CME Exam #111

1.) The chemoprevention agents of the future most likely to have the greatest utility for the primary prevention of skin cancers are: a.) Topical DNA-repair enzymes b.) Newer generation sunscreens/sunblocks c.) Beta-carotenes d.) Leukotriene inhibitors e.) Both a and b are correct 2.) Ultraviolet radiation (UVR) has a clearly defined role in skin carcinogenesis as a tumor: a.) Initiator b.) Promoter c.) Initiator and promoter d.) None of the above 3.) All of the following are common sense methods of primary and secondary skin cancer prevention EXCEPT: a.) Regular use of detergent UV-absorbers in clothing b.) Avoidance of UVR during midday hours c.) Daily sunscreen/sunblock use d.) Donning of white cotton fabrics e.) All of the above are good methods 4.) High risk patients in whom systemic chemoprevention strategies for skin cancer should be considered include all of the following EXCEPT those: a.) With history of prolonged PUVA use b.) On chronic immunosuppressive therapy c.) With family history of non-melanoma skin cancers d.) With inherited abnormalities in DNA-repair e.) With a history of multiple non-melanoma skin cancers 5.) Available data suggests that topical retinoids: a.) May decrease the number of Langerhans cells in the skin b.) Are not at all effective in the treatment of actinic keratoses c.) Should be used with caution in patients with on-going significant sun exposure d.) All of the above e.) None of the above 6.) One of the newer treatments for AKs, diclofenac sodium gel, is likely to exert its effect through: a.) Repair of cyclobutane pyrimidine dimers b.) Accumulation of protoporphyrin IX c.) Cox-2 inhibition d.) These agents are not at all effective in the treatment of actinic keratoses e.) None of the above 7.) Disadvantages for using systemic retinoids for chemoprevention include all of the following EXCEPT: a.) Mucocutaneous toxicity b.) Loss of efficacy upon discontinuation of therapy c.) Need for long term therapy d.) Long term bony complications e.) All of the above are disadvantages 8.) Ultraviolet B radiation exerts its carcinogenic effect on skin through: a.) Direct damage of DNA b.) Cutaneous immunosuppression c.) Creation of free oxygen radicals d.) A and B e.) All of the above 9.) The following antioxidant compound has been demonstrated to be effective in the chemoprevention of skin cancer in humans: a.) Beta-carotene b.) Alpha-Tocopherol c.) Green Tea d.) Black Tea e.) No antioxidant compound has been shown to be effective. 10.) The physical destruction of AKs: a.) Lowers the incidence of squamous cell carcinoma b.) Can destroy clonal proliferations of p53 mutated cells c.) Decreases risk for developing basal cell carcinoma d.) Can be used alone, without effective use of sunscreen, to control the proliferation of AK lesions. Instructions for Submitting Exams: Fill out the the postage-paid card that appears on the following page, or log on to www.skinandaging.com and respond electronically. Within 60 days, you will be advised that you have passed or failed the exam. A score of 70% or above will comprise a passing grade. A certificate will be awarded to participants who successfully complete the exam. Responses will be accepted up to 12 months from the publication date.