bullosa)
d) Lamin A (Hutchinson-Gilford progeria)
e) Ectodysplasin A (X-linked hypohidrotic ectodermal dysplasia)
4. Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C28Y and H63D) (porphyria cutanea tarda)
b) Kindlin-A (Kindler syndrome)
c) SLC39A4 (acrodermatitis enteropathica)
d) PHYH and PEX7 (Refsum disease)
e) FH (Leiomyomas, uterine fibroids, renal cancer)
,
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to www.galdermausa.com/Our-Commitment/Resident-Education.aspx
1. Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
b) Small intestine
c) Large intestine
d) Lung
e) Kidney
2. Which is a predisposing factor for this condition in a child with atopic dermatitis?
a) Late-onset atopic dermatitis
b) Low lgE levels
c) High lgE levels
d) Recent topical corticosteroid therapy
e) Recent systematic corticosteroid therapy
3. This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
b) PTCH1 (Gorlin syndrome)
c) COLA7A1 (dystrophic epidermolysis bullosa)
d) Lamin A (Hutchinson-Gilford progeria)
e) Ectodysplasin A (X-linked hypohidrotic ectodermal dysplasia)
4. Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C28Y and H63D) (porphyria cutanea tarda)
b) Kindlin-A (Kindler syndrome)
c) SLC39A4 (acrodermatitis enteropathica)
d) PHYH and PEX7 (Refsum disease)
e) FH (Leiomyomas, uterine fibroids, renal cancer)
To learn the answers, go to page 2
{{pagebreak}}
1. Sister Mary Joseph’s nodule
Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
Most lesions are adenocarcinomas; although the primary site is often not known, the most common identifiable site of origin is the stomach (20%).
Reference
Davar S, Hanna D. Sister Mary Joseph’s nodule. J Cutan Med Surg. 2012;16(3):201-204.
2. Eczema herpeticum
Which is a predisposing factor for this condition in a child with atopic dermatitis?
c) High lgE levels
Eczema herpeticum occurs most commonly in children with early-onset atopic dermatitis and in those with high lgE levels (which presumably correlate with severe or active disease). A new generation of drugs to combat herpes simplex virus infections (helicase-primase inhibitors) is the subject of intense research.
References
Luca NJ, Lara-Corrales I, Pope E. Eczema herpeticum in children: clinical features and factors predictive of hospitalization. J Pediatr. 2012;161(4):671-675.
Aronson PL, Yan AC, Mittal MK, Mohamad Z, Shah SS. Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. Pediatrics. 2011;128(6):1161-1167.
Mackool BT, Goverman J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 14-2012. A 43-year-old woman with a fever and a generalized rash. N Engl J Med. 2012;366(19):1825-1834.
Langan SM, Silcocks P, Williams HC. What causes flares of eczema in children? Br J Dermatol. 2009;161(3):640-646.
3. Cowden syndrome
This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
Thyroid and endometrial tumors are also seen. The trichilemmomas may be associated with human papillomavirus infection. (Note: COL7A1 is the type VII collagen gene).
References
Shen Z, Hoffman JD, Hao F, Pier E. More than just skin deep: faciocutaneous clues to genetic syndromes with malignancies. Oncologist. 2012;17(7):930-936.
Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009;59(2):73-98.
4. Porphyria cutanea tarda
Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C282Y and H63D) (porphyria cutanea tarda)
Porphyria cutanea tarda is most likely a multifactorial disease, with genetic factors, such as the hereditary HFE gene, and environmental factors, such as alcohol intake, smoking, hepatitis C infection and, in females, estrogen use, playing an important role in its expression. In patients with mutations in the hereditary HFE gene, phlebotomy appears to be superior to chloroquine for treatment.
References
Vieira FM, Nakhle MC, Abrantes-Lemos CP, Cancado EL, Reis VM. Precipitating factors of porphyria cutanea tarda in Brazil with emphasis on hemochromatosis gene (HFE) mutations. Study of 60 patients. An Bras Dermatol. 2013;88(4):530-540.
