CME Exam #110

Choose the best response to each question listed below: 1) Mycosis Fungoides is usually a malignancy of a) Naïve CD8+ T cells b) Memory CD8+ T cells c) Naïve CD4+ T cells d) Memory CD4+ T cells 2) The classic presentation of mycosis fungoides includes all the following EXCEPT: a) Well-defined patches b) Lesions on the buttocks c) Pustules d) tumors 3) Topical therapies of mycosis fungoides include all the following EXCEPT: a) Corticosteroids b) BCNU c) Nitrogen mustard d) Benzoyl Peroxide 4) Which of the following pan T cell marker is most commonly deficient on mycosis fungoides cells? a) CD2 b) CD4 c) CD5 d) CD7 5) To which class of agents does denileukin diftitox (DAB-IL2) belong? a) Macrolide antibiotics b) Fusion proteins c) Alkylating agents d) Retinoids 6) Which of the following statements about mycosis fungoides is most accurate? a) In early stages, MF is an indolent disease b) MF is aggressive in older patients c) MF is aggressive in all patients d) MF is always an indolent disease 7) Which statement most accurately describes mycosis fungoides? a) Mycosis fungoides is a monoclonal expansion of lymphocytes b) Mycosis fungoides is an oligoclonal expansion of lymphocytes c) Mycosis fungoides is a polyclonal expansion of lymphocytes d) Mycosis fungoides is a recalcitrant fungal disease 8) Which of the following is LEAST useful in diagnosing mycosis fungoides histologically? a) Dense dermal infiltrate b) Epidermal lymphocytes with convoluted nuclei c) Epidermal lymphocytes in clusters d) Dermal lymphocytes abutting the epidermis 9) Which of the following cytokines have NOT been used therapeutically for mycosis fungoides? a) Interferon alpha b) Interleukin 2 c) Interleukin 12 d Transforming growth factor beta 10) Which group of Americans has the highest rate of mycosis fungoides? a) African Americans b) Asian Americans c) European Americans d) There is no racial predilection