Insights on Pulsed Acoustic Cellular Expression

Hi, I'm Dr. Windy Cole. I am the director of Wound Care Research at Kent State University College of Pediatric Medicine. And I'm here to talk a little bit about my presentation, Energy First Harnessing the Power of Pulsed Acoustic Cellular Expression.

PACE therapy, otherwise known as pulsed acoustic cellular expression is the use of biphasic high energy acoustic shockwave, very similar to lithotripsy or ESWT extracorporal shockwave therapy you might be familiar with in the field of medicine.

And what these high energy acoustic shockwaves do is they apply tensile and compressive stresses to cells that help to up-regulate the expression of angiogenic growth factors. And that helps with angiogenesis and neovascularization, which is really important for wound healing, because it can increase blood flow to wounded tissues. It helps increase oxygenation to wounded tissues as well. And it allows for those very important active cellular processes to occur, so the induction of fibroblasts into the wound to help with collagen matrix formation. So it really does flip on a light switch and jumpstart wound healing.

PACE therapy is approved for use in diabetic foot ulcers currently. I think there is application in other types of wound, but currently, it's FDA cleared for use in diabetic foot ulcers.

I was an early adopter of the technology. I've used it in my research clinic and now also in my outpatient wound care center. And I am speaking about a recently published 15 patient case series, which we followed these patients through the therapy with, with the PACE technology to see the wound area reduction, and then also track increase in oxygenation and the wounded tissues.

It's very easy to utilize. It really does fit in into the flow of an office or an outpatient clinical setting. Really, it only adds maybe three minutes to a wound care visit. Patients tolerate it very well. And it seems to be a very effective therapy again to help to jump start these chronic wounds and move them into that healing trajectory.