Castiella A, Zapata E, de Juan MD, et al. Significance of H63D homozygosity in a Basque population with hemochromatosis. J Gastroenterol Hepatol. 2010;25(7):1295-1298.
Cribier B, Chiaverini C, Dali-Youcef N, et al. Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. Dermatology. 2009;218(1):15-21.
Bruce Thiers, MD, FAAD, is a professor with the Department of Dermatology and Dermatologic Surgery at the Medical University of South Carolina in Charleston, SC.
The contents of these questions are taken from the Galderma Pre-Board Webinar. The Pre-Board Webinar is now an online course. For details, go to www.galdermausa.com/Our-Commitment/Resident-Education.aspx
1. Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
b) Small intestine
c) Large intestine
d) Lung
e) Kidney
2. Which is a predisposing factor for this condition in a child with atopic dermatitis?
a) Late-onset atopic dermatitis
b) Low lgE levels
c) High lgE levels
d) Recent topical corticosteroid therapy
e) Recent systematic corticosteroid therapy
3. This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
b) PTCH1 (Gorlin syndrome)
c) COLA7A1 (dystrophic epidermolysis bullosa)
d) Lamin A (Hutchinson-Gilford progeria)
e) Ectodysplasin A (X-linked hypohidrotic ectodermal dysplasia)
4. Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C28Y and H63D) (porphyria cutanea tarda)
b) Kindlin-A (Kindler syndrome)
c) SLC39A4 (acrodermatitis enteropathica)
d) PHYH and PEX7 (Refsum disease)
e) FH (Leiomyomas, uterine fibroids, renal cancer)
1. Sister Mary Joseph’s nodule
Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
Most lesions are adenocarcinomas; although the primary site is often not known, the most common identifiable site of origin is the stomach (20%).
Reference
Davar S, Hanna D. Sister Mary Joseph’s nodule. J Cutan Med Surg. 2012;16(3):201-204.
2. Eczema herpeticum
Which is a predisposing factor for this condition in a child with atopic dermatitis?
c) High lgE levels
Eczema herpeticum occurs most commonly in children with early-onset atopic dermatitis and in those with high lgE levels (which presumably correlate with severe or active disease). A new generation of drugs to combat herpes simplex virus infections (helicase-primase inhibitors) is the subject of intense research.
References
Luca NJ, Lara-Corrales I, Pope E. Eczema herpeticum in children: clinical features and factors predictive of hospitalization. J Pediatr. 2012;161(4):671-675.
Aronson PL, Yan AC, Mittal MK, Mohamad Z, Shah SS. Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. Pediatrics. 2011;128(6):1161-1167.
Mackool BT, Goverman J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 14-2012. A 43-year-old woman with a fever and a generalized rash. N Engl J Med. 2012;366(19):1825-1834.
Langan SM, Silcocks P, Williams HC. What causes flares of eczema in children? Br J Dermatol. 2009;161(3):640-646.
3. Cowden syndrome
This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
Thyroid and endometrial tumors are also seen. The trichilemmomas may be associated with human papillomavirus infection. (Note: COL7A1 is the type VII collagen gene).
References
Shen Z, Hoffman JD, Hao F, Pier E. More than just skin deep: faciocutaneous clues to genetic syndromes with malignancies. Oncologist. 2012;17(7):930-936.
Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009;59(2):73-98.
4. Porphyria cutanea tarda
Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C282Y and H63D) (porphyria cutanea tarda)
Porphyria cutanea tarda is most likely a multifactorial disease, with genetic factors, such as the hereditary HFE gene, and environmental factors, such as alcohol intake, smoking, hepatitis C infection and, in females, estrogen use, playing an important role in its expression. In patients with mutations in the hereditary HFE gene, phlebotomy appears to be superior to chloroquine for treatment.
References
Vieira FM, Nakhle MC, Abrantes-Lemos CP, Cancado EL, Reis VM. Precipitating factors of porphyria cutanea tarda in Brazil with emphasis on hemochromatosis gene (HFE) mutations. Study of 60 patients. An Bras Dermatol. 2013;88(4):530-540.
