A Case Series to Track the Use of a High Osmolarity Biofilm Disrupting Surfactant to Decrease Bioburden and Inflammation in Non-Healing Chronic Wounds of the Lower Extremity

A biofilm is a very complex structured environment formed by a mix of different microorganisms that adhere to wound surfaces. Biofilm has become a difficult and challenging health problem. This structured formation is a resistance mechanism used by bacteria against antibiotics and the patient’s own immune system. The presence of bacteria as structured biofilms in chronic wounds, especially in the diabetic patients, is thought to prevent wound healing and resolution. Development and use of biofilm disrupting technology is crucial as adjunctive treatment options for chronic diabetic foot ulcerations.

OBJECTIVE:

This is a case report series of the authors’ experience with the use of a biofilm disrupting topical gel on chronic lower extremity wounds that have not responded to standard therapy.