CME Exam # 113 — December 2002

Choose the best response to each question listed below: 1. Inflammatory cells in psoriasis: a) are mixed T and B cells b) are cytotoxic T cells c) exhibit a TH1 response d) exhibit a TH2 response 2. In the treatment of psoriasis, which of the following statements is true? a) Alefacept binds CD2 (LFA3 ligand) on activated T cells. b) Efalizumab blocks receptors on antigen-presenting cells necessary for T-cell activation. c) Etanercept and infliximab are anti-TNF-alpha agents. d) All of the above statements are true. 3. Which of the following is true about pimecrolimus? a) It targets calcineurin and calcium-dependent phosphatase. b) It’s used mainly in the treatment of severe atopic dermatitis. c) It suppresses the activation of type I but not type II T cells. d) It needs to be used as an adjunctive therapy. 4. In the treatment of actinic keratosis, which of the following is false? a) Aminolevulinic acid (ALA) locally increases INF-alpha and IL-6 and IL-8 b) Hyluronan is an active agent and diclofenac acts as its vehicle. c) ALA is converted into protoporphyrin IX, a photosensitizer upon illumination d) Imiquimod locally inhibits cytokine production, subsequently exerting an antiviral effect. 5. When talking about mycosis fungoides (MF) treatment, which of the following statements is true? a) Treatment with bexarotene gel is indicated for tumor-stage MF. b) Bexarotene gel is approved for the treatment of stage IA through IIA MF. c) Total remission is seen in more than 90% of treated patients treated with bexarotene gel. d) Significantly elevated blood levels of bexarotene gel are achieved in treated patients. 6. The following is true about vitiligo: a) Calcipotriene monotherapy might be of value. b) Considerable improvement is seen with calcipotriene and PUVA combination therapy. c) Total UVA dose can be lowered by using the combination calcipotriene/phototherapy. d) All of the above are true. 7.Which of the following is true about tazarotene? a) It’s a retinoid X receptor. b) Tazarotene is approved to treat acne in its lower 0.05% formulation. c) It’s a pregnancy category C drug. d) Tazarotene is a selective synthetic retinoid that binds RAR beta and RAR gamma receptors. 8. Which of the following is true about acne treatments? a) Tazarotene was shown to be more effective than adapalene 0.1%. b) Tazarotene was shown to be more effective than tretinoin 0.1%. c) Blue light and mid infrared lasers are treatment options. d) All of the above are true. 9. When discussing warts, which of the following is true? a) Dinitrochlorobenzene, diphencyprone, and squaric acid are toxic to HPV-infected keratinocytes. b) Imiquimod is a sensitizer in the treatment of verruca vulgaris. c) Candida antigens are used to treat warts in immuno-deficient patients. d) Clearing of warts occurred in 74% of immune patients injected with candida and mumps antisera. 10. Which of the following is true about Botox? a) It blocks calcium channel pumps on muscle cells. b) Botox blocks the Na/K pump c) It blocks acetylcholine release from presynaptic nerve terminals. d) It’s not effective in the treatment of glabellar lines.