Castiella A, Zapata E, de Juan MD, et al. Significance of H63D homozygosity in a Basque population with hemochromatosis. J Gastroenterol Hepatol. 2010;25(7):1295-1298.
Cribier B, Chiaverini C, Dali-Youcef N, et al. Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. Dermatology. 2009;218(1):15-21.
Bruce Thiers, MD, FAAD, is a professor with the Department of Dermatology and Dermatologic Surgery at the Medical University of South Carolina in Charleston, SC.
1. Sister Mary Joseph’s nodule
Biopsy shows a metastatic adenocarcinoma. The most common identifiable site of origin is the:
a) Stomach
Most lesions are adenocarcinomas; although the primary site is often not known, the most common identifiable site of origin is the stomach (20%).
Reference
Davar S, Hanna D. Sister Mary Joseph’s nodule. J Cutan Med Surg. 2012;16(3):201-204.
2. Eczema herpeticum
Which is a predisposing factor for this condition in a child with atopic dermatitis?
c) High lgE levels
Eczema herpeticum occurs most commonly in children with early-onset atopic dermatitis and in those with high lgE levels (which presumably correlate with severe or active disease). A new generation of drugs to combat herpes simplex virus infections (helicase-primase inhibitors) is the subject of intense research.
References
Luca NJ, Lara-Corrales I, Pope E. Eczema herpeticum in children: clinical features and factors predictive of hospitalization. J Pediatr. 2012;161(4):671-675.
Aronson PL, Yan AC, Mittal MK, Mohamad Z, Shah SS. Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. Pediatrics. 2011;128(6):1161-1167.
Mackool BT, Goverman J, Nazarian RM. Case records of the Massachusetts General Hospital. Case 14-2012. A 43-year-old woman with a fever and a generalized rash. N Engl J Med. 2012;366(19):1825-1834.
Langan SM, Silcocks P, Williams HC. What causes flares of eczema in children? Br J Dermatol. 2009;161(3):640-646.
3. Cowden syndrome
This autosomal dominant disorder is associated with an increased risk of breast cancer. The affected gene has been identified as:
a) PTEN (Cowden syndrome)
Thyroid and endometrial tumors are also seen. The trichilemmomas may be associated with human papillomavirus infection. (Note: COL7A1 is the type VII collagen gene).
References
Shen Z, Hoffman JD, Hao F, Pier E. More than just skin deep: faciocutaneous clues to genetic syndromes with malignancies. Oncologist. 2012;17(7):930-936.
Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009;59(2):73-98.
4. Porphyria cutanea tarda
Which gene mutation is most likely to be associated with this condition?
a) Hemochromatosis (HFE) gene (C282Y and H63D) (porphyria cutanea tarda)
Porphyria cutanea tarda is most likely a multifactorial disease, with genetic factors, such as the hereditary HFE gene, and environmental factors, such as alcohol intake, smoking, hepatitis C infection and, in females, estrogen use, playing an important role in its expression. In patients with mutations in the hereditary HFE gene, phlebotomy appears to be superior to chloroquine for treatment.
References
Vieira FM, Nakhle MC, Abrantes-Lemos CP, Cancado EL, Reis VM. Precipitating factors of porphyria cutanea tarda in Brazil with emphasis on hemochromatosis gene (HFE) mutations. Study of 60 patients. An Bras Dermatol. 2013;88(4):530-540.
Castiella A, Zapata E, de Juan MD, et al. Significance of H63D homozygosity in a Basque population with hemochromatosis. J Gastroenterol Hepatol. 2010;25(7):1295-1298.
Cribier B, Chiaverini C, Dali-Youcef N, et al. Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. Dermatology. 2009;218(1):15-21.
Bruce Thiers, MD, FAAD, is a professor with the Department of Dermatology and Dermatologic Surgery at the Medical University of South Carolina in Charleston, SC.
